Very neat video, and equally neat housekeeping :)

👍

Is there any way, any way at all, that this can be followed remotely? (jk, but if you have a link...)

Great to see this long-form version of your ICLR 2024 work finally out!

Thanks, that makes a lot of sense!

(I.e., each antitoxin mutant is evaluated by making a single-row concatenated MSA with the fixed toxin?)

Small question about this point: here, what input MSA(s) did you use? I'm guessing it was concatenated MSAs with just one row?

One could (modulo depth considerations) use the total/mean MSA perplexity of the concatenated MSAs under MSA Pairformer. The pairing with lowest MSA perplexity should be favoured?

*for all proteins (regardless of taxon or encoding location)

Ah-ha, thanks for the clarification! I am mostly wondering how much of this was unexpected and, relatedly, whether you have decided to turn this pairing mode on for all taxa (and why).