Thomas Stocker
@tsto3616.bsky.social
A fairly new PhD student with a broader focus on all canine hookworms, but specifically the genomics and transcriptomics of Uncinaria stenocephala. U. stenocephala is frequently overlooked despite being ubiquitous in temperate regions!
🧪 further work is coming on a previously unsequenced parasite of dogs, Uncinaria stenocephala… watch this space!
July 24, 2025 at 9:18 AM
🧪 further work is coming on a previously unsequenced parasite of dogs, Uncinaria stenocephala… watch this space!
We need screening now before resistance is at outbreak levels in human medicine, much like it is in canine medicine. #health #hookworms #medicine #NTD #science
July 24, 2025 at 6:28 AM
We need screening now before resistance is at outbreak levels in human medicine, much like it is in canine medicine. #health #hookworms #medicine #NTD #science
A past study of ours compared the genetic frequency of resistance in mixed samples to that of clinical resistance (inability to suppress development) and we found that there’s a threshold of ~ 75% resistant mutants required to induce clinical resistance 🧵 www.sciencedirect.com/science/arti...
Widespread occurrence of benzimidazole resistance single nucleotide polymorphisms in the canine hookworm, Ancylostoma caninum, in Australia
Canine hookworm (Ancylostoma caninum), a gastrointestinal nematode of domestic dogs, principally infects the small intestine of dogs and has the poten…
www.sciencedirect.com
July 24, 2025 at 6:28 AM
A past study of ours compared the genetic frequency of resistance in mixed samples to that of clinical resistance (inability to suppress development) and we found that there’s a threshold of ~ 75% resistant mutants required to induce clinical resistance 🧵 www.sciencedirect.com/science/arti...
If there’s any resemblance to the outbreaks of resistance in Australia, Canada, America and India for canine hooks then it’s likely that resistance will be widespread in human hooks in the absence of drug-stewardship! 🧵
July 24, 2025 at 6:28 AM
If there’s any resemblance to the outbreaks of resistance in Australia, Canada, America and India for canine hooks then it’s likely that resistance will be widespread in human hooks in the absence of drug-stewardship! 🧵
It means the widespread mutations Q134Y, F167Y, E198A and F200L causative to resistance in dog hooks that are already documented in human hooks are now known to be causal to benzimidazole resistance. 🧵
July 24, 2025 at 6:28 AM
It means the widespread mutations Q134Y, F167Y, E198A and F200L causative to resistance in dog hooks that are already documented in human hooks are now known to be causal to benzimidazole resistance. 🧵