Kalev Freeman
@uvmtraumalab.bsky.social
Can we resuscitate damaged endothelium after injury? | Physician-scientist studying small blood vessels and trauma physiology at the University of Vermont 🚑 | Father, dog-lover, snow-sport enthusiast, and bluegrass fiddle player 🎻
Study abroad in the #Galápagos Islands for spring break 2026!
Earn 3 credits & travel to spectacular locations with #UVM faculty for hands-on exploration of the unique biodiversity in #Ecuador.
Spots are limited, inquire today at goabroad.uvm.edu/index.cfm?Fu...
@uvmvermont.bsky.social
Earn 3 credits & travel to spectacular locations with #UVM faculty for hands-on exploration of the unique biodiversity in #Ecuador.
Spots are limited, inquire today at goabroad.uvm.edu/index.cfm?Fu...
@uvmvermont.bsky.social
November 3, 2025 at 8:36 PM
Study abroad in the #Galápagos Islands for spring break 2026!
Earn 3 credits & travel to spectacular locations with #UVM faculty for hands-on exploration of the unique biodiversity in #Ecuador.
Spots are limited, inquire today at goabroad.uvm.edu/index.cfm?Fu...
@uvmvermont.bsky.social
Earn 3 credits & travel to spectacular locations with #UVM faculty for hands-on exploration of the unique biodiversity in #Ecuador.
Spots are limited, inquire today at goabroad.uvm.edu/index.cfm?Fu...
@uvmvermont.bsky.social
October 31, 2025 at 10:16 AM
October 18, 2025 at 2:41 PM
October 18, 2025 at 2:38 PM
In their juvenile stage, terrestrial Eastern Newts (Notophthalmus viridescens), also known as red efts, produce tetrodotoxin, the same NaV channel blocking-neurotoxin as pufferfish. The striking coloration is an aposematism.
#Toxicology #toxsky #emsky #NeuroSky #ionchannels #electrophysiology
#Toxicology #toxsky #emsky #NeuroSky #ionchannels #electrophysiology
September 29, 2025 at 2:06 AM
In their juvenile stage, terrestrial Eastern Newts (Notophthalmus viridescens), also known as red efts, produce tetrodotoxin, the same NaV channel blocking-neurotoxin as pufferfish. The striking coloration is an aposematism.
#Toxicology #toxsky #emsky #NeuroSky #ionchannels #electrophysiology
#Toxicology #toxsky #emsky #NeuroSky #ionchannels #electrophysiology
September 27, 2025 at 10:45 PM
Chillin’ out! Even border collies need to take a break sometimes.
#bordercollies #dogsofbluesky #chillaxing #vermont
#bordercollies #dogsofbluesky #chillaxing #vermont
September 7, 2025 at 11:50 AM
Chillin’ out! Even border collies need to take a break sometimes.
#bordercollies #dogsofbluesky #chillaxing #vermont
#bordercollies #dogsofbluesky #chillaxing #vermont
VIP guests visiting the lab and my all-star team of scientists today. #MedSky #AcademicSky #Scienceiscool #UVMLarnerMed
July 16, 2025 at 7:13 PM
VIP guests visiting the lab and my all-star team of scientists today. #MedSky #AcademicSky #Scienceiscool #UVMLarnerMed
June 21, 2025 at 1:40 PM
June 7, 2025 at 5:46 PM
It’s great to be back in Boston for 48th Annual Conference on Shock, with talented pre-med and grad students from @uvmvermont.bsky.social.
Continuing our tradition of sushi dinner with the lab and friends at the meeting.
#SHOCKCON25 #UVMLarnerMed
Continuing our tradition of sushi dinner with the lab and friends at the meeting.
#SHOCKCON25 #UVMLarnerMed
June 2, 2025 at 3:56 PM
It’s great to be back in Boston for 48th Annual Conference on Shock, with talented pre-med and grad students from @uvmvermont.bsky.social.
Continuing our tradition of sushi dinner with the lab and friends at the meeting.
#SHOCKCON25 #UVMLarnerMed
Continuing our tradition of sushi dinner with the lab and friends at the meeting.
#SHOCKCON25 #UVMLarnerMed
Cold stored #platelets win the race! They can be given much faster during trauma resuscitation because they can be kept near point of care. Great work from Macky Neal and team @pittsurgery.bsky.social
#SHOCKCON25 #platelets #trauma #transfusion #EMsky #MedSky 🧪
#SHOCKCON25 #platelets #trauma #transfusion #EMsky #MedSky 🧪
June 2, 2025 at 3:41 PM
Cold stored #platelets win the race! They can be given much faster during trauma resuscitation because they can be kept near point of care. Great work from Macky Neal and team @pittsurgery.bsky.social
#SHOCKCON25 #platelets #trauma #transfusion #EMsky #MedSky 🧪
#SHOCKCON25 #platelets #trauma #transfusion #EMsky #MedSky 🧪
“Lab-van” conversion! UVM @uvmlarnermed.bsky.social
mobile lab is bringing science to students in rural schools across #Vermont.
#scicomm #scienceiscool #stem #medsky #UVMLarnerMed #UVMFutureDocs #LarnerResearch #LarnerFaculty
mobile lab is bringing science to students in rural schools across #Vermont.
#scicomm #scienceiscool #stem #medsky #UVMLarnerMed #UVMFutureDocs #LarnerResearch #LarnerFaculty
May 15, 2025 at 12:42 PM
“Lab-van” conversion! UVM @uvmlarnermed.bsky.social
mobile lab is bringing science to students in rural schools across #Vermont.
#scicomm #scienceiscool #stem #medsky #UVMLarnerMed #UVMFutureDocs #LarnerResearch #LarnerFaculty
mobile lab is bringing science to students in rural schools across #Vermont.
#scicomm #scienceiscool #stem #medsky #UVMLarnerMed #UVMFutureDocs #LarnerResearch #LarnerFaculty
Histone levels are increased in the blood in #trauma and #sepsis. We found that blocking the scramblase TMEM16f prevented pro-thrombotic activation of endothelial cell plasma membranes caused by histone exposure. Could this be a therapeutic target?
#ImmunoSky #EMSky #Medsky #Scicomm
4/n
#ImmunoSky #EMSky #Medsky #Scicomm
4/n
May 2, 2025 at 9:29 AM
TMEM16f is also an #ionchannel. Blocking it prevented endothelial cell calcium release produced by histone exposure.
3/n
3/n
May 2, 2025 at 9:23 AM
TMEM16f is also an #ionchannel. Blocking it prevented endothelial cell calcium release produced by histone exposure.
3/n
3/n
Scott’s syndrome is considered a #platelet disease caused by defects in TMEM16f, but knocking this out in platelets does not cause bleeding problems. In contrast, we found that knocking out TMEM16f in #vascular endothelial cells prevents normal #bloodclotting.
2/n
#Immunosky #EMSky #Medsky 🧪
2/n
#Immunosky #EMSky #Medsky 🧪
May 2, 2025 at 9:21 AM
Scott’s syndrome is considered a #platelet disease caused by defects in TMEM16f, but knocking this out in platelets does not cause bleeding problems. In contrast, we found that knocking out TMEM16f in #vascular endothelial cells prevents normal #bloodclotting.
2/n
#Immunosky #EMSky #Medsky 🧪
2/n
#Immunosky #EMSky #Medsky 🧪
University of Vermont @uvmvermont.bsky.social students in the lab, working hard to wrap up their outstanding research work for the end of the term.
#vermont #uvmlarnermed
#premed #medsky #academicsky
#vermont #uvmlarnermed
#premed #medsky #academicsky
April 30, 2025 at 5:04 PM
University of Vermont @uvmvermont.bsky.social students in the lab, working hard to wrap up their outstanding research work for the end of the term.
#vermont #uvmlarnermed
#premed #medsky #academicsky
#vermont #uvmlarnermed
#premed #medsky #academicsky
Abigail Howard, senior in biomedical engineering, presented her work at the @uvmvermont.bsky.social SRC. She used FACS to understand #vascular #endothelial cell inflammatory responses that drive trauma induced coagulopathy. Stay tuned for paper in preparation from this team!
#EMSky #Immunosky
#EMSky #Immunosky
April 28, 2025 at 1:08 PM
Abigail Howard, senior in biomedical engineering, presented her work at the @uvmvermont.bsky.social SRC. She used FACS to understand #vascular #endothelial cell inflammatory responses that drive trauma induced coagulopathy. Stay tuned for paper in preparation from this team!
#EMSky #Immunosky
#EMSky #Immunosky
Happy dogs. No fences, no leashes - just us & the forest!
#Vermont #GreenMountains #Getoutside #BorderCollies #Dogs #DogsofBlueSky
#Vermont #GreenMountains #Getoutside #BorderCollies #Dogs #DogsofBlueSky
April 25, 2025 at 1:39 AM
Happy dogs. No fences, no leashes - just us & the forest!
#Vermont #GreenMountains #Getoutside #BorderCollies #Dogs #DogsofBlueSky
#Vermont #GreenMountains #Getoutside #BorderCollies #Dogs #DogsofBlueSky
Headline news in our local paper - “Stink Bombs Shut Down Library” - it happened twice in recent weeks, and those naughty schoolchildren are in big trouble!
#Vermont #rural #smalltown #stinkbomb #library
#Vermont #rural #smalltown #stinkbomb #library
March 28, 2025 at 9:19 AM
Headline news in our local paper - “Stink Bombs Shut Down Library” - it happened twice in recent weeks, and those naughty schoolchildren are in big trouble!
#Vermont #rural #smalltown #stinkbomb #library
#Vermont #rural #smalltown #stinkbomb #library
How do endothelial cells in #liver become leaky, while those in #brain tissue form an impermeable barrier? Because transcriptional regulators drive endothelial cells towards organ-specific specialization.
#endothelium #bloodvessel #ImmunoSky#MedSky 🧪
#endothelium #bloodvessel #ImmunoSky#MedSky 🧪
March 28, 2025 at 1:39 AM
How do endothelial cells in #liver become leaky, while those in #brain tissue form an impermeable barrier? Because transcriptional regulators drive endothelial cells towards organ-specific specialization.
#endothelium #bloodvessel #ImmunoSky#MedSky 🧪
#endothelium #bloodvessel #ImmunoSky#MedSky 🧪
Nature's light show, over Waterbury VT tonight 😍
Different colors appear due to the type of gas particles colliding with solar winds: highly reactive atomic oxygen at higher altitudes creates green and red, nitrogen adds blue and purple. 🧪
#scienceiscool #aurora-borealis #northernlights #vermont
Different colors appear due to the type of gas particles colliding with solar winds: highly reactive atomic oxygen at higher altitudes creates green and red, nitrogen adds blue and purple. 🧪
#scienceiscool #aurora-borealis #northernlights #vermont
March 22, 2025 at 2:28 AM
Nature's light show, over Waterbury VT tonight 😍
Different colors appear due to the type of gas particles colliding with solar winds: highly reactive atomic oxygen at higher altitudes creates green and red, nitrogen adds blue and purple. 🧪
#scienceiscool #aurora-borealis #northernlights #vermont
Different colors appear due to the type of gas particles colliding with solar winds: highly reactive atomic oxygen at higher altitudes creates green and red, nitrogen adds blue and purple. 🧪
#scienceiscool #aurora-borealis #northernlights #vermont