Perturb-Multi generates rich, multimodal data that can generate fundamentally new insights about the impact of genetic perturbations on tissue function. Check it out!

We used lentiviral delivery of sgRNAs to create genetic mosaic organs, separately knocking out hundreds of genes in the liver of a single mouse.

Perturb-Multi is a platform for pooled genetic screens in intact mammalian tissue with spatial (MERFISH and multiplexed immunofluorescence) and scRNA-seq-based phenotyping.