Tony Bai
@tonybai-id.bsky.social
Infectious diseases doctor and researcher at Queen’s University, Kingston, ON, Canada
There is another recent study finding a similar signal that better addresses the confounding issue than our JAMA Network paper by using Ampicillin Sulbactam plus Lansoprazole as a comparison group
www.journalofinfection.com/article/S016...
www.journalofinfection.com/article/S016...
Concomitant use of lansoprazole and ceftriaxone is associated with an increased risk of ventricular arrhythmias and cardiac arrest in a large Japanese hospital database
To determine whether concomitant use of ceftriaxone and oral or intravenous lansoprazole
increases the risk of ventricular arrhythmia and cardiac arrest in the real-world
setting in Japan.
www.journalofinfection.com
February 27, 2025 at 7:53 PM
There is another recent study finding a similar signal that better addresses the confounding issue than our JAMA Network paper by using Ampicillin Sulbactam plus Lansoprazole as a comparison group
www.journalofinfection.com/article/S016...
www.journalofinfection.com/article/S016...
The proposed mechanism is that the combination block the hERG channel, based on this paper:
pubmed.ncbi.nlm.nih.gov/27737742/
pubmed.ncbi.nlm.nih.gov/27737742/
Coupling Data Mining and Laboratory Experiments to Discover Drug Interactions Causing QT Prolongation - PubMed
Coupling data mining and laboratory experiments is an efficient method for identifying QT-DDIs. Combination therapy of ceftriaxone and lansoprazole is associated with increased risk of acquired long Q...
pubmed.ncbi.nlm.nih.gov
February 27, 2025 at 7:48 PM
The proposed mechanism is that the combination block the hERG channel, based on this paper:
pubmed.ncbi.nlm.nih.gov/27737742/
pubmed.ncbi.nlm.nih.gov/27737742/
I usually do 7 days from the last debridement which I regard as definitive source control.
November 26, 2024 at 11:31 AM
I usually do 7 days from the last debridement which I regard as definitive source control.