Trevor Graham
banner
trevorgraham.bsky.social
Trevor Graham
@trevorgraham.bsky.social
Director, Centre for Evolution and Cancer @cec-icr.bsky.social at @icr.ac.uk

Genomics, epigenetics, evolution, mathematical modelling, data science, bowel cancer
Both projects involve lots of collaboration, supervision, mentorship and training (& travel!) across our @evomg-dn.bsky.social network. They mandate motility across the #EU and partner countries too. Consequently I think the studentships will offer exceptionally rich #PhD experiences.
October 14, 2025 at 8:30 PM
The second is about potential fitness costs of cancer drug resistance, and how we might exploit them using approaches like adaptive therapy. (building on our work with @mlockley.bsky.social in ovarian cancer: aacrjournals.org/cancerres/ar...). Description here: www.icr.ac.uk/study-and-ca...
Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
Carboplatin adaptive therapy improves treatment efficacy without increasing daily dose due to reduced fitness of drug-resistant populations, which can be tracked using cfDNA and could direct adaptive ...
aacrjournals.org
October 14, 2025 at 8:26 PM
The first is about developing new approaches to track cancer evolution from cell free DNA (cfDNA - liquid biopsy), and is a collaboration with industry partner nonacus.com Description here: www.icr.ac.uk/study-and-ca...
October 14, 2025 at 8:23 PM
thanks Vijay!
September 13, 2025 at 10:04 AM
Thanks Christian!
September 10, 2025 at 3:49 PM
A nice news and views about the paper too: www.nature.com/articles/d41...

Thank you Pavlo Lutsik @kuleuvenuniversity.bsky.social & Veselin Manojlovic, George Vassiliou @cruk-ci.bsky.social
Epigenetic clues from cancer’s past foretell its future
An innovative method to trace tumour evolution using patterns of fluctuating DNA modifications could be implemented in the clinic to predict cancer progression.
www.nature.com
September 10, 2025 at 3:39 PM
I'm really excited about this work: EVOFLUx tech means we can measure cancer evo at massive scale, even reusing old data. Truly joyful collaboration with brilliant @calumgabbutt.bsky.social Inaki Martin & Marti Duran @idibaps.bsky.social @imperialcollegeldn.bsky.social @qmbci.bsky.social @icr.ac.uk
September 10, 2025 at 3:26 PM
With the wonderful Inaki Martin-Subero & Marti Duran @idibaps.bsky.social we applied the method (called EVOFLUx) to meth data from ~2000 lymphoid cancers, inferring cancer age, initial growth rate & other evo dynamics. This evolutionary history strongly predicted clinical outcome, especially in CLL.
September 10, 2025 at 3:23 PM
Schmidt Fellows: if you're a #compbio #AI postdoc, feel free to drop me a line to discuss ideas and I can help you find host labs in the @icr.ac.uk

Postdocs in the USA who'd like to return to Europe to set up their own thing... these could be for you?

www.imperial.ac.uk/jobs/search-...
Search jobs for external candidates | Jobs | Imperial College London
www.imperial.ac.uk
July 15, 2025 at 8:37 AM