Tin Nguyen
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tinvtnguyen.bsky.social
Tin Nguyen
@tinvtnguyen.bsky.social
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Grad Student-Waser group, EPFL.
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Reposted by Tin Nguyen
natchem.nature.com
Take a look at the associated News & Views from Jerome Waser @lcsolab.bsky.social and Tin V. T. Nguyen @tinvtnguyen.bsky.social :

www.nature.com/articles/s41...
#chemsky
Photomediated aliphatic C–H functionalization - Nature Chemistry
The C–H functionalization of inert alkanes has long been one of the most challenging reactions in organic synthesis. Now, the use of hypervalent iodine reagents has enabled the diverse functionalizati...
www.nature.com
February 25, 2025 at 10:09 AM
Reposted by Tin Nguyen
lcsolab.bsky.social
Late Christmas gift from @tinvtnguyen.bsky.social and Trinh with photomediated chlorinations of C-H, C-C and C=C bond using the venerable Willgerodt reagent now as preprint on @chemrxiv.bsky.social in collaboration with Thanh at AstraZeneca
chemrxiv.org/engage/chemr...
Csp3-Cl bonds are essential as diversification handles in organic synthesis and are found in many natural products and bioactive molecules. In this work, we introduce a general protocol for the selective chlorination of aryl cyclopropanes, olefins, and activated C-H bonds using the direct photoexcitation of Willgerodt-type reagents to generate chlorine radicals. Preliminary results on an iodine(I/III) catalytic process starting from abundant chloride salts are also presented. Furthermore, a one-pot protocol has been developed for the telescoped functionalization of benzylic chlorides with C, N, O, and S nucleophiles. Especially, this approach provides a platform to access 1,1-diaryl motifs, which are important building blocks for the synthesis of pharmacophores.
December 27, 2024 at 10:52 AM