After ~2 years of preparation, we’re all set for the @GordonConf on Fertilization! Excited for great talks, engaging discussions, and reconnecting face to face with this amazing team @ShwetaBhagwat3 @jovinelab.org & Rafael Fissore #GRC #Fertilization

4/6 And guess what? We demonstrated that calcium signals at fertilization function as a metabolic regulator, altering the availability of lactate and lactyl-CoA. This, in turn, affects H3K18la and impairs Pol I-driven EGA.

3/6 The answer came during our MATEbolism Journal Club, where we learned that lactylation acts as a molecular switch, linking metabolism and chromatin remodeling, and that H3K18-lactylation (H3K18la) and RNA pol-I activity are key for EGA and embryo development.

Hoy Argentina se lleno de orgullo 🇦🇷 🏳️‍🌈