Velmeshev lab
@velmeshevlab.bsky.social
Velmeshev lab at Duke University. We study brain development and are into single-cell genomics, spatial transcriptomics and barcoded viral tracing.
https://www.velmeshevlab.com
https://www.velmeshevlab.com
Our paper on cell type-specific changes in dup15q syndrome during development and in the adult human brain is out in NatureComms: nature.com/articles/s41.... Thanks to the co-first author Yonatan Perez,
my mentor Arnold Kriegstein
and all authors. Special thanks to donors and AutismBrainNet.
my mentor Arnold Kriegstein
and all authors. Special thanks to donors and AutismBrainNet.
Single-cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism - Nature Communications
Single-cell analysis of patient brains and cortical organoids links disrupted developmental metabolic reprogramming to postnatal synaptic dysfunction in dup15q syndrome, revealing shared neuronal chan...
nature.com
July 10, 2025 at 4:58 AM
Our paper on cell type-specific changes in dup15q syndrome during development and in the adult human brain is out in NatureComms: nature.com/articles/s41.... Thanks to the co-first author Yonatan Perez,
my mentor Arnold Kriegstein
and all authors. Special thanks to donors and AutismBrainNet.
my mentor Arnold Kriegstein
and all authors. Special thanks to donors and AutismBrainNet.
Reposted by Velmeshev lab
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature
HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...
www.nature.com
May 14, 2025 at 4:09 PM
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
Reposted by Velmeshev lab
Delighted to share our most recent preprint led by the incredible @MilJessenya and @Jalbsoto! In this study, we generated a metabolomic atlas of human cortical development and discovered that the pentose phosphate pathway regulates radial glia cell fate. www.biorxiv.org/content/10.1...
Metabolic Atlas of Early Human Cortex Identifies Regulators of Cell Fate Transitions
Characterization of cell type emergence during human cortical development, which enables unique human cognition, has focused primarily on anatomical and transcriptional characterizations. Metabolic pr...
www.biorxiv.org
March 13, 2025 at 4:36 AM
Delighted to share our most recent preprint led by the incredible @MilJessenya and @Jalbsoto! In this study, we generated a metabolomic atlas of human cortical development and discovered that the pentose phosphate pathway regulates radial glia cell fate. www.biorxiv.org/content/10.1...
Reposted by Velmeshev lab
Recruiting a postdoc! State-dependent regulation of social behavior & social group dynamics using in vivo deep brain calcium imaging, machine learning, etc... all the circuit tools. Applicants can email me directly if interested and apply here: academicjobsonline.org/ajo/jobs/29799.
Duke University, Psychology and Neuroscience
Job #AJO29799, Postdoctoral Associate, Psychology and Neuroscience, Duke University, Durham, North Carolina, US
academicjobsonline.org
February 28, 2025 at 5:04 PM
Recruiting a postdoc! State-dependent regulation of social behavior & social group dynamics using in vivo deep brain calcium imaging, machine learning, etc... all the circuit tools. Applicants can email me directly if interested and apply here: academicjobsonline.org/ajo/jobs/29799.
Reposted by Velmeshev lab
Reaching out to all Americans through the media to explain how decreasing funding of the NIH will have irreversible harm for developing therapies for all diseases. Please spread the word to your families and friends and contact your congressional representatives.
www.nbcnews.com/science/scie...
www.nbcnews.com/science/scie...
Science under siege: Trump cuts threaten to undermine decades of research
Sweeping layoffs, funding freezes and executive orders have provoked outcry among federal researchers and their university partners, who fear that science itself is under siege.
www.nbcnews.com
February 20, 2025 at 5:43 PM
Reaching out to all Americans through the media to explain how decreasing funding of the NIH will have irreversible harm for developing therapies for all diseases. Please spread the word to your families and friends and contact your congressional representatives.
www.nbcnews.com/science/scie...
www.nbcnews.com/science/scie...