Tomi Parviainen
@tomppapa.bsky.social
⌬ Doctoral researcher at University of Oulu, Finland ⌬ Organic synthesis and everything that comes along with it ⌬ Currently MedChem, background in materials chemistry ⌬
Excited to share that the second article of my PhD thesis is now out in ACS Chem Biol!
In this study, we identified and developed inhibitors for ARH3 - one of the key enzymes hydrolyzing #ADP-ribosylation in humans.
Huge thanks to everyone involved! ❤️
pubs.acs.org/doi/10.1021/...
In this study, we identified and developed inhibitors for ARH3 - one of the key enzymes hydrolyzing #ADP-ribosylation in humans.
Huge thanks to everyone involved! ❤️
pubs.acs.org/doi/10.1021/...
Discovery and Structural Optimization of 2-Hydrazinopyrimidin-4-one Analogs Inhibiting Human ADP-Ribosylhydrolase ARH3
Poly-ADP-ribosylation at sites of DNA damage, catalyzed by PARP enzymes, activates the DNA damage response, chromatin remodeling, and DNA repair. The modification is reversed by two enzymes in humans:...
pubs.acs.org
October 1, 2025 at 5:57 AM
Excited to share that the second article of my PhD thesis is now out in ACS Chem Biol!
In this study, we identified and developed inhibitors for ARH3 - one of the key enzymes hydrolyzing #ADP-ribosylation in humans.
Huge thanks to everyone involved! ❤️
pubs.acs.org/doi/10.1021/...
In this study, we identified and developed inhibitors for ARH3 - one of the key enzymes hydrolyzing #ADP-ribosylation in humans.
Huge thanks to everyone involved! ❤️
pubs.acs.org/doi/10.1021/...