Enrique Martinez
@tremorswift.bsky.social
Movement disorders fellow @ University of Florida 🐊☀️
DM me your tract pictures 🧠 and videos of tremors 🌀
DM me your tract pictures 🧠 and videos of tremors 🌀
About half of patients with normal pressure hydrocephalus and parkinsonism have an abnormal DaT SPECT. But they do not have nigrosomal loss like in PD!
Is their parkinsonism from mechanical disruption rather than neurodegeneration?
Check out this cool study!
www.neurology.org/doi/full/10....
Is their parkinsonism from mechanical disruption rather than neurodegeneration?
Check out this cool study!
www.neurology.org/doi/full/10....
February 15, 2025 at 2:07 AM
About half of patients with normal pressure hydrocephalus and parkinsonism have an abnormal DaT SPECT. But they do not have nigrosomal loss like in PD!
Is their parkinsonism from mechanical disruption rather than neurodegeneration?
Check out this cool study!
www.neurology.org/doi/full/10....
Is their parkinsonism from mechanical disruption rather than neurodegeneration?
Check out this cool study!
www.neurology.org/doi/full/10....
Check out this paper I just dropped on non-motor phenotypes in Parkinson's disease with my bosses
We found that patients with early REM sleep behavior in Parkinson's predicts WORSE non-motor symptoms.
rdcu.be/d7QV2
We found that patients with early REM sleep behavior in Parkinson's predicts WORSE non-motor symptoms.
rdcu.be/d7QV2
January 29, 2025 at 2:45 AM
Check out this paper I just dropped on non-motor phenotypes in Parkinson's disease with my bosses
We found that patients with early REM sleep behavior in Parkinson's predicts WORSE non-motor symptoms.
rdcu.be/d7QV2
We found that patients with early REM sleep behavior in Parkinson's predicts WORSE non-motor symptoms.
rdcu.be/d7QV2
DBS at the GPi and STN works well for dystonia, with most output reaching the Vo nucleus of the thalamus.
Why not target that?
Hashimoto and friends shared 4 cases of focal hand dystonia treated with thalamic DBS, showing most benefit near the Vo—same as for dystonic tremor!
Why not target that?
Hashimoto and friends shared 4 cases of focal hand dystonia treated with thalamic DBS, showing most benefit near the Vo—same as for dystonic tremor!
Effective Target Sites in Thalamic Stimulation for Focal Hand Dystonia
Abstract. Introduction: Functional thalamic surgery is known for alleviating isolated focal hand dystonia; however, the optimal target site in the thalamus is not determined. This study aimed to ident...
tinyurl.com
January 26, 2025 at 2:58 PM
DBS at the GPi and STN works well for dystonia, with most output reaching the Vo nucleus of the thalamus.
Why not target that?
Hashimoto and friends shared 4 cases of focal hand dystonia treated with thalamic DBS, showing most benefit near the Vo—same as for dystonic tremor!
Why not target that?
Hashimoto and friends shared 4 cases of focal hand dystonia treated with thalamic DBS, showing most benefit near the Vo—same as for dystonic tremor!
🔔 New drug for PD-MCI! 🔔
💊 M1 Receptor–Positive Allosteric Modulator.
👥 46 patients | 🕒 6 wks on /6 wksoff
🧷 Safe overall | 🚷 No gait changes
🧠 Cognitive improvement (?)
Could it be real-life significant? Rivastigmine only works in PD dementia—this could be a first!
tinyurl.com/rjxxwbxe
💊 M1 Receptor–Positive Allosteric Modulator.
👥 46 patients | 🕒 6 wks on /6 wksoff
🧷 Safe overall | 🚷 No gait changes
🧠 Cognitive improvement (?)
Could it be real-life significant? Rivastigmine only works in PD dementia—this could be a first!
tinyurl.com/rjxxwbxe
January 20, 2025 at 3:01 AM
🔔 New drug for PD-MCI! 🔔
💊 M1 Receptor–Positive Allosteric Modulator.
👥 46 patients | 🕒 6 wks on /6 wksoff
🧷 Safe overall | 🚷 No gait changes
🧠 Cognitive improvement (?)
Could it be real-life significant? Rivastigmine only works in PD dementia—this could be a first!
tinyurl.com/rjxxwbxe
💊 M1 Receptor–Positive Allosteric Modulator.
👥 46 patients | 🕒 6 wks on /6 wksoff
🧷 Safe overall | 🚷 No gait changes
🧠 Cognitive improvement (?)
Could it be real-life significant? Rivastigmine only works in PD dementia—this could be a first!
tinyurl.com/rjxxwbxe
We love how effective DBS is to treat myoclonus dystonia syndrome.
Patients with a SGCE mutation have one of the B E S T responses.
Pauly M shared the case of KCCN2 mutation who did not improve significantly after GPi-DBS.
Should we test SGCE-negative patients before DBS?
tinyurl.com/msp6t8fa
Patients with a SGCE mutation have one of the B E S T responses.
Pauly M shared the case of KCCN2 mutation who did not improve significantly after GPi-DBS.
Should we test SGCE-negative patients before DBS?
tinyurl.com/msp6t8fa
January 18, 2025 at 5:10 PM
We love how effective DBS is to treat myoclonus dystonia syndrome.
Patients with a SGCE mutation have one of the B E S T responses.
Pauly M shared the case of KCCN2 mutation who did not improve significantly after GPi-DBS.
Should we test SGCE-negative patients before DBS?
tinyurl.com/msp6t8fa
Patients with a SGCE mutation have one of the B E S T responses.
Pauly M shared the case of KCCN2 mutation who did not improve significantly after GPi-DBS.
Should we test SGCE-negative patients before DBS?
tinyurl.com/msp6t8fa