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vgti.bsky.social
Vaccine & Gene Therapy Institute
@vgti.bsky.social
43 followers 44 following 79 posts
VGTI provides lifesaving solutions through transformative biomedical discovery and research, enabling the prevention and cure of global infectious diseases.
www.ohsu.edu/vaccine-gene-therapy-institute
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vgti.bsky.social
...can be used to evaluate immune and viral determinants of protection against cCMV.

Read more at:
pubmed.ncbi.nlm.nih.gov/41286406/
A rhesus macaque model of congenital cytomegalovirus infection reveals a spectrum of vertical transmission outcomes - PubMed
Congenital cytomegalovirus (cCMV) is the leading infectious cause of birth defects worldwide, yet immune determinants of protection to inform maternal vaccine design remain elusive due to the lack of a translational animal model. Here, we characterized the outcome of primary rhesus CMV (RhCMV) infec …
pubmed.ncbi.nlm.nih.gov
November 25, 2025 at 6:32 PM
vgti.bsky.social
Read more at: pubmed.ncbi.nlm.nih.gov/41134633/
A cytoplasmic motif in HLA-E that drives clathrin-mediated endocytosis and VCP-associated postendocytic trafficking - PubMed
Human Leukocyte Antigen E (HLA-E) is a nonclassical MHC class I molecule that exhibits dual immunological functions in regulating natural killer (NK) cells and T cells through unusual trafficking patterns. We previously reported that HLA-E surface expression is low and transient due to its cytoplasm …
pubmed.ncbi.nlm.nih.gov
October 28, 2025 at 4:44 PM
vgti.bsky.social
Read more at:
www.researchgate.net/publication/...
A Proof‐of‐Concept Phase 2a Partly Randomised Study Evaluating Leronlimab in Patients With Presumed Non‐Cirrhotic Metabolic Dysfunction–Associated Steatohepatitis | Request PDF
Request PDF | A Proof‐of‐Concept Phase 2a Partly Randomised Study Evaluating Leronlimab in Patients With Presumed Non‐Cirrhotic Metabolic Dysfunction–Associated Steatohepatitis | Chemokine receptor ty...
www.researchgate.net
October 21, 2025 at 4:22 PM
vgti.bsky.social
... and activate diverse host defenses.

Read more at:
pubmed.ncbi.nlm.nih.gov/41092897/
Primate resident memory T cells activate humoral and stromal immunity - PubMed
CD8<sup>+</sup> resident memory T (Trm) cells comprise a small population of frontline sentinels compared with the large tissues they surveil, making outsized contributions to immune protection from i...
pubmed.ncbi.nlm.nih.gov
October 20, 2025 at 5:56 PM
vgti.bsky.social
Read the full article here:
pubmed.ncbi.nlm.nih.gov/41004538/
Liver biopsies obtained throughout SIV infection reveal evolving interferon stimulated protein expression within distinct monocyte/macrophage subsets - PubMed
Liver dysfunction is more common and more severe among people with HIV than in the general population. Our previous transcriptomic analysis identified an increased hepatic type-1 interferon (IFN-1) re...
pubmed.ncbi.nlm.nih.gov
October 3, 2025 at 6:29 PM
vgti.bsky.social
...of the enzymes involved in their biosynthesis.

Read the full article here: pubmed.ncbi.nlm.nih.gov/40659247/
Integrated lipidomic and proteomic profiling reveals metabolic network disruption by SARS-CoV-2 variants - PubMed
The rapid evolution of SARS-CoV-2 has produced myriad viral strains with increasing transmissibility and capacity for immune evasion. While effective vaccination campaigns have reduced the fatalities ...
pubmed.ncbi.nlm.nih.gov
September 30, 2025 at 9:09 PM
vgti.bsky.social
...their potential antiviral activity, as typically prodrugs increase solubility and delivery. Additional studies are underway to elucidate the mechanism of action of these analogues.

Read the full article here: pubmed.ncbi.nlm.nih.gov/40939252/
Novel tricycle expanded purine nucleosides with pan-viral activity - PubMed
A series of thiophene-expanded tricyclic nucleosides featuring modifications not previously investigated, including sugar and nucleobase modifications, were synthesized as potential antiviral therapeu...
pubmed.ncbi.nlm.nih.gov
September 17, 2025 at 8:53 PM
vgti.bsky.social
In addition, MHC-E has a number of fascinating functions in regulating immunity that have many possible applications for the development of vaccines and immunotherapies against infectious diseases and cancer." -Klaus Früh, Ph.D.

Here is a link to the full text:
www.nature.com/articles/s41...
Targeting MHC-E as a new strategy for vaccines and immunotherapeutics - Nature Reviews Immunology
The dual nature of non-polymorphic MHC-E as a ligand for innate receptors and as an antigen-presenting protein raises the possibility of new, universally effective vaccines and immunotherapies for inf...
www.nature.com
September 4, 2025 at 5:03 PM
vgti.bsky.social
MHC-E is a non-classical MHC class I protein that has been studied for many years by the Oxford group and that we stumbled upon in our research on using cytomegalovirus as a novel vaccine vector. We found that T cells targeting MHC-E might be the key to the development of an AIDS vaccine
(continued)
September 4, 2025 at 5:03 PM
vgti.bsky.social
Read the full article here:
pubmed.ncbi.nlm.nih.gov/40862619/
Impact of obesity on the gut microbiome and inflammatory markers during SIV infection and antiretroviral therapy - PubMed
Dysbiosis and impaired gut barrier integrity contribute to chronic immune activation associated with both obesity and HIV infection. Given the increased incidence of obesity in people living with HIV,...
pubmed.ncbi.nlm.nih.gov
September 2, 2025 at 4:39 PM
vgti.bsky.social
... facilitates the development of safe and efficacious vaccines in humans.

Read the full article here:
academic.oup.com/jimmunol/art...
Glycoprotein L–deleted single-cycle rhesus cytomegalovirus vectors elicit MHC-E–restricted CD8+ T cells that protect against SIV
Abstract. Strain 68-1 rhesus CMV (RhCMV) vectors induce immune responses that mediate early, complete replication arrest of SIV infection in ∼60% of vaccin
academic.oup.com
August 29, 2025 at 9:37 PM
vgti.bsky.social
Incredible work by the Bimber, Okoye, Sacha, Estes, Axthelm, Streblow, Hansen, Picker lab teams with their contributors.

Read the full article here:

www.researchgate.net/publication/...
(PDF) An immune-focused supplemental alignment pipeline captures information missed from dominant single-cell RNA-seq analyses, including allele-specific MHC-I regulation
PDF | Introduction RNA sequencing (RNA-seq) can measure whole transcriptome gene expression from tissues or even individual cells, providing a powerful... | Find, read and cite all the research you ne...
www.researchgate.net
August 22, 2025 at 5:59 PM