Vikaas Sohal
@vikaassohal.bsky.social
Systems neuroscientist and psychiatrist at UCSF studying how inhibitory circuits and oscillations give rise to the emergent brain functions that underlie cognition and emotion.
LEGO mouse labyrinth so actually awesome x2
November 14, 2025 at 12:04 AM
LEGO mouse labyrinth so actually awesome x2
The second, led by Carlos Johnson-Cruz, compares PFC Ca2+ imaging in normal mice vs. mutants with reversible cognitive deficits. Task encoding (including outcome-encoding) normally reorganizes as mice learn new rules but becomes abnormally stable during perseveration: www.biorxiv.org/content/10.1...
Circuit inhibition promotes the dynamic reorganization of prefrontal task encoding to support cognitive flexibility
The mammalian prefrontal cortex encodes variables related to goal-directed behavior, and enables flexibility during environmental changes, making it critical to understand how the dynamic updating vs....
www.biorxiv.org
August 11, 2025 at 6:58 PM
The second, led by Carlos Johnson-Cruz, compares PFC Ca2+ imaging in normal mice vs. mutants with reversible cognitive deficits. Task encoding (including outcome-encoding) normally reorganizes as mice learn new rules but becomes abnormally stable during perseveration: www.biorxiv.org/content/10.1...
This work, made possible through a collaboration with the Schnitzer lab, shows that gamma oscillations are not unitary phenomena characterized by a microcircuit-wide pattern of entrainment, but rather comprise diverse motifs that are flexibly recruited to subserve specific behavioral functions.
August 11, 2025 at 6:58 PM
This work, made possible through a collaboration with the Schnitzer lab, shows that gamma oscillations are not unitary phenomena characterized by a microcircuit-wide pattern of entrainment, but rather comprise diverse motifs that are flexibly recruited to subserve specific behavioral functions.
This was followed by @viditavaidya.bsky.social hosting me at the legendary HutmentLab @tifrscience.bsky.social. It was super cool to see @rhythmicspikes.bsky.social's new lab at NCBS, before finishing my “tour” with Laxmi Rao at NIMHANS. Thanks all for this incredibly meaningful visit! 2/2
January 22, 2025 at 6:18 PM
This was followed by @viditavaidya.bsky.social hosting me at the legendary HutmentLab @tifrscience.bsky.social. It was super cool to see @rhythmicspikes.bsky.social's new lab at NCBS, before finishing my “tour” with Laxmi Rao at NIMHANS. Thanks all for this incredibly meaningful visit! 2/2
Finally, LiCl treatment, which we and the Rubenstein lab previously found rescues synaptic and behavioral abnormalities in Tbr1 cKO mice, also seems to reverse at least some of the observed abnormalities in neural activity. 4/n
January 22, 2025 at 6:13 PM
Finally, LiCl treatment, which we and the Rubenstein lab previously found rescues synaptic and behavioral abnormalities in Tbr1 cKO mice, also seems to reverse at least some of the observed abnormalities in neural activity. 4/n
Similar to our prior finding from Shank3 KO mice, multineuron coordination within social ensembles is diminished in Tbr1 cKO mice. The inability of neurons to act synergistically in order to encode social information via correlated activity may be a convergent feature of diverse autism models. 3/n
January 22, 2025 at 6:13 PM
Similar to our prior finding from Shank3 KO mice, multineuron coordination within social ensembles is diminished in Tbr1 cKO mice. The inability of neurons to act synergistically in order to encode social information via correlated activity may be a convergent feature of diverse autism models. 3/n
Using neural network classifiers, we found PFC social ensembles that undergo re- (and pre-) activation, plus ensembles which predict approach/avoidance decisions. These signals are all lost in Tbr1 cKO mice. 2/n
January 22, 2025 at 6:13 PM
Using neural network classifiers, we found PFC social ensembles that undergo re- (and pre-) activation, plus ensembles which predict approach/avoidance decisions. These signals are all lost in Tbr1 cKO mice. 2/n