In this work, we present a novel radiochemical separation method for isolating radiocopper from zinc targets, in particular optimized for use in compact cyclotron systems for 67 Cu production from 70 ...

Antimony-119 (119Sb, t1/2 = 38.19 h) is an Auger electron emitting radionuclide of interest for radiopharmaceutical therapy. It can be directly produced by proton bombardment of tin-119 using low...

Increasing interest in 67Cu for targeted radionuclide therapy necessitates development of robust and validated analytical methods to ensure compliance with regulatory standards for clinical translatio...

Terbium-155 (t1/2 = 5.32 days) is one of four medically relevant radioisotopes of terbium. It is of interest to the field as a suitable diagnostic counterpart for therapeutic radiolanthanides, as its decay scheme includes γ-rays that are suitable for single photon emission computed tomography (SPECT) imaging. Additionally, 155Tb has an Auger electron (AE) yield that is viable for AE therapy. There are several direct and indirect production routes that can produce 155Tb. Two possible direct routes include proton irradiation on gadolinium targets via 155Gd(p,n)155Tb and 156Gd(p,2n)155Tb. The 155Gd(p,n)155Tb reaction is accessible at incident proton beam energies of ∼10 MeV, whereas the 156Gd(p,2n)155Tb nuclear reaction requires ∼18 MeV. This study aims to investigate the production of 155Tb from natGd through the natGd(p,x) nuclear reaction, wherein both (p,n) and (p,2n) reactions were leveraged, and the purification using a three-column ion chromatography method. Using this system, recoveries of radioterbium of up to 97% were achieved in addition to high recoveries of the Gd target material, illustrating the suitability of this technique for enriched targets.

Terbium-155 (t1/2 = 5.32 days) is one of four medically relevant radioisotopes of terbium. It is of interest to the field as a suitable diagnostic counterpart for therapeutic radiolanthanides, as its ...

Accurate determination of ultratrace plutonium isotopes (238Pu, 239Pu, 240Pu, and 241Pu) generally requires the utilization of multiple techniques. Among them, alpha spectrometry is the only way to me...

Purpose Despite the clinical evidence of actinium-225 (225Ac)-based targeted alpha therapies (TαT) efficacy, optimized treatment regimens are needed to improve overall clinical response rates and decr...

In this work, a radiochemical method that efficiently separates and detect three radioactive chemical species: radium, thorium, and uranium, along with their respective alpha-emitting isotopes, is pre...

Background Zirconium-89 (89Zr) is a highly valued diagnostic radionuclide for positron emission tomography (PET) due to its long physical half-life of 78.4 h and decay characteristics, being preferred...

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