I think you want to have good control over transport phenomena so that you are close to intrinsic kinetics. Then you can use classical correlations to help with the design of the large scale processes

I believe yes. Depends what you refer to Here. Conditions found on small scale can be scaled to larger throughput reactors

Agreed! That’s why multiple-author papers (for intralab reproducibility), thorough mechanistic studies, and solid follow-up work are so important.

Sometimes, issues come down to hidden variables rather than fabrication—so it's crucial to investigate before assuming the worst!

We published our methodology & are now working on a mechanistic study to explain why the original paper might have lacked crucial details. Interestingly, some retracted follow-ups likely had the right idea but missed these key nuances—we think we can now explain their mistakes!

Great read! We've also struggled with reproducing literature results. One case took us 3 months of poor selectivity & low yields—until a sudden breakthrough! The method was super finicky, where small changes = big impact.