I am very sad to hear about Zara’s passing. Beautifully said, Willow.

Way to go, Lauren and lab 💪🎉.

Functionally, these molecular changes translate into remodeled neuronal architecture:

➡️ Enhanced dendritic arborization
➡️ Synapse formation

This highlights a mechanism by which receptor trafficking can contribute to neuronal plasticity. Intracellular GPCRs for the win! 4/4

We show that internalized receptors are not silent passengers: they remain active on endosomes and drive extensive neuronal gene expression rewiring through CREB-dependent transcription and mTOR-dependent translation. 3/4

GPCRs are classically known for their signaling at the plasma membrane. But what happens after they internalize into endosomes? We asked how endocytosis of the β2-adrenergic receptor influences neuronal function. 2/4

Congrats!

Excellent news! Congratulations, Gavin.

We used ribosome profiling to uncover a vast translational regulatory program controlled by a prototypical GPCR and second messenger. This is dependent on receptor compartmentalization and driven by spatially confined GPCR-dependent activation of #mTOR.

@bookmarkth.is; great question, I bet many of us I would love to know

Thank you, Karen!