voidcreature
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voidcreature.at.app.wafrn.net
voidcreature
@voidcreature.at.app.wafrn.net
5 followers 11 following 140 posts
I'm some sort of creature who is also somehow good at computershe/they/itI do art occasionallymy identity is a mess so I don't typically use labels, but I[...]

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Reposted by voidcreature
cpsc.gov
As you can see from the graphic, there is a real danger of a wormhole sucking your feet towards the space heater and causing a fire.
December 29, 2025 at 3:54 PM
Reposted by voidcreature
sailorrooscout.bsky.social
In preclinical models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer’s biomarkers (in HUMAN models as well).
• case.edu/news/new-stu...

The study has been published in Cell. YES, it is PEER-REVIEWED.
• www.cell.com/cell-reports...

🧪🧵⬇️
Highlights •Severity of Alzheimer's disease (AD) correlates with NAD+ homeostasis dysregulation •Preserving brain NAD+ homeostasis prevents AD in mice • Restoring brain NAD+ homeostasis reverses advanced AD in mice • Multiomics across human and mouse AD brain identifies nodes for human AD reversal Summary Alzheimer's has long been considered irreversible, but new research challenges that assumption. Scientists discovered that severe drops in the brain's energy supply help drive the disease-and restoring that balance can reverse damage, even in advanced cases. In mouse models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer's biomarkers. The results offer fresh hope that recovery may be possible. Abstract Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217. P7C3-A20 also reverses advanced disease in tau-driven PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care. Graphical Abstract (CREDIT: Cell Reports Medicine)
December 28, 2025 at 5:03 PM
voidcreature.at.app.wafrn.net
gah I love these so much, so creatureful, so silly, lobve hgbrvbrrbr
these images make me happy
December 25, 2025 at 3:44 AM
voidcreature.at.app.wafrn.net
*checks notifications*
*gets mauled to death*
December 23, 2025 at 3:52 AM
Reposted by voidcreature
maxadisasta.bsky.social
Game is *brutal* my GOD, would recommend giving it a try though.

Vibes-wise made me feel like I was playing mouth-washing again when I was trying to fix up expie after breaking and dislocating the same leg twice.. It gets DARK.
December 22, 2025 at 2:52 PM
Reposted by voidcreature
sapphiringore.bsky.social
2-hour sketch cmm for Aerwhisp! <3
December 21, 2025 at 9:47 PM
voidcreature.at.app.wafrn.net
got my friends to unfuck it 👍
December 17, 2025 at 6:59 PM