Victor Javier
@vjsanchez.bsky.social
Associate Professor at UFV. Head of the Molecular Oncology Group. Hospital 12 de Octubre, Pancreatic Cancer, 🧪🔬Epigenetics, Therapeutic targets, Python, Machine Learning, Statistics and Bioinformatics. 🖥️🧬
Pinned
Victor Javier
@vjsanchez.bsky.social
· Oct 21
"Teaching is an antidote to failure" Paul Nurse, Nobel Laureate
YouTube video by NobelPrizeII
www.youtube.com
That’s why I combine teaching with research. Wise words by Paul Nurse, Nobel Laureate. “Teaching is an antidote to failure”
www.youtube.com/watch?v=0GoF...
www.youtube.com/watch?v=0GoF...
Reposted by Victor Javier
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
Contrastive virtual staining enhances deep learning‐based PDAC subtyping from H&E‐stained tissue cores pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/... #PancreaticCancer
Contrastive virtual staining enhances deep learning‐based PDAC subtyping from H&E‐stained tissue cores
Pancreatic ductal adenocarcinoma (PDAC) subtyping typically relies on immunohistochemistry (IHC) staining for critical markers like HNF1A and KRT81, a labor-intensive manual staining process that int...
pathsocjournals.onlinelibrary.wiley.com
November 6, 2025 at 10:42 AM
Contrastive virtual staining enhances deep learning‐based PDAC subtyping from H&E‐stained tissue cores pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/... #PancreaticCancer
Elevated levels of cleaved soluble forms of urokinase-type Plasminogen Activator Receptor are associated with poor survival in advanced #PancreaticCancer. www.sciencedirect.com/science/arti...
Elevated levels of cleaved soluble forms of urokinase-type Plasminogen Activator Receptor are associated with poor survival in advanced pancreatic cancer.
Different forms of urokinase plasminogen activator receptor (uPAR) in tissues and plasma are associated with poor prognosis in several types of cancer…
www.sciencedirect.com
November 6, 2025 at 10:40 AM
Elevated levels of cleaved soluble forms of urokinase-type Plasminogen Activator Receptor are associated with poor survival in advanced #PancreaticCancer. www.sciencedirect.com/science/arti...
TMEtyper: A computational method for tumor microenvironment subtyping with applications in immunotherapy www.sciencedirect.com/science/arti...
TMEtyper: A computational method for tumor microenvironment subtyping with applications in immunotherapy
The heterogeneity of the tumor microenvironment (TME) is a critical determinant of outcomes in immune checkpoint blockade (ICB) therapy. However, robu…
www.sciencedirect.com
November 6, 2025 at 10:38 AM
TMEtyper: A computational method for tumor microenvironment subtyping with applications in immunotherapy www.sciencedirect.com/science/arti...
Therapeutic Eradication of Cancer-associated Fibroblasts Inhibits in vivo progression of #PancreaticCancer www.biorxiv.org/content/10.1...
Therapeutic Eradication of Cancer-associated Fibroblasts Inhibits in vivo progression of Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease with an unmet medical need. therapeutic elimination of cancer associated fibroblasts (CAFs), key drivers of tumor aggressiveness, has b...
www.biorxiv.org
November 6, 2025 at 10:26 AM
Therapeutic Eradication of Cancer-associated Fibroblasts Inhibits in vivo progression of #PancreaticCancer www.biorxiv.org/content/10.1...
Just finished differential expression analysis! What tools do you recommend for studying miRNA-regulated pathways? So far, folks suggest TargetScan, miRDB, DIANA-microT, and miRPathDB for target prediction + KEGG/GO for pathway enrichment. Any hidden gems? #miRNA #Bioinformatics #ResearchTips 🧬🖥️
November 5, 2025 at 8:31 PM
Just finished differential expression analysis! What tools do you recommend for studying miRNA-regulated pathways? So far, folks suggest TargetScan, miRDB, DIANA-microT, and miRPathDB for target prediction + KEGG/GO for pathway enrichment. Any hidden gems? #miRNA #Bioinformatics #ResearchTips 🧬🖥️
Association of tumor associated collagen signature with lymph node metastasis in pancreatic ductal adenocarcinoma #PancreaticCancer aiche.onlinelibrary.wiley.com/doi/10.1002/...
Association of tumor associated collagen signature with lymph node metastasis in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and fatal cancer with significant metastatic potential. Lymph node status is crucial for determining treatment options and predicting pr...
aiche.onlinelibrary.wiley.com
November 5, 2025 at 8:10 AM
Association of tumor associated collagen signature with lymph node metastasis in pancreatic ductal adenocarcinoma #PancreaticCancer aiche.onlinelibrary.wiley.com/doi/10.1002/...
DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors #PancreaticCancer www.sciencedirect.com/science/arti...
DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors
Mutations in KRAS drive 88% of pancreatic ductal adenocarcinomas (PDAC) and up to 40% of low-grade serous ovarian cancers (LGSOC), making KRAS a long-…
www.sciencedirect.com
November 5, 2025 at 8:08 AM
DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors #PancreaticCancer www.sciencedirect.com/science/arti...
m6A demethylase FTO drives pancreatic ductal adenocarcinoma tumorigenesis and metastasis through remodeling PFKM mediated glycolysis #PancreaticCancer www.nature.com/articles/s41...
m6A demethylase FTO drives pancreatic ductal adenocarcinoma tumorigenesis and metastasis through remodeling PFKM mediated glycolysis - Cell Death & Disease
Cell Death & Disease - m6A demethylase FTO drives pancreatic ductal adenocarcinoma tumorigenesis and metastasis through remodeling PFKM mediated glycolysis
www.nature.com
November 5, 2025 at 7:58 AM
m6A demethylase FTO drives pancreatic ductal adenocarcinoma tumorigenesis and metastasis through remodeling PFKM mediated glycolysis #PancreaticCancer www.nature.com/articles/s41...
A machine learning-based method to optimize the immunogenicity of human leukocyte antigen class I-restricted neoantigens academic.oup.com/bib/article/...
A machine learning-based method to optimize the immunogenicity of human leukocyte antigen class I-restricted neoantigens
Abstract. Neoantigens, arising from somatic mutations, have the potential to induce immune responses against tumor cells. As natural neoantigens that drive
academic.oup.com
November 5, 2025 at 7:56 AM
A machine learning-based method to optimize the immunogenicity of human leukocyte antigen class I-restricted neoantigens academic.oup.com/bib/article/...
@zotero.org is not running in some computers after @fedora.fosstodon.org.ap.brid.gy update. Are you planning an update? Thanks 🙏
November 2, 2025 at 1:18 PM
@zotero.org is not running in some computers after @fedora.fosstodon.org.ap.brid.gy update. Are you planning an update? Thanks 🙏
Reposted by Victor Javier
Lo de que la gente esté entendiendo mal los dislikes que van a implementar qué es? Los dislikes no te van a salir como los likes, son privados y se usarán únicamente para entrenar los feeds con algoritmo como Discover. Por favor, leed un poco, solo un poco.
Progress Update: Building Healthier Social Media - Bluesky
Over the next few months, we’ll be iterating on the systems that make Bluesky a better place for healthy conversations. Some experiments will stick, others will evolve, and we’ll share what we learn a...
bsky.social
November 2, 2025 at 12:14 PM
Lo de que la gente esté entendiendo mal los dislikes que van a implementar qué es? Los dislikes no te van a salir como los likes, son privados y se usarán únicamente para entrenar los feeds con algoritmo como Discover. Por favor, leed un poco, solo un poco.
Reposted by Victor Javier
«Si tienes un móvil Android, tienes que dejar de navegar con Chrome» loquesomos.es/si-tienes-un...
"Si tienes un móvil Android, tienes que dejar de navegar con Chrome" - LoQueSomos
Si tienes un móvil Android, tienes que dejar de navegar con Chrome, privacidad, robo de datos, nevgadores, Tor, Firefox
loquesomos.es
November 2, 2025 at 7:12 AM
«Si tienes un móvil Android, tienes que dejar de navegar con Chrome» loquesomos.es/si-tienes-un...
DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in #PancreaticCancer advanced.onlinelibrary.wiley.com/doi/10.1002/...
DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and d...
advanced.onlinelibrary.wiley.com
October 31, 2025 at 8:48 AM
DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in #PancreaticCancer advanced.onlinelibrary.wiley.com/doi/10.1002/...
Targeting Mast Cell Activation and MIF‐Mediated Remodelling Enhances Chemotherapy Response in #PancreaticCancer advanced.onlinelibrary.wiley.com/doi/10.1002/...
Targeting Mast Cell Activation and MIF‐Mediated Remodelling Enhances Chemotherapy Response in Pancreatic Cancer
Neoadjuvant gemcitabine plus nab-paclitaxel (AG) reprograms pancreatic ductal adenocarcinoma by shifting malignant cells toward a classical phenotype and remodeling the tumor microenvironment. Despit....
advanced.onlinelibrary.wiley.com
October 31, 2025 at 8:47 AM
Targeting Mast Cell Activation and MIF‐Mediated Remodelling Enhances Chemotherapy Response in #PancreaticCancer advanced.onlinelibrary.wiley.com/doi/10.1002/...
Fedora 43 is so cool—it’s my favorite #Linux distribution! @fedora.fosstodon.org.ap.brid.gy
October 30, 2025 at 7:48 PM
Fedora 43 is so cool—it’s my favorite #Linux distribution! @fedora.fosstodon.org.ap.brid.gy
Que ilusión re encontrarme con antiguos alumnos del grado de Biomedicina en el Máster de Terapias Avanzadas. Hay vocación investigadora falta apoyo y becas para darles la oportunidad #AcademicSky
October 28, 2025 at 6:49 PM
Que ilusión re encontrarme con antiguos alumnos del grado de Biomedicina en el Máster de Terapias Avanzadas. Hay vocación investigadora falta apoyo y becas para darles la oportunidad #AcademicSky
SLC7A11-specific CAR-T cell therapy potently targets colorectal and pancreatic cancer 🧪 www.sciencedirect.com/science/arti...
SLC7A11-specific CAR-T cell therapy potently targets colorectal and pancreatic cancer
SLC7A11 is highly expressed in various solid tumors, including colorectal cancer and pancreatic cancer. The aim of the study was to report the therape…
www.sciencedirect.com
October 28, 2025 at 2:47 PM
SLC7A11-specific CAR-T cell therapy potently targets colorectal and pancreatic cancer 🧪 www.sciencedirect.com/science/arti...
IGF2BP2 stabilized by USP7 promotes cancer-associated fibroblast activation and attenuates gemcitabine sensitivity in PDAC 🧪 www.sciencedirect.com/science/arti...
IGF2BP2 stabilized by USP7 promotes cancer-associated fibroblast activation and attenuates gemcitabine sensitivity in PDAC
N6-Methyladenosine (m6A) modification is a prevalent alteration in RNA, influencing stability, localization, and translation. The m6A reader IGF2BP2 s…
www.sciencedirect.com
October 28, 2025 at 2:43 PM
IGF2BP2 stabilized by USP7 promotes cancer-associated fibroblast activation and attenuates gemcitabine sensitivity in PDAC 🧪 www.sciencedirect.com/science/arti...
Synthetic Mimetics of Exosomal Lipid Profile Enhance Gemcitabine Delivery in Pancreatic Cancer www.biorxiv.org/content/10.1...
Synthetic Mimetics of Exosomal Lipid Profile Enhance Gemcitabine Delivery in Pancreatic Cancer
Pancreatic cancer ranks fourth among cancer-related deaths. Despite decades of research, the cure rate of disease remains disappointingly low. This dismal prognosis is due to late detection and to res...
www.biorxiv.org
October 28, 2025 at 8:43 AM
Synthetic Mimetics of Exosomal Lipid Profile Enhance Gemcitabine Delivery in Pancreatic Cancer www.biorxiv.org/content/10.1...
A blueprint for mutation-defined hallmark vulnerabilities across human cancers 🧬🖥️ www.biorxiv.org/content/10.1...
A blueprint for mutation-defined hallmark vulnerabilities across human cancers
Hallmark gene mutations shape cancer cell vulnerabilities and inform drug discovery. A systematic map of hallmark gene mutation-defined cancer dependencies and therapeutic responses is essential to un...
www.biorxiv.org
October 28, 2025 at 8:42 AM
A blueprint for mutation-defined hallmark vulnerabilities across human cancers 🧬🖥️ www.biorxiv.org/content/10.1...
Nischarin agonist rilmenidine shows antimetastatic potential in pancreatic ductal adenocarcinoma 🧪 www.biorxiv.org/content/10.1...
Nischarin agonist rilmenidine shows antimetastatic potential in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancer types with a dismal prognosis. Early metastatic dissemination and rich desmoplastic stroma limit therapeutic efficacy, and ...
www.biorxiv.org
October 28, 2025 at 8:41 AM
Nischarin agonist rilmenidine shows antimetastatic potential in pancreatic ductal adenocarcinoma 🧪 www.biorxiv.org/content/10.1...