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www.gla.ac.uk/colleges/mvl...

One of the key things to address when undertaking a feasibility study ahead of a trial is the acceptability of different aspects of the proposed trial (intervention, trial processes, proposed outcomes etc) to all relevant parties 1/7
#MethodologyMonday #125

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Research participants needed📢
Do you have experience recruiting patients into clinical trials in the UK and Ireland? Do you think recruitment targets are motivating? Are they communicated well? Then we would love to hear from you as a participant in our focus group study.

📢Research participants needed📢
Do you work in the field of clinical trials? We would love to hear from you as a participant in our focus group study or one-to-one interview to understand what enables and challenges us to make clinical trials greener.🌍

Every clinical trial is a puzzle. When participants drop out we lose pieces, and the picture becomes unclear 🧩.
Help to be part of the solution! 🗓️ Closing date: 16-May-2025. 📌
bit.ly/3RM0H0h

Do you work in clinical trials? Please take part in our survey that explores the practices of sharing recruitment and/or retention rates with recruiting sites to improve recruitment and/or retention behaviours: bit.ly/4jySw3C

So, as you have these (sometimes awkward) conversations about sample size, please do ensure that the clinical meaningfulness of the trial doesn’t get lost in the sample size samba beat!! 8/8

Whilst, of course, the trial has to be able to recruit the target number of patients, a trial must fundamentally be designed to deliver a clinically meaningful answer 4/8

We often hear of trials that show apparently clinically meaningful differences but did not detect these statistically. This is often because their sample size calculations were unrealistic - effect sizes set too large in an attempt to minimise the sample size 6/8

The term comes from the excellent Schulz & Grimes paper in the Lancet a number of years ago 3/8
www.thelancet.com/journals/lan...