Finally, we provide a suite of tools that allow users users to convert PDB into ProFlex, search for proteins with similar flexibility patterns in structural databases, and compare ProFlex-encoded protein sequences with each other.

We analysed 15 major capsid protein sequences from Tevenvirinae phages using sequence, structutal and ProFlex comparisons and demonstrated that all tested approaches detect the underlying phylogenetic relationship and provide complementary information about the proteins.

Together with my very good friend and brilliant colleague Damian Magill we developed ProFlex, a protein “alphabet” that turns protein flexibility patterns into an easy-to-compare sequences.

Superb news to kick off the week! 🎉 Our new paper is out today in
@natcomms.nature.com
𝗣𝗿𝗼𝗙𝗹𝗲𝘅 𝗮𝘀 𝗮 𝗹𝗶𝗻𝗴𝘂𝗶𝘀𝘁𝗶𝗰 𝗯𝗿𝗶𝗱𝗴𝗲 𝗳𝗼𝗿 𝗱𝗲𝗰𝗼𝗱𝗶𝗻𝗴 𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝗶𝗻 𝗻𝗼𝗿𝗺𝗮𝗹 𝗺𝗼𝗱𝗲 𝗮𝗻𝗮𝗹𝘆𝘀𝗶𝘀

Thanks to #AI enhanced TEM, we can now see previously missed details of #phage morphology

Extremely proud of Akash Shambharkar, who successfully defended his PhD thesis investigating #phage based approaches against CAUTIs! It was a pleasure supervising Akash with Brendan Gilmore.
Many thanks to Brian Jones and Matthew Wylie for examining, and to Sheiliza Carmali for chairing the viva!

Delighted to represent our lab together with our PhD student Shauna at the NI Science Festival 2025 (@niscifest.bsky.social) and to talk about the exciting bacteriophage research we are conducting at the QUB School of Pharmacy (@qubelfastofficial.bsky.social !

#NISF25 #phage

It's Phriday! Huge thanks to our student Maria for the #phage cake - it was as delicious as it was cool looking!