Emmanuel Crespo
theglowup.bsky.social
Emmanuel Crespo
@theglowup.bsky.social
molecular engineer & neuroscientist | @NIH F99 Fellow | he/él | another day, another slay | 🏳️‍🌈🧠
Reposted by Emmanuel Crespo
There was this Tsai/Yuste/Shepard paper that meister famously eviscerated. markusmeister.com/2018/03/20/d... It seems that the authors never retracted the paper (or does ieee not mark retractions)? If not, does anyone know why not? @retractionwatch.com
Death of the sampling theorem?
tl;dr: A team from Columbia University led by Ken Shepard and Rafa Yuste claims to beat the 100 year old Sampling Theorem [1,2]. Apparently anti-aliasing filters are superfluous now because one can…
markusmeister.com
December 16, 2024 at 8:11 PM
Me: confident in surgery. Mouse brain, three weeks later: ‘Sure, bud’. 😊🧠🥲
Mouse stereotactic surgery never gets old: you level a tiny irregular skull, go by coordinates based on eyeballed reference points, deliver microdrops of virus following protocolised superstition and whoom, three weeks later, the exact subregion you aimed for lights up (well, sometimes) ✨🧠🧪
November 27, 2024 at 10:26 PM
Reposted by Emmanuel Crespo
Mouse stereotactic surgery never gets old: you level a tiny irregular skull, go by coordinates based on eyeballed reference points, deliver microdrops of virus following protocolised superstition and whoom, three weeks later, the exact subregion you aimed for lights up (well, sometimes) ✨🧠🧪
November 27, 2024 at 10:15 PM
Reposted by Emmanuel Crespo
This shows that we need to apply averages carefully because they mean different things in different experimental contexts. In other words - THINK BEFORE YOUR AVERAGE! And feel welcome to use our test to help you do that. ;)
journals.plos.org/ploscompbiol...
What does the mean mean? A simple test for neuroscience
Author summary Neuronal activity is highly dynamic—our brain never responds to the same situation in exactly the same way. How do we extract information from such dynamic signals? The classical answer...
journals.plos.org
November 26, 2024 at 2:06 PM
Reposted by Emmanuel Crespo
I usually focus on neurons that fire crazy fast, but I like neurons that burst, too!!
November 23, 2024 at 8:03 PM
Reposted by Emmanuel Crespo
Happy #FluorescentFriday

Here is a cerebral organoid expressing 5-HT2A receptors (red) along its outer surface. They seem to be a different set of cells than the CTIP2 positive deep layer neurons (magenta). There seems to be some believable 5-HT2C (green) signal basal to the rosettes too 🔬 #sciart
November 22, 2024 at 6:26 PM
Reposted by Emmanuel Crespo
Felt a little extra today when preparing a spike sorting lecture and put together these illustrations, I could not find anything similar for single electrodes! 🧪🧠⚡

#neuroskyence #SciArt
November 13, 2024 at 12:55 PM
Reposted by Emmanuel Crespo
If you are interested in neural manifolds, dimensionality, brain states, and/or top-down modulation you are gonna like this one! 🧠🙈💫🧪

"Neural manifolds in V1 change with top-down signals from V4 targeting the foveal region" doi.org/10.1016/j.ce...

Also enjoy this animation :) #SciArt #neuroskyence
November 20, 2024 at 10:52 AM
Reposted by Emmanuel Crespo
A paper about our next generation data acquisition system, ONIX, was just published: www.nature.com/articles/s41...
ONIX: a unified open-source platform for multimodal neural recording and perturbation during naturalistic behavior - Nature Methods
ONIX is a data acquisition system for recording freely behaving mice. It can accommodate a variety of recording technologies, while maintaining minimal impact on animal behavior.
www.nature.com
November 11, 2024 at 5:19 PM