Tomoki T. Mitani
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tomoki-t-mitani.bsky.social
Tomoki T. Mitani
@tomoki-t-mitani.bsky.social
41 followers 220 following 4 posts
Ph.D candidate, Osaka University, Japan. M.D. Neurologist.
Whole-brain spatial biologist and light-sheet microscope engineer.
My best work: https://www.researchsquare.com/article/rs-5827312/v1
Cellomics: https://www.nature.com/articles/s41592-024-02307-5
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Reposted by Tomoki T. Mitani
tomoki-t-mitani.bsky.social
新しいプレプリントを公開しました！
5,161万細胞からなる世界初の3D全脳単一ニューロンアトラスを構築し、全神経細胞の微小環境を解析しました。その結果、健常老化やアルツハイマー病において保護が手薄な「ミクログリアのセキュリティホール」が存在し、神経細胞の脆弱性を加速する可能性が示唆されました。つまり、ミクログリアの増殖ではなく喪失が神経脱落の先行マーカーになる可能性があります。
今後、publish後に詳しく解説いたします。

詳細はこちら: www.researchsquare.com/article/rs-5...
#Neuroscience #Alzheimers #Aging
Whole-Brain Single-Neuron Atlas Reveals Microglial Security Hole Accelerating Neuronal Vulnerability
Neurodegenerative diseases are characterized by progressive neuronal loss, yet subtle degeneration remains difficult to detect, hindering advancements in early diagnosis and intervention strategies. H...
www.researchsquare.com
February 17, 2025 at 1:15 PM
Reposted by Tomoki T. Mitani
tomoki-t-mitani.bsky.social
My new preprint!
We built a 3D whole-brain neuron atlas (51.61M). 3D cellomics reveals “microglial security holes” in aging/AD, accelerating neuronal vulnerability. Microglial loss, not proliferation, may be an early sign of neuronal loss.
www.researchsquare.com/article/rs-5... #Alzheimers #Aging
Whole-Brain Single-Neuron Atlas Reveals Microglial Security Hole Accelerating Neuronal Vulnerability
Neurodegenerative diseases are characterized by progressive neuronal loss, yet subtle degeneration remains difficult to detect, hindering advancements in early diagnosis and intervention strategies. H...
www.researchsquare.com
February 17, 2025 at 1:35 PM
tomoki-t-mitani.bsky.social
My new preprint!
We built a 3D whole-brain neuron atlas (51.61M). 3D cellomics reveals “microglial security holes” in aging/AD, accelerating neuronal vulnerability. Microglial loss, not proliferation, may be an early sign of neuronal loss.
www.researchsquare.com/article/rs-5... #Alzheimers #Aging
Whole-Brain Single-Neuron Atlas Reveals Microglial Security Hole Accelerating Neuronal Vulnerability
Neurodegenerative diseases are characterized by progressive neuronal loss, yet subtle degeneration remains difficult to detect, hindering advancements in early diagnosis and intervention strategies. H...
www.researchsquare.com
February 17, 2025 at 1:35 PM
tomoki-t-mitani.bsky.social
新しいプレプリントを公開しました！
5,161万細胞からなる世界初の3D全脳単一ニューロンアトラスを構築し、全神経細胞の微小環境を解析しました。その結果、健常老化やアルツハイマー病において保護が手薄な「ミクログリアのセキュリティホール」が存在し、神経細胞の脆弱性を加速する可能性が示唆されました。つまり、ミクログリアの増殖ではなく喪失が神経脱落の先行マーカーになる可能性があります。
今後、publish後に詳しく解説いたします。

詳細はこちら: www.researchsquare.com/article/rs-5...
#Neuroscience #Alzheimers #Aging
Whole-Brain Single-Neuron Atlas Reveals Microglial Security Hole Accelerating Neuronal Vulnerability
Neurodegenerative diseases are characterized by progressive neuronal loss, yet subtle degeneration remains difficult to detect, hindering advancements in early diagnosis and intervention strategies. H...
www.researchsquare.com
February 17, 2025 at 1:15 PM
Reposted by Tomoki T. Mitani
willmacnair.bsky.social
From a skim read looks both interesting and like a lot of work!
prepub-neurodegen.bsky.social #NeuroDegeneration preprints @prepub-neurodegen.bsky.social · Feb 12
Whole-Brain Single-Neuron Atlas Reveals Microglial Security Hole Accelerating Neuronal Vulnerability #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-5827312/latest
February 12, 2025 at 12:10 PM