VU Chemical Biology
@vanderbiltvicb.bsky.social
The Vanderbilt Institute of Chemical Biology's mission is to harness the power of chemistry to improve human health.
Pinned
The VICB and St. Jude CBT have launched a new monthly trainee-led research series, CBT & VICB Trainee Talks, bringing together graduate students and postdocs from both institutions to share research and build collaborations.
For details, contact: tia.repscher@vanderbilt.edu
For details, contact: tia.repscher@vanderbilt.edu
VICB member Neil Osheroff was featured on Biochemistry’s “Most Read” list for two publications:
• Mechanism of Quinolone Action and Resistance (1 month)
• Amsacrine as a Topoisomerase II Poison (12 months)
#monday #research #vanderbilt #university #academic #discovery #published #featured
• Mechanism of Quinolone Action and Resistance (1 month)
• Amsacrine as a Topoisomerase II Poison (12 months)
#monday #research #vanderbilt #university #academic #discovery #published #featured
November 10, 2025 at 5:40 PM
VICB member Neil Osheroff was featured on Biochemistry’s “Most Read” list for two publications:
• Mechanism of Quinolone Action and Resistance (1 month)
• Amsacrine as a Topoisomerase II Poison (12 months)
#monday #research #vanderbilt #university #academic #discovery #published #featured
• Mechanism of Quinolone Action and Resistance (1 month)
• Amsacrine as a Topoisomerase II Poison (12 months)
#monday #research #vanderbilt #university #academic #discovery #published #featured
JOIN US this Wednesday for our VICB seminar featuring Dr. Hong!
Join us for the next VICB Seminar with Mei Hong (MIT)
🧠 “Deconstructing and Reconstructing Tau by Solid-State NMR”
📅 Wed, Nov 12 | 🕛 12:15 PM | 📍 1220 MRB III
#VICB #Vanderbilt #ChemicalBiology #NMR #Neuroscience
🧠 “Deconstructing and Reconstructing Tau by Solid-State NMR”
📅 Wed, Nov 12 | 🕛 12:15 PM | 📍 1220 MRB III
#VICB #Vanderbilt #ChemicalBiology #NMR #Neuroscience
November 10, 2025 at 2:38 PM
JOIN US this Wednesday for our VICB seminar featuring Dr. Hong!
Join us for the VICB Annual Student Research Symposium!
🗓 Sept 11, 2026 | 🕗 8AM–5PM
📍 Vanderbilt University Student Life Center
Keynote: Craig Crews, Ph.D. (Yale University)
#VICB #Vanderbilt #ChemicalBiology #DrugDiscovery #Research #Symposium
🗓 Sept 11, 2026 | 🕗 8AM–5PM
📍 Vanderbilt University Student Life Center
Keynote: Craig Crews, Ph.D. (Yale University)
#VICB #Vanderbilt #ChemicalBiology #DrugDiscovery #Research #Symposium
November 7, 2025 at 2:57 PM
Join us for the VICB Annual Student Research Symposium!
🗓 Sept 11, 2026 | 🕗 8AM–5PM
📍 Vanderbilt University Student Life Center
Keynote: Craig Crews, Ph.D. (Yale University)
#VICB #Vanderbilt #ChemicalBiology #DrugDiscovery #Research #Symposium
🗓 Sept 11, 2026 | 🕗 8AM–5PM
📍 Vanderbilt University Student Life Center
Keynote: Craig Crews, Ph.D. (Yale University)
#VICB #Vanderbilt #ChemicalBiology #DrugDiscovery #Research #Symposium
Join us for the next VICB Seminar with Mei Hong (MIT)
🧠 “Deconstructing and Reconstructing Tau by Solid-State NMR”
📅 Wed, Nov 12 | 🕛 12:15 PM | 📍 1220 MRB III
#VICB #Vanderbilt #ChemicalBiology #NMR #Neuroscience
🧠 “Deconstructing and Reconstructing Tau by Solid-State NMR”
📅 Wed, Nov 12 | 🕛 12:15 PM | 📍 1220 MRB III
#VICB #Vanderbilt #ChemicalBiology #NMR #Neuroscience
November 7, 2025 at 2:53 PM
Join us for the next VICB Seminar with Mei Hong (MIT)
🧠 “Deconstructing and Reconstructing Tau by Solid-State NMR”
📅 Wed, Nov 12 | 🕛 12:15 PM | 📍 1220 MRB III
#VICB #Vanderbilt #ChemicalBiology #NMR #Neuroscience
🧠 “Deconstructing and Reconstructing Tau by Solid-State NMR”
📅 Wed, Nov 12 | 🕛 12:15 PM | 📍 1220 MRB III
#VICB #Vanderbilt #ChemicalBiology #NMR #Neuroscience
The VICB and St. Jude CBT have launched a new monthly trainee-led research series, CBT & VICB Trainee Talks, bringing together graduate students and postdocs from both institutions to share research and build collaborations.
For details, contact: tia.repscher@vanderbilt.edu
For details, contact: tia.repscher@vanderbilt.edu
November 5, 2025 at 2:59 PM
The VICB and St. Jude CBT have launched a new monthly trainee-led research series, CBT & VICB Trainee Talks, bringing together graduate students and postdocs from both institutions to share research and build collaborations.
For details, contact: tia.repscher@vanderbilt.edu
For details, contact: tia.repscher@vanderbilt.edu
Join us TODAY in room 1200 MRB III at 12:15pm for a seminar from Danette Daniels!
Join us this WEDNESDAY, November 5, as the
@vanderbilt.edu
Institute of Chemical Biology (VICB) Seminar #Series continues!
@vanderbilt.edu
Institute of Chemical Biology (VICB) Seminar #Series continues!
November 5, 2025 at 2:50 PM
Join us TODAY in room 1200 MRB III at 12:15pm for a seminar from Danette Daniels!
Join us this WEDNESDAY, November 5, as the
@vanderbilt.edu
Institute of Chemical Biology (VICB) Seminar #Series continues!
@vanderbilt.edu
Institute of Chemical Biology (VICB) Seminar #Series continues!
November 3, 2025 at 3:16 PM
Join us this WEDNESDAY, November 5, as the
@vanderbilt.edu
Institute of Chemical Biology (VICB) Seminar #Series continues!
@vanderbilt.edu
Institute of Chemical Biology (VICB) Seminar #Series continues!
A recent study from ZJ Yang Lab examines how structural flexibility contributes to cold adaptation in cellulases.
Read more:
www.vanderbilt.edu/csb/2025/10/...
Read more:
www.vanderbilt.edu/csb/2025/10/...
Sometimes space is a good thing: uncovering the structural determinants of cold adaptation in cellulases
By Cameron I. Cohen Cellulases are enzymes responsible for the hydrolysis of glycosidic bonds in cellulose, a polysaccharide which serves as the main structural material in plant cell walls. The effic...
www.vanderbilt.edu
November 3, 2025 at 3:14 PM
A recent study from ZJ Yang Lab examines how structural flexibility contributes to cold adaptation in cellulases.
Read more:
www.vanderbilt.edu/csb/2025/10/...
Read more:
www.vanderbilt.edu/csb/2025/10/...
Congratulations to Mayme Van Meveren (Fesik Lab) and Yilin Yang (Lau Lab, CDB) on receiving Vanderbilt’s Research Excellence Award at the 2025 Fall Staff Assembly.
Their contributions reflect the dedication and scientific excellence that define the VICB community.
Their contributions reflect the dedication and scientific excellence that define the VICB community.
October 31, 2025 at 2:57 PM
Congratulations to Mayme Van Meveren (Fesik Lab) and Yilin Yang (Lau Lab, CDB) on receiving Vanderbilt’s Research Excellence Award at the 2025 Fall Staff Assembly.
Their contributions reflect the dedication and scientific excellence that define the VICB community.
Their contributions reflect the dedication and scientific excellence that define the VICB community.
Reposted by VU Chemical Biology
@vanderbilt.edu and Ancora Innovations continue their collaboration to advance translational research and health care innovation.
VICB recognizes the importance of partnerships that connect discovery with real-world impact.
Learn more: bit.ly/47T1ZOP
VICB recognizes the importance of partnerships that connect discovery with real-world impact.
Learn more: bit.ly/47T1ZOP
Vanderbilt’s Ancora Partnership: A collaborative journey toward health care innovation
Since the inception of the Ancora Innovations partnership in 2018, Vanderbilt and Deerfield Management have enjoyed a robust collaboration. Deerfield’s commitment includes significant support for adva...
bit.ly
October 29, 2025 at 3:48 PM
@vanderbilt.edu and Ancora Innovations continue their collaboration to advance translational research and health care innovation.
VICB recognizes the importance of partnerships that connect discovery with real-world impact.
Learn more: bit.ly/47T1ZOP
VICB recognizes the importance of partnerships that connect discovery with real-world impact.
Learn more: bit.ly/47T1ZOP
Reposted by VU Chemical Biology
Join us Wed, Nov 5 for the next VICB Seminar!
🧬 Dr. Danette Daniels (Foghorn Therapeutics) presents:
“Towards New Cancer Medicines with Degraders of Chromatin Regulatory Proteins”
🕛 12:15PM | 📍1220 MRB III
🧬 Dr. Danette Daniels (Foghorn Therapeutics) presents:
“Towards New Cancer Medicines with Degraders of Chromatin Regulatory Proteins”
🕛 12:15PM | 📍1220 MRB III
October 22, 2025 at 3:09 PM
Join us Wed, Nov 5 for the next VICB Seminar!
🧬 Dr. Danette Daniels (Foghorn Therapeutics) presents:
“Towards New Cancer Medicines with Degraders of Chromatin Regulatory Proteins”
🕛 12:15PM | 📍1220 MRB III
🧬 Dr. Danette Daniels (Foghorn Therapeutics) presents:
“Towards New Cancer Medicines with Degraders of Chromatin Regulatory Proteins”
🕛 12:15PM | 📍1220 MRB III
Reposted by VU Chemical Biology
🎉 Congratulations to the faculty members in our school on their recent appointments and promotions! These individuals significantly enrich our pursuit of pathbreaking research and contribute to the growth and success of our school. 👏🏻👏🏼👏🏽👏🏾👏🏿 medschool.vanderbilt.edu/basic-scienc...
Celebrating appointments and promotions in the School of Medicine Basic Sciences: July–September 2025
Congratulations to our School of Medicine Basic Sciences faculty members who were promoted or received new appointments between July and September 2025. These individuals significantly enrich our p…
medschool.vanderbilt.edu
October 25, 2025 at 3:45 AM
🎉 Congratulations to the faculty members in our school on their recent appointments and promotions! These individuals significantly enrich our pursuit of pathbreaking research and contribute to the growth and success of our school. 👏🏻👏🏼👏🏽👏🏾👏🏿 medschool.vanderbilt.edu/basic-scienc...
Reposted by VU Chemical Biology
💛 Your pride looks good in Vandyprint! When you make a gift to the School of Medicine Basic Sciences by Nov. 9, you’ll get a limited-edition thank-you gift to show our appreciation. Every contribution helps support our community!
Fall Incentive 2025
Join me and make a gift to Vanderbilt
give.vanderbilt.edu
October 25, 2025 at 7:15 PM
💛 Your pride looks good in Vandyprint! When you make a gift to the School of Medicine Basic Sciences by Nov. 9, you’ll get a limited-edition thank-you gift to show our appreciation. Every contribution helps support our community!
@vanderbilt.edu and Ancora Innovations continue their collaboration to advance translational research and health care innovation.
VICB recognizes the importance of partnerships that connect discovery with real-world impact.
Learn more: bit.ly/47T1ZOP
VICB recognizes the importance of partnerships that connect discovery with real-world impact.
Learn more: bit.ly/47T1ZOP
Vanderbilt’s Ancora Partnership: A collaborative journey toward health care innovation
Since the inception of the Ancora Innovations partnership in 2018, Vanderbilt and Deerfield Management have enjoyed a robust collaboration. Deerfield’s commitment includes significant support for adva...
bit.ly
October 29, 2025 at 3:48 PM
@vanderbilt.edu and Ancora Innovations continue their collaboration to advance translational research and health care innovation.
VICB recognizes the importance of partnerships that connect discovery with real-world impact.
Learn more: bit.ly/47T1ZOP
VICB recognizes the importance of partnerships that connect discovery with real-world impact.
Learn more: bit.ly/47T1ZOP
Reposted by VU Chemical Biology
🔬 Introducing TrueSpot, a new algorithmic tool that’s poised to revolutionize microscopy image analysis across biology and medicine. Developed in Gregor Neuert’s lab, TrueSpot automates detection and quantification of fluorescent “spots” in 2D & 3D images. medschool.vanderbilt.edu/basic-scienc...
New algorithmic tool can improve microscopy image analysis, making improvements across fields
A new image analysis tool called TrueSpot has the capacity to overhaul the quantity and quality of usable data that can be obtained from fluorescence microscopy, which is used across an enormous ra…
medschool.vanderbilt.edu
October 9, 2025 at 4:15 PM
🔬 Introducing TrueSpot, a new algorithmic tool that’s poised to revolutionize microscopy image analysis across biology and medicine. Developed in Gregor Neuert’s lab, TrueSpot automates detection and quantification of fluorescent “spots” in 2D & 3D images. medschool.vanderbilt.edu/basic-scienc...
Reposted by VU Chemical Biology
🧬 Few genes wield as much power or mystery as MYC, a key driver of #cancer cell growth and survival. Stephen Fesik and William Tansey are uncovering how MYC reprograms cells and why it’s one of the most challenging yet promising targets in oncology. 👉 medschool.vanderbilt.edu/basic-scienc...
The emperor of all oncogenes
Professor of Cell and Developmental Biology William Tansey and Professor of Biochemistry Stephen Fesik are rewriting the playbook for defeating cancer. After ten years of research, the two School o…
medschool.vanderbilt.edu
October 16, 2025 at 7:30 PM
🧬 Few genes wield as much power or mystery as MYC, a key driver of #cancer cell growth and survival. Stephen Fesik and William Tansey are uncovering how MYC reprograms cells and why it’s one of the most challenging yet promising targets in oncology. 👉 medschool.vanderbilt.edu/basic-scienc...
Reposted by VU Chemical Biology
💻 Ben Brown takes on one of the biggest roadblocks to using AI in this field: how to accurately model the complex interactions between drugs and their protein targets. Learn more about his new targeted approach 👉
Vanderbilt scientist tackles key roadblock for AI in drug discovery
Vanderbilt’s Dr. Benjamin P. Brown is improving the way the field of drug discovery creates machine learning algorithms to predict a protein’s interactions with a small molecule. These improvements…
medschool.vanderbilt.edu
October 17, 2025 at 4:09 PM
💻 Ben Brown takes on one of the biggest roadblocks to using AI in this field: how to accurately model the complex interactions between drugs and their protein targets. Learn more about his new targeted approach 👉
Reposted by VU Chemical Biology
🎓👏 Join us in honoring dean emeritus Larry Marnett, whose five decades of dedication to science, leadership, and mentorship was highlighted during a reunion of 70+ former trainees from around the globe.
Read more about this tribute 👉 medschool.vanderbilt.edu/basic-scienc...
Read more about this tribute 👉 medschool.vanderbilt.edu/basic-scienc...
From Lab to Legacy: Marnett’s Trainees Gather to Toast a Life in Science and Service
In a heartwarming tribute to a remarkable career, more than 70 of his former graduate students and postdoctoral scholars recently traveled from across the globe for a three-day festivity on Oct. 3–…
medschool.vanderbilt.edu
October 22, 2025 at 4:15 PM
🎓👏 Join us in honoring dean emeritus Larry Marnett, whose five decades of dedication to science, leadership, and mentorship was highlighted during a reunion of 70+ former trainees from around the globe.
Read more about this tribute 👉 medschool.vanderbilt.edu/basic-scienc...
Read more about this tribute 👉 medschool.vanderbilt.edu/basic-scienc...
Reposted by VU Chemical Biology
🎃 Halloween is right around the corner and every year, Chuck Sanders sits down with a very special guest...This Halloween, his annual eerie interview features none other than Maud Menten, co-creator of the legendary Michaelis-Menten enzyme kinetics. 🧪 medschool.vanderbilt.edu/basic-scienc...
A Halloween interview with Maud Menten
Tune in to Professor of Biochemistry Chuck Sanders' yearly Halloween interview, this year featuring Maud Menten, co-creator of the Michaelis-Menten enzyme kinetics equation.
medschool.vanderbilt.edu
October 23, 2025 at 8:07 PM
🎃 Halloween is right around the corner and every year, Chuck Sanders sits down with a very special guest...This Halloween, his annual eerie interview features none other than Maud Menten, co-creator of the legendary Michaelis-Menten enzyme kinetics. 🧪 medschool.vanderbilt.edu/basic-scienc...
Colleagues and former trainees gathered to honor Dr. Larry J. Marnett, Dean Emeritus, Distinguished Professor, and founding leader of the Vanderbilt Institute of Chemical Biology (VICB).
Celebrating 50 years.
🔗 Read more: bit.ly/4nhbP2w
@vanderbilt.edu @vubasicsciences.bsky.social #wednesday
Celebrating 50 years.
🔗 Read more: bit.ly/4nhbP2w
@vanderbilt.edu @vubasicsciences.bsky.social #wednesday
From lab to legacy: Marnett’s trainees gather to toast a life in science and service
In a heartwarming tribute to a remarkable career, more than 70 of his former graduate students and postdoctoral scholars recently traveled from across the globe for a three-day festivity on Oct. 3–5 t...
bit.ly
October 22, 2025 at 6:09 PM
Colleagues and former trainees gathered to honor Dr. Larry J. Marnett, Dean Emeritus, Distinguished Professor, and founding leader of the Vanderbilt Institute of Chemical Biology (VICB).
Celebrating 50 years.
🔗 Read more: bit.ly/4nhbP2w
@vanderbilt.edu @vubasicsciences.bsky.social #wednesday
Celebrating 50 years.
🔗 Read more: bit.ly/4nhbP2w
@vanderbilt.edu @vubasicsciences.bsky.social #wednesday
Join us Wed, Nov 5 for the next VICB Seminar!
🧬 Dr. Danette Daniels (Foghorn Therapeutics) presents:
“Towards New Cancer Medicines with Degraders of Chromatin Regulatory Proteins”
🕛 12:15PM | 📍1220 MRB III
🧬 Dr. Danette Daniels (Foghorn Therapeutics) presents:
“Towards New Cancer Medicines with Degraders of Chromatin Regulatory Proteins”
🕛 12:15PM | 📍1220 MRB III
October 22, 2025 at 3:09 PM
Join us Wed, Nov 5 for the next VICB Seminar!
🧬 Dr. Danette Daniels (Foghorn Therapeutics) presents:
“Towards New Cancer Medicines with Degraders of Chromatin Regulatory Proteins”
🕛 12:15PM | 📍1220 MRB III
🧬 Dr. Danette Daniels (Foghorn Therapeutics) presents:
“Towards New Cancer Medicines with Degraders of Chromatin Regulatory Proteins”
🕛 12:15PM | 📍1220 MRB III
Vanderbilt scientists are tackling a major hurdle for AI in drug discovery and improving model reliability for new protein targets.
🔗https://medschool.vanderbilt.edu/basic-sciences/2025/10/16/vanderbilt-scientist-tackles-key-roadblock-for-ai-in-drug-discovery/
🔗https://medschool.vanderbilt.edu/basic-sciences/2025/10/16/vanderbilt-scientist-tackles-key-roadblock-for-ai-in-drug-discovery/
October 20, 2025 at 2:04 PM
Vanderbilt scientists are tackling a major hurdle for AI in drug discovery and improving model reliability for new protein targets.
🔗https://medschool.vanderbilt.edu/basic-sciences/2025/10/16/vanderbilt-scientist-tackles-key-roadblock-for-ai-in-drug-discovery/
🔗https://medschool.vanderbilt.edu/basic-sciences/2025/10/16/vanderbilt-scientist-tackles-key-roadblock-for-ai-in-drug-discovery/
Recent VICB-affiliated papers span molecular mechanisms to novel therapeutics:
• BTK autoinhibition (PNAS)
• Eye tissue imaging mass spectrometry (Analytical Chemistry)
and more!
medschool.vanderbilt.edu/vicb/publica...
@vanderbilt.edu @vubasicsciences.bsky.social #Monday #research #vanderbilt
• BTK autoinhibition (PNAS)
• Eye tissue imaging mass spectrometry (Analytical Chemistry)
and more!
medschool.vanderbilt.edu/vicb/publica...
@vanderbilt.edu @vubasicsciences.bsky.social #Monday #research #vanderbilt
Publications
Latest Publications BTK autoinhibition analyzed by high-throughput swaps of SH2 domains. Proceedings of the National Academy of Sciences.Timothy Eisen*, Chien-Lun Hung, John Kuriyan*. Advanced Dimensionality Reduction for Imaging Mass Spectrometry of Human Eye Tissue through Low-Rank Modeling with Sparse and Dense Residuals. Analytical Chemistry.Roger Moens* (Delft University of Technology), David Anderson, Richard Caprioli, Christine Curcio, […]
medschool.vanderbilt.edu
October 20, 2025 at 2:03 PM
Recent VICB-affiliated papers span molecular mechanisms to novel therapeutics:
• BTK autoinhibition (PNAS)
• Eye tissue imaging mass spectrometry (Analytical Chemistry)
and more!
medschool.vanderbilt.edu/vicb/publica...
@vanderbilt.edu @vubasicsciences.bsky.social #Monday #research #vanderbilt
• BTK autoinhibition (PNAS)
• Eye tissue imaging mass spectrometry (Analytical Chemistry)
and more!
medschool.vanderbilt.edu/vicb/publica...
@vanderbilt.edu @vubasicsciences.bsky.social #Monday #research #vanderbilt
Reposted by VU Chemical Biology
VICB is pleased to announce a collaboration with the
Carl R. Woese Institute for Genomic Biology in introducing LassoESM, a new language model designed to predict properties of lasso peptides.
@vubasicsciences.bsky.social @vanderbilt.edu #research #biology #collaboration #university
Carl R. Woese Institute for Genomic Biology in introducing LassoESM, a new language model designed to predict properties of lasso peptides.
@vubasicsciences.bsky.social @vanderbilt.edu #research #biology #collaboration #university
Meet LassoESM, a lasso peptide-tailored protein language model developed by a team from the Carl R. Woese Institute for Genomic Biology. ChBE professor Diwakar Shukla, project co-leader, has provided valuable insights into machine learning knowledge.
chbe.illinois.edu/news/stories...
chbe.illinois.edu/news/stories...
Learning the language of lasso peptides to improve peptide engineering
Learning the language of lasso peptides to improve peptide engineering
chbe.illinois.edu
October 9, 2025 at 2:01 PM
VICB is pleased to announce a collaboration with the
Carl R. Woese Institute for Genomic Biology in introducing LassoESM, a new language model designed to predict properties of lasso peptides.
@vubasicsciences.bsky.social @vanderbilt.edu #research #biology #collaboration #university
Carl R. Woese Institute for Genomic Biology in introducing LassoESM, a new language model designed to predict properties of lasso peptides.
@vubasicsciences.bsky.social @vanderbilt.edu #research #biology #collaboration #university