It also induced a unique, intermittent non-wake/non-sleep “State-C,” marked by behavioral arrest and reduced γ-power, without major δ changes.

Together, these findings suggest that associative spine enlargement is critical for sustaining cortical processing and wakefulness.

Interestingly, broad induction of SynC in the frontoparietal cortex caused acute deficits in goal-directed behaviors (e.g., laser-dot chasing).
The firing rates of cortical neurons were largely unchanged, but pairwise correlations between neurons decreased.

Excited to share our new preprint:
Blockade of associative spine enlargement impairs awake cortical function
biorxiv.org/content/10.1...