Damon May
@the-dee-em.bsky.social
Computational biology (currently immunology, T cells). Roller derby support (I ref and wrote JamStats (http://jamstats.net). D&D.
Make "Disappear" Intransitive Again
April 23, 2025 at 4:45 PM
Make "Disappear" Intransitive Again
The recent "Mal-ID" paper in Science diagnoses diseases from immune repertoires. But a powerful model like Mal-ID can learn differences between groups of immune repertoires that are unrelated to the diseases of interest. We explore these pitfalls in our eLetter response.
Disease diagnostics using machine learning of B cell and T cell receptor sequences
Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system’s own record of antigen ...
www.science.org
March 19, 2025 at 10:35 PM
The recent "Mal-ID" paper in Science diagnoses diseases from immune repertoires. But a powerful model like Mal-ID can learn differences between groups of immune repertoires that are unrelated to the diseases of interest. We explore these pitfalls in our eLetter response.
The Canadian "elbows up" thing is genuine and awesome... and because I'm not a hockey fan it just makes me think of the bonkers fight choreography in _Divergent_.
March 13, 2025 at 4:37 PM
The Canadian "elbows up" thing is genuine and awesome... and because I'm not a hockey fan it just makes me think of the bonkers fight choreography in _Divergent_.
There were a lot of inspiring words at the Seattle Stand Up for Science rally today, but the real inspiration was the energy in the crowd! American science won't just lie down and be destroyed. Stand up, fight back!
standupforscience2025.org
standupforscience2025.org
March 8, 2025 at 1:07 AM
There were a lot of inspiring words at the Seattle Stand Up for Science rally today, but the real inspiration was the energy in the crowd! American science won't just lie down and be destroyed. Stand up, fight back!
standupforscience2025.org
standupforscience2025.org
In her weekly email, my kid's principal referred to the school musical, Hadestown, as "set in a world not too different from our own".
Yep, that's 2025 for you.
Yep, that's 2025 for you.
March 8, 2025 at 12:43 AM
In her weekly email, my kid's principal referred to the school musical, Hadestown, as "set in a world not too different from our own".
Yep, that's 2025 for you.
Yep, that's 2025 for you.
Reposted by Damon May
They’re firing NIH scientists and replacing them with people with this level of crappy chart-making?
Sounds like the DOGE kids would benefit from going through the NIH postbac program. 🧪
Sounds like the DOGE kids would benefit from going through the NIH postbac program. 🧪
not sure what's worse about the DOGE site: unsecured databases, leaking of classified information, or these chart crimes
February 17, 2025 at 1:32 AM
They’re firing NIH scientists and replacing them with people with this level of crappy chart-making?
Sounds like the DOGE kids would benefit from going through the NIH postbac program. 🧪
Sounds like the DOGE kids would benefit from going through the NIH postbac program. 🧪
American science is under full-on assault. I'm an American scientist. I don't like being assaulted. What can I do? Anyone got ideas?
NIH cuts billions of dollars in biomedical funding, effective immediately
The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.
www.washingtonpost.com
February 8, 2025 at 6:35 PM
American science is under full-on assault. I'm an American scientist. I don't like being assaulted. What can I do? Anyone got ideas?
Postdocs aren't getting paychecks, because Trump.
Postdocs are well-educated, but by and large they're *not* rich people. Pulling the rug out from under them like this hurts them badly, and it cripples science.
Postdocs are well-educated, but by and large they're *not* rich people. Pulling the rug out from under them like this hurts them badly, and it cripples science.
National Science Foundation suspends salary payments, leaving researchers unable to pay their bills
An NSF online payment system remained down after the federal funding freeze was lifted, leaving early-career scientists scrambling to pay bills
www.statnews.com
January 31, 2025 at 12:01 AM
Postdocs aren't getting paychecks, because Trump.
Postdocs are well-educated, but by and large they're *not* rich people. Pulling the rug out from under them like this hurts them badly, and it cripples science.
Postdocs are well-educated, but by and large they're *not* rich people. Pulling the rug out from under them like this hurts them badly, and it cripples science.
Coming up on 20 years in Seattle, and I just now got around to going up to the top of the Smith Tower. A++ would ascend again.
January 21, 2025 at 3:03 AM
Coming up on 20 years in Seattle, and I just now got around to going up to the top of the Smith Tower. A++ would ascend again.
In this article, I take a step back from the nitty gritty immunology to describe how we can use T-cell repertoires from 10Ks of people to build a catalog of humanity's shared T-cell responses to diseases... without (initially) having any idea which groups of T cells respond to which diseases.
ECOclusters: A T-Cell Biomarker Catalog of Humanity’s Shared Responses to Disease
The T cells circulating in an individual’s blood represent a record of their prior immune exposures.
globalforum.diaglobal.org
January 13, 2025 at 4:16 PM
In this article, I take a step back from the nitty gritty immunology to describe how we can use T-cell repertoires from 10Ks of people to build a catalog of humanity's shared T-cell responses to diseases... without (initially) having any idea which groups of T cells respond to which diseases.
Thought 1: being a dungeon master involves a lot of extremely amateur architecture
Thought 2: I wonder if DMs who are actual architects spend all their time making the buildings look right
Thought 3: all wilderness adventures, all the time
Thought 2: I wonder if DMs who are actual architects spend all their time making the buildings look right
Thought 3: all wilderness adventures, all the time
January 13, 2025 at 3:48 AM
Thought 1: being a dungeon master involves a lot of extremely amateur architecture
Thought 2: I wonder if DMs who are actual architects spend all their time making the buildings look right
Thought 3: all wilderness adventures, all the time
Thought 2: I wonder if DMs who are actual architects spend all their time making the buildings look right
Thought 3: all wilderness adventures, all the time
Back in 2020, we did a bunch of work on SARS-CoV-2-responding T cells and put it out there as a preprint. Then we got back to work. 4+ years later, here it is in print!
Congrats to everyone who worked on this, and particularly to those who went the extra mile to get it published, multo post facto!
Congrats to everyone who worked on this, and particularly to those who went the extra mile to get it published, multo post facto!
Frontiers | Magnitude and dynamics of the T-cell response to SARS-CoV-2 infection at both individual and population levels
www.frontiersin.org
January 11, 2025 at 6:00 AM
Back in 2020, we did a bunch of work on SARS-CoV-2-responding T cells and put it out there as a preprint. Then we got back to work. 4+ years later, here it is in print!
Congrats to everyone who worked on this, and particularly to those who went the extra mile to get it published, multo post facto!
Congrats to everyone who worked on this, and particularly to those who went the extra mile to get it published, multo post facto!