Venkatesh Mallikarjun
@venkmallikarjun.bsky.social
Interested in ageing, transhumanism, systems biology and mixed martial arts. Senior Scientist at Altos Labs, Cambridge Institute. Views expressed here are my own. he/him
Reposted by Venkatesh Mallikarjun
The most successful grift of the modern era was convincing the smartest people in the world that 'changing the world' means optimizing the click-through rate on ads for mattresses that ship in a box
December 21, 2025 at 9:16 AM
The most successful grift of the modern era was convincing the smartest people in the world that 'changing the world' means optimizing the click-through rate on ads for mattresses that ship in a box
Reposted by Venkatesh Mallikarjun
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
October 1, 2025 at 6:21 PM
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
Reposted by Venkatesh Mallikarjun
Huntington’s disease successfully treated for first time. “An emotional research team became tearful as they described how data shows the disease was slowed by 75% in patients.” [bbc.com]
Huntington’s disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
www.bbc.com
September 24, 2025 at 6:42 PM
Huntington’s disease successfully treated for first time. “An emotional research team became tearful as they described how data shows the disease was slowed by 75% in patients.” [bbc.com]
Someone should start a B2B consultancy specialising in "Fixing your ruined company because you tried to replace your workforce with AI and now everything's fucked (you fucking idiot)".
August 24, 2025 at 6:10 PM
Someone should start a B2B consultancy specialising in "Fixing your ruined company because you tried to replace your workforce with AI and now everything's fucked (you fucking idiot)".
Reposted by Venkatesh Mallikarjun
With even less news coming out of Gaza due to an internet blackout & crowding out effects due to Israel's attack on Iran, it's essential to keep asking where things are, especially amid claims that aid is getting in via the Gaza Humanitarian Foundation.
Reporting confirms analysts' worst fears.
Reporting confirms analysts' worst fears.
EXCLUSIVE: American Security Contractor Unloads On US-Israeli ‘Gaza Humanitarian Foundation’
I thought I was signing up for an aid mission. But what I've witnessed in Gaza is horrific.
zeteo.com
June 16, 2025 at 3:40 PM
With even less news coming out of Gaza due to an internet blackout & crowding out effects due to Israel's attack on Iran, it's essential to keep asking where things are, especially amid claims that aid is getting in via the Gaza Humanitarian Foundation.
Reporting confirms analysts' worst fears.
Reporting confirms analysts' worst fears.
In an age where most tech "innovation" is about finding ways to surveil users to feed them ads or pointless billionaire pissing contests, this is the coolest fucking shit!
HOLY SHIT! This might be the coolest thing ever.
April 17, 2025 at 4:38 PM
In an age where most tech "innovation" is about finding ways to surveil users to feed them ads or pointless billionaire pissing contests, this is the coolest fucking shit!
Reposted by Venkatesh Mallikarjun
🚨 Preprint alert 🚨
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Ab-trapping - a peripheral staining artifact in antibody-based microscopy and genomics
Antibodies (Ab) are essential for detecting specific epitopes in microscopy and genomics, but can produce artifacts leading to erroneous interpretations. Here, we characterize a novel artifact, Ab-tra...
doi.org
April 14, 2025 at 8:08 PM
🚨 Preprint alert 🚨
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Reposted by Venkatesh Mallikarjun
"Building bridges" isn't possible while simultaneously refusing to name, condemn, or try to stop ongoing war crimes and genocide, not to mention occupation and apartheid medicine. This will be remembered as a profoundly cowardly, borderline collaborationist article to have published at this moment.
March 22, 2025 at 7:10 PM
"Building bridges" isn't possible while simultaneously refusing to name, condemn, or try to stop ongoing war crimes and genocide, not to mention occupation and apartheid medicine. This will be remembered as a profoundly cowardly, borderline collaborationist article to have published at this moment.
Reposted by Venkatesh Mallikarjun
Macrophages promote collagen deposition through circadian regulation of fibroblasts https://www.biorxiv.org/content/10.1101/2025.02.25.640115v1
February 26, 2025 at 11:30 AM
Macrophages promote collagen deposition through circadian regulation of fibroblasts https://www.biorxiv.org/content/10.1101/2025.02.25.640115v1
A tale as old as time. When subjected to the slightest incovenience, Conservatives will always throw their lot in with the far-right believing they can exert some kind of control over the resulting government, only to be consumed and dominated entirely.
Lessons to be learned:
1. Centrists align with far-right to look tough on immigration
2. Centrists gain nothing
3. Far-right wins more power
1. Centrists align with far-right to look tough on immigration
2. Centrists gain nothing
3. Far-right wins more power
January 31, 2025 at 9:49 PM
A tale as old as time. When subjected to the slightest incovenience, Conservatives will always throw their lot in with the far-right believing they can exert some kind of control over the resulting government, only to be consumed and dominated entirely.
Reposted by Venkatesh Mallikarjun
Our paper “A genome-wide atlas of human cell morphology” is finally out today in @naturemethods.bsky.social ! www.nature.com/articles/s41...
(I tweeted about our preprint in 2023 over at the bad place, but deactivated my account, so here we go again!)
(I tweeted about our preprint in 2023 over at the bad place, but deactivated my account, so here we go again!)
A genome-wide atlas of human cell morphology - Nature Methods
An optical pooled cell profiling platform (PERISCOPE) based on Cell Painting and optical sequencing of molecular barcodes was used to develop the first unbiased genome-wide morphology-based perturbati...
www.nature.com
January 27, 2025 at 6:23 PM
Our paper “A genome-wide atlas of human cell morphology” is finally out today in @naturemethods.bsky.social ! www.nature.com/articles/s41...
(I tweeted about our preprint in 2023 over at the bad place, but deactivated my account, so here we go again!)
(I tweeted about our preprint in 2023 over at the bad place, but deactivated my account, so here we go again!)
Reposted by Venkatesh Mallikarjun
American science and medicine has been thrown into chaos and uncertainty over the past week. Here are some stories to get up to speed. 1/12
January 28, 2025 at 3:58 AM
American science and medicine has been thrown into chaos and uncertainty over the past week. Here are some stories to get up to speed. 1/12