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walrusz.fedi.walrusz.hu.ap.brid.gy
Walrusz
@walrusz.fedi.walrusz.hu.ap.brid.gy
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internetrozmár

:linux: Linux – 🖥️:fedora: / 💻️:opensuse: / ☁️:nixos:

Speaking: 🇭🇺 🇬🇧
Learning: 🇮🇹 🇯🇵

[bridged from https://fedi.walrusz.hu/@walrusz on the fediverse by https://fed.brid.gy/ ]
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Reposted by Walrusz
c-9.mstdn.ca.ap.brid.gy
Umm, this is big COVID vaccine news. Nobody tell RFK Jr.

Original thread at link below.

THIS IS HUGE! Researchers at Stanford University have developed a dual-antibody treatment that remains effective against ALL SARS-CoV-2 variants by targeting a less-mutable […]

[Original post on mstdn.ca]
Abstract The ongoing emergence of severe acute respiratory syndrome coronavirus (SARS-CoV-2) variants of concern that reduce the effectiveness of antibody therapeutics necessitates development of next-generation antibody modalities that are resilient to viral evolution. Here, we characterized amino-terminal domain (NTD) - and receptor binding domain (RBD)-specific monoclonal antibodies previously isolated from COVID-19 convalescent donors for their activity against emergent SARS-CoV-2 VOCs. Among these, NTD-specific antibody C1596 displayed the greatest breadth of binding to VOCs, with cryo-electron microscopy structural analysis revealing recognition of a distinct NTD epitope outside of the site i antigenic supersite. Given C1596's favorable binding profile, we designed a series of bispecific antibodies (bsAbs), termed CoV2-biRNs, that featured both NTD & RBD specificities. Two of the C1596-inclusive bsAbs, CoV2-biRN5 and CoV2-biRN7, retained potent in vitro neutralization activity against all Omicron variants tested, including XBB.1.5, BA.2.86, and JN.1, contrasting the diminished potency of parental antibodies delivered as monotherapies or as a cocktail. Furthermore, prophylactic delivery of CoV2-biRN5 reduced viral load within the lungs of K18-hACE2 mice after challenge with SARS-CoV-2 XBB.1.5. In conclusion, NTD-RBD bsAbs offer promising potential for the design of resilient, next-generation antibody therapeutics against SARS-CoV-2 VOCs. Diagram showing NTD Antibody + RBD Antibody leading to a combination labeled CoV2-biRN More realistic diagram rather than the previous geometric one, showing NTD and RBD before and after the new approach has attached itself.
March 10, 2025 at 1:00 AM
walrusz.fedi.walrusz.hu.ap.brid.gy
👀 ❓
February 25, 2025 at 3:45 PM
Reposted by Walrusz
futurebird.sauropods.win.ap.brid.gy
Someone on tumblr fixed this wasp meme that was going around for a bit.

(tumblr: https://www.tumblr.com/shailion/751682449465049088/fixed-a-wasp-meme )
A meme about wasps that was poorly edited to be wasp positive. In the top right corner there is a picture of a black, yellow, and orange cicada killer wasp with text next to it that says this one is a cicada killer who are very unlikely to sting humans From the top left there is text going down the image that says: Do you see this? Do you know what this is? this is a wasp. It's mission in nature is to live. It pollinates things. Some make honey It is in the order hymenoptera along with bees and ants. It is a [large blank space] wasp [smile emoticon] you cannot battle the wasp. most wasps are solitary. Paper wasps are eusocial meaning they work together to defend the nest and are calm unless they or the nest are threatened. When you see a wasp, do you know what you do? You chill out you move slowly you hope the wasp has a nice day And wait for the wasp to finish its business and move on
January 30, 2025 at 10:57 AM
Reposted by Walrusz
jaredkostrzewa.bsky.social
In northern Japan and the forests of China you can see these flowers that look normal but when they come into contact with water their petals become transparent.
Its name is skeleton flower or glass flower, its scientific name is Diphylleia grayi. #nature #natura #flowers #flower #photography #wild
January 15, 2025 at 9:23 AM
walrusz.fedi.walrusz.hu.ap.brid.gy
October 10, 2024 at 2:32 PM
walrusz.fedi.walrusz.hu.ap.brid.gy
Néha elgondolkodom ezen
August 29, 2024 at 4:17 PM
Reposted by Walrusz
futurebird.sauropods.win.ap.brid.gy
Comic by cupcakesnake via tumblr: https://www.tumblr.com/futurebird/756800902531268608/image-description-four-panel-comic-panel-one?source=share
Image Description: Four panel comic. Panel one: A carefully drawn realistic, with fangs, but still kind of cute centipede says "I eat cockroaches" Panel two: A person leans over the table where the little centipede is resting. They say "For us?" the centipede responds "No, just hungry." Panel three: The person looks angry and says "Can't you at least look a bit more pleasing?" Panel four: We move closer in to see the centipede respond. We can see their big black eyes, antennae, sharp fangs, little mouth and many legs. It says "I literally don't care. I just wanna live." Comic is signed "Snake"
July 23, 2024 at 1:34 PM
walrusz.fedi.walrusz.hu.ap.brid.gy
Ha Tarzan a dzsungelben nőtt fel és megérkezik a civilizációba, a papírjain mit fog írni az "anyja leánykori neve" mezőbe? :blobfoxthonking:
July 7, 2024 at 1:32 PM