Ary Shalizi
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unsequenced.bsky.social
Ary Shalizi
@unsequenced.bsky.social
Biologist, book nerd, parent, hype skeptic in no particular order.

Phenotypic screening for cell and chemical biology.

Also, random book reviews at link.

unsequenced.life
To be fair, Rodriques IS a scientist (PhD with Ed Boyden at MIT, did solid doctoral work, and was faculty at the Crick before starting Future House), but he is also a True Believer.
December 31, 2025 at 12:16 AM
I’ve been reading a lot of what I can only describe as “biotech evangelism” over the last few years, and I’ve noticed that “theoretically possible” is usually conflated with “practically inevitable,” even by accomplished researchers…
December 30, 2025 at 10:18 PM
It’s that #vibephysics we’ve been hearing so much about.
December 29, 2025 at 4:08 PM
I wouldn’t call the people scooped up by Operation Paperclip “refugees.” It was more “we need to collect them before the Soviets do, war crimes be damned.”
December 29, 2025 at 2:48 PM
OTOH, first to the Moon thanks to importing a bunch of barely reformed Nazis from Pennemunde…
December 29, 2025 at 2:45 PM
DoE has problems of its own…

(It’s intellectually provocative and well researched, but as Henry Farrell puts it, probably best considered as “speculative non-fiction.”)
Against Method The Dawn of Everything: A New History of Humanity, by David Graeber and David Wengrow. New York: Farrar, Straus and Giroux 2021. Pp. 704. $35. ISBN 9780374157357 (paper). | American Jou...
www.journals.uchicago.edu
December 29, 2025 at 5:54 AM
The economist Jeff Sachs would be another example. Definitely not right wing, but super into the lab leak idea.
December 29, 2025 at 2:27 AM
I don’t know, there’s a certain class of centrist who believes intelligence reports are superior to scientific evidence (eg, the former obama national security staffer and author Jaime Metzl), and Stewart is one of those.
December 29, 2025 at 2:12 AM
Know the differences between the various tools, they just find “AI” a useful general label.
December 29, 2025 at 2:01 AM
And unfortunately ARE referred to as AI by practitioners using them. I am a cell/molecular biologist, and have computational biologist colleagues who refer to all kinds of AI tools in exactly the kind of undifferentiated way critics find so problematic. These are sophisticated professionals who
December 29, 2025 at 2:01 AM
Ok, but what about systems that propose de novo proteins, a la David Baker’s work? That is also considered generative AI, and a class of language model. Or the use of LLMs for annotating large sequencing datasets, often done with tools like GPT-4? Even the “bad” tools have narrow use cases,
December 29, 2025 at 2:01 AM
Had to stop listening to him once he went full lab leak…
December 28, 2025 at 9:17 PM
Oh, and @annaleen.bsky.social and @charliejane.bsky.social have a great podcast about the intersection of pop culture and tech, but you’re probably aware of that already.
December 28, 2025 at 4:14 PM
I think @adambecker.bsky.social does a great job of exploring the cultural influences on the same iteration of Silicon Valley that Daub discusses, and if Disney was an influence, I don’t think any of the tech titans are going to admit to that…
December 28, 2025 at 4:08 PM
Which Silicon Valley? The pre-internet one of semiconductor manufacturing, or the post-internet one of “there’s an app for that” that Daub is critiquing? Aren’t Silicon Valley and EPCOT/Imagineering coming out of the same modernist aesthetic of the mid-20th century?
December 28, 2025 at 4:08 PM
What kind of monster uses marble armrests?
December 27, 2025 at 4:39 PM
Going for “If we don’t hang together, we all hang separately” energy, but didn’t workshop it ahead of time.
December 27, 2025 at 3:33 AM