www.cell.com/cell-systems...

CosMx data by @brukerspatial.bsky.social
Second harmonics by Andrew Woehler
Immunofluorescence by @sonjafritzsche.bsky.social and @josenimo.bsky.social in Fabian Coscia lab
STIM for 3D alignment by @preibischs.bsky.social @nukappa.bsky.social et al (coming very soon!)

7/ Many thanks to whole @NR lab, our supporting institutions @mdc-bimsb.bsky.social @mdc-berlin.bsky.social Charité – Universitätsmedizin Berlin, Berlin School of Integrative Oncology and Joachim Herz Stiftung for the support!!

6/ That’s a wrap! The potential of ST to revolutionize clinical practice is huge, but we still have work to do to unlock its full impact. Stay tuned as the field evolves! 🚀

5/ As large-scale clinical studies are urgently needed to link spatial biomarkers with patient outcomes, we discuss key considerations for the design of clinical ST projects from sample preservation and method choice to panel design and power analysis.

4/ Several challenges exist to their swift clincal translation: What is the ‘best’ ST method? How do we turn complex molecular data into meaningful insights for patient care? How do we integrate in clinical routines?

3/ In the clinic, spatial biomarkers and patient-specific molecular mechanisms identified by ST hold great potential to inform patient care and help the discovery of novel drug targets, as showcased in early preclinical studies

2/ With high-resolution ST we can study tissue organization in 2D and 3D virtual tissue blocks, analyzing the organization of cells in multicellular niches and identifying which receptor–ligand interactions orchestrate their function in situ.

1/ High-resolution ST omics work as molecular microscopes, digitalizing gene expression and tissue morphology at subcellular resolution. This enables the interactive exploration of millions of transcripts and their comparison with routine histology and pathologist annotations.

Check our review on the 'Challenges & Opportunities in Clinical Translation of High-Resolution Spatial Transcriptomics (ST)'!!
annualreviews.org/content/jour...

7/ Many thanks to whole @NR lab, our supporting institutions @mdc-bimsb.bsky.social @mdc-berlin.bsky.social Charité – Universitätsmedizin Berlin, Berlin School of Integrative Oncology and Joachim Herz Stiftung for the support!!

6/ That’s a wrap! The potential of ST to revolutionize clinical practice is huge, but we still have work to do to unlock its full impact. Stay tuned as the field evolves! 🚀

5/ As large-scale clinical studies are urgently needed to link spatial biomarkers with patient outcomes, we discuss key considerations for the design of clinical ST projects from sample preservation and method choice to panel design and power analysis.

4/ Several challenges exist to their swift clincal translation: What is the ‘best’ ST method? How do we turn complex molecular data into meaningful insights for patient care? How do we integrate in clinical routines?

3/ In the clinic, spatial biomarkers and patient-specific molecular mechanisms identified by ST hold great potential to inform patient care and help the discovery of novel drug targets, as showcased in early preclinical studies

2/ With high-resolution ST we can study tissue organization in 2D and 3D virtual tissue blocks, analyzing the organization of cells in multicellular niches and identifying which receptor–ligand interactions orchestrate their function in situ.

1/ High-resolution ST omics work as molecular microscopes, digitalizing gene expression and tissue morphology at subcellular resolution. This enables the interactive exploration of millions of transcripts and their comparison with routine histology and pathologist annotations.

Check our review on the 'Challenges & Opportunities in Clinical Translation of High-Resolution Spatial Transcriptomics (ST)'!!
annualreviews.org/content/jour...