So excited to be funded by @erc.europa.eu to work with this extraordinarily talented group of scientists on the GeneMotors project - unravelling how SMC motors work, how they are regulated and how they regulate gene expression.

@ceesdekker.bsky.social @uoe-igc.bsky.social

Honoured to be in Birmingham to mark Bryan Turner’s retirement- a gentleman and giant of epigenetics.

Well, we survived our ERC Synergy interview. So exciting working with this great GeneMotors team of SMC experts @ceesdekker.bsky.social Benjamin Rowland, Leonid Mirny. Here's hoping we can continue working together for the next 6 years.

Working class women makes inadvertent mistake and resigns.
Posh bloke uses devious means to avoid paying income tax and stamp duty... and doesn't resign.

www.theguardian.com/politics/202...

GWAS to mechanism: when non-coding is coding. Beautiful insightful science from @gweykopf.bsky.social @simonbiddie.bsky.social Joe Marsh and many colleagues. @uoe-igc.bsky.social @cmvm-edinburghuni.bsky.social www.biorxiv.org/content/10.1...

Great to see this published @genesdev.bsky.social. Evidence that enhancers can activate a bystander gene in an adjacent TAD, and that cohesin facilitates this. @uoe-igc.bsky.social.
pubmed.ncbi.nlm.nih.gov/40436628/

ZC3HC1 and TPR is not required for TPR localisation at the nuclear pore basket, and the two have different functions. wellcomeopenresearch.org/articles/10-...

Unpicking non-coding genetic variation: Structure-guided modelling holds promise for evaluating how single nucleotide variants affect transcription factor binding. www.biorxiv.org/content/10.1.... @uoe-igc.bsky.social

Feels like a small act of defiance, or at least group therapy. Packed audience in Edinburgh 2nite.

Welcome to Bluesky Edinburgh Epigenetics
@edinepigenetics.bsky.social

Our new paper showing how loss of the nuclear pore protein TPR leads to activation of an inflammatory gene expression programme in senescence is now published in eLife: bit.ly/4h1VcFi
@wbickmor.bsky.social @uoe-igc.bsky.social
@elife.bsky.social

View at night pretty special too

Stunning winter morning in Edinburgh. Can you beat this for a view from your office?

Interested in difficult to access parts of genetics, cellular & structural biology? Join us in Edinburgh 2-4th April 2025 for "Hidden Cell, Dark Genome"
Regulation in the dark genome
Uncharted proteins, RNA complexity
Atomic structures at cellular scale
Cell diversity
www.ed.ac.uk/c/hidden-cel...

One enhancer can activate two endogenous genes simultaneously and across a TAD Boundary. Check out our new preprint.
www.biorxiv.org/content/10.1...