tspisak.bsky.social
@tspisak.bsky.social
Pinned
As many of you know, I’ve been fascinated by brain attractor dynamics lately.

Thrilled to share a new preprint on their link to orthogonal neural representations, co-authored with Karl Friston:
arxiv.org/abs/2505.22749
- with implications for both neuroscience & AI!

First in a series - stay tuned!
Self-orthogonalizing attractor neural networks emerging from the free energy principle
Attractor dynamics are a hallmark of many complex systems, including the brain. Understanding how such self-organizing dynamics emerge from first principles is crucial for advancing our understanding ...
arxiv.org
Replicability of BWAS with functional and structural MRI has been hotly debated.
But what about DWI?

Our new paper - first authored by @rkotikalapudi.bsky.social - shows that multivariate DWI models of trait-like phenotypes can be replicable, even with moderate sample sizes.

🔗 Link in comment!
November 7, 2025 at 9:00 AM
Reposted
Serious concerns about a new cortical biomarker for pain sensitivity

jamanetwork.com/journals/jam...

We (with @tspisak.bsky.social, @christianbuchel.bsky.social) published a commentary on Chowdhury, Bi et al. (2025, JAMA Neurology) raising serious concerns about their reported results.

👇 1/13
Concern About Predictive Performance of a Pain Sensitivity Biomarker
To the Editor Chowdhury et al1 evaluated a biomarker for pain sensitivity, combining peak alpha frequency and corticomotor excitability. The authors report outstanding performance (validation set area...
jamanetwork.com
July 22, 2025 at 3:24 PM
As many of you know, I’ve been fascinated by brain attractor dynamics lately.

Thrilled to share a new preprint on their link to orthogonal neural representations, co-authored with Karl Friston:
arxiv.org/abs/2505.22749
- with implications for both neuroscience & AI!

First in a series - stay tuned!
Self-orthogonalizing attractor neural networks emerging from the free energy principle
Attractor dynamics are a hallmark of many complex systems, including the brain. Understanding how such self-organizing dynamics emerge from first principles is crucial for advancing our understanding ...
arxiv.org
May 30, 2025 at 7:14 AM
🚨 New paper out in GigaScience!
To avoid common pitfalls in multivariate modeling: combine external validation with pre-registration — freeze your model before testing.

For the pros: decide on the fly when to stop training!
First-authored by the brilliant @ggallitto.bsky.social
A new approach for transparent reporting of prospective predictive modeling studies involving preregistration of machine learning models.

External validation of machine learning models—registered models and adaptive sample splitting doi.org/10.1093/giga...
External validation of machine learning models—registered models and adaptive sample splitting
AbstractBackground. Multivariate predictive models play a crucial role in enhancing our understanding of complex biological systems and in developing innov
doi.org
May 28, 2025 at 8:44 PM