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ucsfstemcell.bsky.social
UCSF Broad Stem Cell Center
@ucsfstemcell.bsky.social
870 followers 370 following 35 posts
Discovering the inner workings of stem cells, engineering treatments using genome editing tools, and healing patients by developing life-saving therapies.
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ucsfstemcell.bsky.social
Kyle Cromer's team published collaborative work with Stanford in @bloodadvances.bsky.social using CRISPR tools to create a mouse model of a rare juvenile leukemia. Congrats to Roshani Sinha, Devesh Sharma, & Benjamin Lesch for co-authoring this publication. More: ashpublications.org/bloodadvance...
November 12, 2025 at 4:15 PM
ucsfstemcell.bsky.social
Join us today, 10/16, for Getting to Patients! Dr. Claire Clelland will share “Developing CRISPR gene therapy for C9orf72 FTD/ALS: the path ahead to clinic” with Special Guests and perspectives from a family with the C9orf72 gene tiny.ucsf.edu/14kshU @ucsfsurgery.bsky.social
October 16, 2025 at 6:21 PM
ucsfstemcell.bsky.social
Congrats to Kyle Cromer, PhD, on receiving an NIH Director’s New Innovator Award! Dr. Cromer is working on better treatments for sickle cell disease by trying to help the bone marrow produce more healthy red blood cells. 🧬 #UCSFProud www.ucsf.edu/news/2025/10...
October 10, 2025 at 7:36 PM
ucsfstemcell.bsky.social
For #StemCellAwarenessDay, a look at a human neuron grown from stem cells, captured by Dr. Yonatan Perez, a Kriegstein Lab postdoc alum. This work could inform therapies for neurological disorders and brain regeneration.
October 8, 2025 at 2:24 PM
ucsfstemcell.bsky.social
Congratulations to our Broad Center members (Bruce Conklin, Tippi MacKenzie, Jingjing Li, Benoit Bruneau, and Holger Willenbring) and colleagues on their newly awarded CIRM Discovery (DISC0) grants!
September 26, 2025 at 7:42 PM
ucsfstemcell.bsky.social
From cloudy mornings to golden sunsets—the UCSF Broad Stem Cell Center always has a view worth sharing. 🌿☀️ Thanks to Lael and Cassie from the IRM Admin Team for these shots! #UCSF #Dolby #KarlTheFog #OfficeViews #CampusViews #GoldenHour
September 24, 2025 at 7:58 PM
ucsfstemcell.bsky.social
Congrats to Lilian Gomes de Oliveira, PhD, who joins the 2025 class of Pew scholars and fellows! As a Pew Latin American Fellow, Lilian will explore how the Zika virus disrupts cerebral cortex development during the second trimester of pregnancy. Learn More: www.pew.org/en/about/new...
The Pew Charitable Trusts today announced the 2025 class of the Pew Latin American Fellows Program in the Biomedical Sciences. The 10 postdoctoral fellows from five Latin American countries—Argentina, Bolivia, Brazil, Chile, and Mexico—will receive two years of funding to conduct research in laboratories throughout the United States. They will work under the mentorship of prominent biomedical scientists, including alumni from the Latin American fellows program and the Pew Scholars Program in the Biomedical Sciences. “Scientific exchange and collaboration foster new discoveries that help advance human health for all,” said Donna Frisby-Greenwood, Pew’s senior vice president for Philadelphia and scientific advancement. “Pew is proud to support this outstanding group of young researchers, whose pursuits will help pave the way to biomedicine’s future.” Fellows who choose to return to Latin America to launch their own research labs will receive additional funding from Pew. Nearly 70% of program participants have taken this path, which has helped cultivate a robust biomedical research community in Latin America. Scientists in the 2025 class are exploring a range of research topics, including examining how brain tumors evolve to resist therapy, the ways in which immune cells reduce chronic pain during pregnancy, and how the nervous system rebuilds after injury.
August 12, 2025 at 8:57 PM
ucsfstemcell.bsky.social
New from the Cromer Lab detailing methods for achieving high-efficiency CRISPR-based genome editing in primary hematopoietic stem and progenitor cells (HSPCs). Discover more @cp-starprotocols.bsky.social | star-protocols.cell.com/protocols/4394
What’s the story? The protocol provides step-by-step methods to efficiently and safely edit the genome in human hematopoietic stem cells (HSCs) using the CRISPR/AAV editing platform, from preparing the repair template, maintaining the HSCs, and evaluating the editing outcomes. What did they learn? The researchers demonstrated that using their CRISPR‑Cas9 plus AAV protocol on human HSCs leads to highly efficient genome editing and robust production of functional erythroid cells in vitro. What’s the impact? The piece, published in STAR Protocols journal, provides a reliable, efficient way to edit human HSCs while keeping them healthy, paving the way for developing new genome editing therapies for blood disorders.
August 12, 2025 at 7:10 PM
ucsfstemcell.bsky.social
Congratulations, Jaela Caston and @elizabethcrouch.bsky.social!! We’re #UCSFProud to celebrate you as 2025 Gilliam Fellow & Advisor 🎉 @ucsanfrancisco.bsky.social

www.hhmi.org/programs/gil...
The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments. Through this program, HHMI supports both graduate students and their faculty thesis advisors. Fellows receive up to three years of PhD dissertation support alongside numerous opportunities to connect with peers, program alumni, and HHMI scientists at every career stage. Both students and advisors benefit from tailored professional development programming and become part of HHMI’s vibrant scientific community.
August 8, 2025 at 7:06 PM
ucsfstemcell.bsky.social
🧬 The gene therapy landscape for sickle cell is evolving—join the UCSF Sickle Cell Center of Excellence for a powerful virtual town hall with Dr. Mark Walters, an expert in sickle cell and cell/gene therapy. This session is perfect for patients, caregivers, healthcare professionals, and advocates.
August 4, 2025 at 8:18 PM
ucsfstemcell.bsky.social
Today! Join us for our Getting to Patients seminar. Dr. Matthay will share “Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells for ARDS: Pre-Clinical and Clinical Data” with patient perspective and discussion moderated by Dr. Julia Brown tiny.ucsf.edu/StromalCells... @ucsfsurgery.bsky.social
May 29, 2025 at 8:52 PM
ucsfstemcell.bsky.social
Hear how gene therapies can address serious genetic diseases before birth. Dr. Tippi MacKenzie will deliver a George Stamatoyannopoulos Memorial Lecture at the @asgct.bsky.social Annual Meeting on May 15. #ASGCT2025 #GeneTherapy #PrenatalResearch #raredisease
Slide for AGC 28th Annual Meeting keynote lecture by Tippi C. MacKenzie, MD, titled "Prenatal Gene Therapies for Severe, Early-Onset Genetic Diseases," scheduled for May 15.
May 14, 2025 at 1:44 PM
ucsfstemcell.bsky.social
Join us for Getting to Patients on Thurs, 3/20, in HSW-300! Drs. Peter Stock & Julie Sneddon share “Beta Cell Replacement Therapies for the Treatment of Diabetes Mellitus” with patient perspective and discussion with @juliaehbrown.bsky.social tiny.ucsf.edu/Diabetes
March 13, 2025 at 4:06 PM
ucsfstemcell.bsky.social
Mercedes Paredes + a team of researchers from @ucsanfrancisco.bsky.social @ihgatucsf.bsky.social + @ucdavis.bsky.social received a $6.25M grant from the California Institute for Regenerative Medicine to explore a new approach for treating CNS-associated microdeletion syndromes tiny.ucsf.edu/WrkHzw
February 4, 2025 at 5:48 PM
ucsfstemcell.bsky.social
A team from UCSF, UCLA, and UC Santa Cruz has secured a $10.3M California Institute for Regenerative Medicine funding grant to develop new stem cell-based treatments for neuropsychiatric disorders. #Neuroscience #StemCells #CIRMReMIND

🔗 Read more: stemcell.ucsf.edu/news/scienti...
January 31, 2025 at 10:17 PM
ucsfstemcell.bsky.social
Latest study from Cromer Lab! The team, w/collaborators @stanfordmedicine.bsky.social, @emorydeptofmed.bsky.social, @ucsfsurgery.bsky.social show for the first time that gene therapy/genome editing can restore hemoglobin production in α-thalassemia major cells: www.sciencedirect.com/science/arti...
Diagram of gene therapy for α-thalassemia major: Cas9/AAV edits patient-derived HSPCs, producing corrected erythroid cells to restore hemoglobin production and improve α-globin levels.
January 7, 2025 at 8:08 PM
ucsfstemcell.bsky.social
Join our UCSF Broad Stem Cell team! Faculty position (#JPF05360) for candidates with a background in Developmental & Stem Cell Biology or Regenerative Medicine, particularly genome editing or hematopoietic stem cell biology. Check out the job description and apply now ➡️ aprecruit.ucsf.edu/JPF05360
Hiring announcement from UCSF Broad Stem Cell Center for a faculty position in biology or regenerative medicine. Includes application link.
November 15, 2024 at 3:59 PM