These data lay the groundwork to dig deeper into this process because if we can block egress, this kills the parasite! You can read more about this here (we welcome any/all feedback you may have):
www.biorxiv.org/content/10.1...

She observed that exocytosis begins several hours prior to daughter parasite formation. There is a second signal that results in membrane rupture, which only happens at one site (magenta signal, in video). She also identified a calcium-binding protein that is required for vesicle exocytosis.

Dr. Dedkhad decided to focus on a key process, vesicle exocytosis, that was posited to be critical for membrane rupture. She targeted a reporter to specific vesicles in the malaria parasite that are secreted in response to the egress signal (gray signal, in video).

Exiting the host has to be timed perfectly. Leave too soon, you die, leave too late, your daughter cells are exhausted and die. The timing of how the parasite decides to blow up its home to exit is murky.

Thanks Abhinay! And with the newly vested proFessorial authority, i do hereby proclaim dosas to be superior in all aspects!

Thanks Sabrina! Finding friends like you has been a big highlight and one of the reasons why i love academia

Thanks Ira! Couldn't have done it without our wonderful community!

Don't give them ideas, Rob!! 😅

It’s just personal preference my guy. I have never liked idlis. My dislike doesn’t inhibit your enjoyment of idlis 😁

I mean if you like a mouthful of barely cooked batter… vs a crispy delicious crepe with endless variations of fillings!

My ancestors would turn in their graves if they had one.