vdoye.bsky.social
@vdoye.bsky.social
🔍 Our hypothesis: the structural integrity of the nuclear pore scaffold, which exhibits a certain elasticity, plays a protective role for the nuclear envelope. This may explain why genetic diseases linked to some nuclear pore components only target specific cell types or organs
April 11, 2025 at 12:48 PM
Their trick: a 3D template matching approach to push cryo-electron tomography beyond classical subtomogram averages and analyze individual pores complexes.
April 11, 2025 at 12:48 PM
Have a look at the unexpected architecture of nuclear pores without Nup133: altered symmetries, incomplete ring assemblies and a trend to dismantle giving rise to large openings upon neural differentiation ⬇️
April 11, 2025 at 12:48 PM
👏 Congratulation to Reiya Taniguchi for the impressive work and to @corniacki.bsky.social who initiated this collaboration.
April 11, 2025 at 12:48 PM