Tejas Vettukattil
@vettukattil.bsky.social
Molecular Neuroscience.
There actually seems to at least be some research into TrkB agonists for the treatment of Alzheimer's. Here's one: www.ncbi.nlm.nih.gov/pmc/articles...
Though we don't have high quality clinical data yet.
Also important to note this isn't a psychedelic substance.
Though we don't have high quality clinical data yet.
Also important to note this isn't a psychedelic substance.
The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s ...
In this study, we used a prodrug strategy to improve the druggability of 7,8-DHF, which mimics the physiological actions of BDNF in a variety of animal models but with modest oral bioavailability, by ...
www.ncbi.nlm.nih.gov
September 16, 2023 at 11:35 AM
There actually seems to at least be some research into TrkB agonists for the treatment of Alzheimer's. Here's one: www.ncbi.nlm.nih.gov/pmc/articles...
Though we don't have high quality clinical data yet.
Also important to note this isn't a psychedelic substance.
Though we don't have high quality clinical data yet.
Also important to note this isn't a psychedelic substance.
It's unlikely that drugs that target TrkB would be particularly helpful in treating neurodegenerative diseases like Parkinson's or Alzheimer's, but there has been some discussion about treating stroke victims or general age related cognitive decline. We don't really know yet.
September 16, 2023 at 11:29 AM
It's unlikely that drugs that target TrkB would be particularly helpful in treating neurodegenerative diseases like Parkinson's or Alzheimer's, but there has been some discussion about treating stroke victims or general age related cognitive decline. We don't really know yet.
Here's the relevant paper of OXT 5-HT2CR receptor complexes: pubmed.ncbi.nlm.nih.gov/33188842/
Molecular, biochemical and behavioural evidence for a novel oxytocin receptor and serotonin 2C recep...
The complexity of oxytocin-mediated functions is strongly associated with its modulatory effects on other neurotransmission systems, including the serotonin (5-hydroxytryptamine, 5-HT) system. Signall...
pubmed.ncbi.nlm.nih.gov
September 12, 2023 at 6:35 AM
Here's the relevant paper of OXT 5-HT2CR receptor complexes: pubmed.ncbi.nlm.nih.gov/33188842/
I hope the results will be replicated and published soon. Previous studies have demonstrated how OXT and 5-HT2C oligomers can interact.
My data suggested these complexes were reduced in the hippocampus of rat depression models. With some evidence that Ketamine may restore 5-HT2C/OXTR interaction.
My data suggested these complexes were reduced in the hippocampus of rat depression models. With some evidence that Ketamine may restore 5-HT2C/OXTR interaction.
September 12, 2023 at 6:34 AM
I hope the results will be replicated and published soon. Previous studies have demonstrated how OXT and 5-HT2C oligomers can interact.
My data suggested these complexes were reduced in the hippocampus of rat depression models. With some evidence that Ketamine may restore 5-HT2C/OXTR interaction.
My data suggested these complexes were reduced in the hippocampus of rat depression models. With some evidence that Ketamine may restore 5-HT2C/OXTR interaction.
If everything goes to plan I'll be working in the Aguzzi lab in Zurich Switzerland, studying prion disease. It's a fair bit removed from my interests in psychiatry, but I'm really excited to learn new techniques and branch out a bit more.
September 12, 2023 at 6:22 AM
If everything goes to plan I'll be working in the Aguzzi lab in Zurich Switzerland, studying prion disease. It's a fair bit removed from my interests in psychiatry, but I'm really excited to learn new techniques and branch out a bit more.