Temurkhan Ayupov
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timayupov.bsky.social
Temurkhan Ayupov
@timayupov.bsky.social
18 followers 25 following 0 posts
PhD candidate, IOB
https://www.linkedin.com/in/temurkhan-ayupov
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Reposted by Temurkhan Ayupov
gek0s.bsky.social
Gene editing of single, targeted neurons in vivo is now feasible. We are proud to present our preprint for highly efficient single-cell electroporation using RNA. With @alex-fratzl.bsky.social, @munzlab.bsky.social, Botond Roska @iobswiss.bsky.social
#neuroskyence
www.biorxiv.org/content/10.1...
In vivo single-cell gene editing using RNA electroporation reveals sequential adaptation of cortical neurons to excitatory-inhibitory imbalance
The balance between excitatory and inhibitory neurotransmission is fundamental for normal brain function, yet the adaptation of individual neurons to disrupted excitatory-inhibitory balance is not wel...
www.biorxiv.org
September 15, 2025 at 9:19 AM
Reposted by Temurkhan Ayupov
gek0s.bsky.social
Single-cell electroporation is performed via patch pipette and under 2-photon visual guidance in vivo. A short voltage pulse train is applied through the pipette to deliver RNA molecules into a targeted cell. The video below shows this process in cortical neurons expressing GCaMP6s.
September 15, 2025 at 9:19 AM
Reposted by Temurkhan Ayupov
iobswiss.bsky.social
🧬👁️Discover how research and patient care come together in the latest Novartis Live magazine — with stories from the labs and clinics shaping the future of vision.

🔗 bit.ly/4km6XZ0

#IOB #VisionScience #TranslationalResearch #Basel #Ophthalmology #AcademicSky #Novartis
May 13, 2025 at 3:56 PM
Reposted by Temurkhan Ayupov
tdalmay.bsky.social
How do different sensory signals combine in the computation of cognitive maps? I’m thrilled to share our new preprint, in which we investigate this question in the context of the head-direction system:
www.biorxiv.org/content/10.1...
Joint visual-vestibular computation of head direction and reflexive eye movement
Several cognitive maps have been identified, but what sensory signals drive them and how these are combined are not well understood. One such map, the head-direction representation, is believed to be ...
www.biorxiv.org
February 12, 2025 at 6:42 AM
Reposted by Temurkhan Ayupov
iobswiss.bsky.social
✨Thrilled about our new publication in Nature Medicine! We are excited to offer a potential new avenue for treating Stargardt disease!
Read the paper here: nature.com/articles/s41...
Watch the video: iob.ch/fileadmin/ge...
Press release here: iob.ch/news-view-al...

© 2025 IOB
January 8, 2025 at 7:40 PM
Reposted by Temurkhan Ayupov
iobswiss.bsky.social
We are pleased to share that RhyGaze, IOB's first spin-off, has secured Series A funding with an USD 86 million investment to advance vision restoration therapy.

Read more: iob.ch/news-view-al...

#Biotech #Basel #Innovation #LifeSciences #GeneTherapy #Ophthalmology #RhyGaze #BioTechHub
January 10, 2025 at 2:26 PM