I don't believe that is the consensus. Novel folds can be well predicted if there is strong support from evolutionary information.

I guess any holo structure template implicitly biases the model towards a known ligand-binding site. It would be interesting to know the ceiling of what can be achieved with this implicit information by providing the native ligand holo structure (kind of cross-docking vs re-docking).

When using the ground-truth template AF3 did not achieve perfect fidelity or the template issue only affected a subset of systems?