TGen
@tgenresearch.bsky.social
A nonprofit institute, translating genomic research into life changing results. TGen is part of City of Hope. Follows & likes are not an endorsement.
Congratulations to TGen - Part of City of Hope clinical professor, Vinodh Narayanan, M.D., on receiving the Roger and Mary Brumback Lifetime Achievement Award at the 2025 Child Neurology Society Meeting.
Photo credit: Keri Ramsey
Photo credit: Keri Ramsey
October 28, 2025 at 10:28 PM
Congratulations to TGen - Part of City of Hope clinical professor, Vinodh Narayanan, M.D., on receiving the Roger and Mary Brumback Lifetime Achievement Award at the 2025 Child Neurology Society Meeting.
Photo credit: Keri Ramsey
Photo credit: Keri Ramsey
@tgenresearch.bsky.social partners to release new technology with @googleresearch.bsky.social and @ucscgenomics.bsky.social: DeepSomatic 🧑🏽💻 This #machinelearning method is a major leap forward for #cancer mutation #detection. More at bit.ly/4nYDDJY and lnkd.in/gQA4frVa
#Research #Genomics
#Research #Genomics
October 23, 2025 at 9:32 PM
@tgenresearch.bsky.social partners to release new technology with @googleresearch.bsky.social and @ucscgenomics.bsky.social: DeepSomatic 🧑🏽💻 This #machinelearning method is a major leap forward for #cancer mutation #detection. More at bit.ly/4nYDDJY and lnkd.in/gQA4frVa
#Research #Genomics
#Research #Genomics
For #postdoc appreciation week, we sat down with Dr. Aya Kamzinain the Division of Early Detection and Prevention at TGen, to learn more about her work and role as a postdoc. Full blog at bit.ly/48jnkT6
#Science #Research #Impact #Thoughtleader #Genomics #foryoupage #fyp
#Science #Research #Impact #Thoughtleader #Genomics #foryoupage #fyp
September 16, 2025 at 5:00 PM
For #postdoc appreciation week, we sat down with Dr. Aya Kamzinain the Division of Early Detection and Prevention at TGen, to learn more about her work and role as a postdoc. Full blog at bit.ly/48jnkT6
#Science #Research #Impact #Thoughtleader #Genomics #foryoupage #fyp
#Science #Research #Impact #Thoughtleader #Genomics #foryoupage #fyp
Reposted by TGen
Interesting @nebanovich.bsky.social @florisbarthel.bsky.social glad we just installed an @elembio.bsky.social Aviti24 @tgenresearch.bsky.social. @aphillippy.bsky.social is this with standard cloudbreak chemistry or the high accuracy ultraQ chemistry
Definitely hard to measure, but here is our best attempt from a new benchmarking paper to be preprinted in the next few weeks. Element appears to be the current king of homopolymers. Illumina does worse than HiFi beyond 20 bp. (This is all measured on human DNA)
September 6, 2025 at 7:15 PM
Interesting @nebanovich.bsky.social @florisbarthel.bsky.social glad we just installed an @elembio.bsky.social Aviti24 @tgenresearch.bsky.social. @aphillippy.bsky.social is this with standard cloudbreak chemistry or the high accuracy ultraQ chemistry
Researchers have identified 2 proteins that could serve as new biomarkers for #pancreatic #cancer. These protein markers can help distinguish cancer from non-cancer and track how patients are responding to treatment. This offers a new direction for the early detection & monitoring. bit.ly/4mbboX0
September 8, 2025 at 8:10 PM
Researchers have identified 2 proteins that could serve as new biomarkers for #pancreatic #cancer. These protein markers can help distinguish cancer from non-cancer and track how patients are responding to treatment. This offers a new direction for the early detection & monitoring. bit.ly/4mbboX0
Reposted by TGen
Yesterday was the last day of @tgenresearch.bsky.social's summer internship supported by the Helios foundation. Bittersweet to say goodbye but happy to see them presenting their great work. Special congrats to Francesca, Lauren, and Yafnelt who were recognized for their outstanding presentations.
August 1, 2025 at 9:38 PM
Yesterday was the last day of @tgenresearch.bsky.social's summer internship supported by the Helios foundation. Bittersweet to say goodbye but happy to see them presenting their great work. Special congrats to Francesca, Lauren, and Yafnelt who were recognized for their outstanding presentations.
Breakthrough news in the fight against lung cancer! 🚨 A new study shows how molecules from a patient's own immune cells (natural killer cells) could reawaken the body's defenses to combat tough tumors for hard-to-treat lung cancers; harnessing the body's own natural killer cells to fight back.
July 25, 2025 at 3:24 PM
Breakthrough news in the fight against lung cancer! 🚨 A new study shows how molecules from a patient's own immune cells (natural killer cells) could reawaken the body's defenses to combat tough tumors for hard-to-treat lung cancers; harnessing the body's own natural killer cells to fight back.
Building the evidence base for engaging all populations in genomics research is key for Participant Engagement and Cancer Genome Sequencing Network (PE-CGS). The newest paper introduces a new framework & strategies for involving community members in #cancer #genomics #research. lnkd.in/gjj-WQ8n
July 11, 2025 at 5:59 PM
Building the evidence base for engaging all populations in genomics research is key for Participant Engagement and Cancer Genome Sequencing Network (PE-CGS). The newest paper introduces a new framework & strategies for involving community members in #cancer #genomics #research. lnkd.in/gjj-WQ8n
Reposted by TGen
But not all mutations block all anti-BCMA therapies from binding and we at @tgenresearch.bsky.social and @cityofhope.bsky.social are integrating the known binding of these agents into our whole genome sequencing reports to ensure patients get the therapy that will work best for them at that point
July 3, 2025 at 4:49 PM
But not all mutations block all anti-BCMA therapies from binding and we at @tgenresearch.bsky.social and @cityofhope.bsky.social are integrating the known binding of these agents into our whole genome sequencing reports to ensure patients get the therapy that will work best for them at that point
Reposted by TGen
ascopubs.org/doi/10.1200/... considering the patient population this is extremely impressive, 1/3 of patients progression free at 5 years, glad to have @cityofhope.bsky.social physician Dr. Myo Htut as one of the coauthors. I for one believe cures are possible in #myeloma @tgenresearch.bsky.social
Long-Term (≥5-Year) Remission and Survival After Treatment With Ciltacabtagene Autoleucel in CARTITUDE-1 Patients With Relapsed/Refractory Multiple Myeloma
CARTITUDE-1 evaluated ciltacabtagene autoleucel (cilta-cel) in patients with heavily
pretreated relapsed/refractory multiple myeloma (RRMM). We describe overall survival
(OS), ≥5-year progression-free...
ascopubs.org
June 7, 2025 at 5:38 PM
ascopubs.org/doi/10.1200/... considering the patient population this is extremely impressive, 1/3 of patients progression free at 5 years, glad to have @cityofhope.bsky.social physician Dr. Myo Htut as one of the coauthors. I for one believe cures are possible in #myeloma @tgenresearch.bsky.social
TGen scientists have found a new weakness in a rare ovarian cancer that might help us treat it better. This could mean new and improved treatments are on the way, even for cancers that were hard to treat before. More at www.tgen.org/news/study-r.... #OvarianCancer #Research
May 23, 2025 at 4:11 PM
TGen scientists have found a new weakness in a rare ovarian cancer that might help us treat it better. This could mean new and improved treatments are on the way, even for cancers that were hard to treat before. More at www.tgen.org/news/study-r.... #OvarianCancer #Research
Liver disease can affect anyone, not just those who are overweight 🤔 A Study found that even healthy-weight people can have fat in their liver, & it might be because of their genes. Learning about these genes can help doctors figure out who's at risk & improve care for everyone.
bit.ly/3YURmas
bit.ly/3YURmas
May 22, 2025 at 8:42 PM
Liver disease can affect anyone, not just those who are overweight 🤔 A Study found that even healthy-weight people can have fat in their liver, & it might be because of their genes. Learning about these genes can help doctors figure out who's at risk & improve care for everyone.
bit.ly/3YURmas
bit.ly/3YURmas
Where science meets business🤝An insider’s perspective on how today’s #biomedical research translates into tomorrow's treatments. Stephanie Pond, Ph.D., shared how her team works to identify gaps in current research tools, & help commercialize TGen’s research discoveries. Listen today🎙️ bit.ly/3YYzjzU
May 19, 2025 at 9:01 PM
Where science meets business🤝An insider’s perspective on how today’s #biomedical research translates into tomorrow's treatments. Stephanie Pond, Ph.D., shared how her team works to identify gaps in current research tools, & help commercialize TGen’s research discoveries. Listen today🎙️ bit.ly/3YYzjzU
4️⃣ things #emerging #scientists should do as they prepare for a role in research. Ignazio S Piras, Ph.D., shares tips for preparing for a world in research, and how having a unique educational background has allowed him to participate in a wide variety of projects.
www.linkedin.com/.../world-wi...
www.linkedin.com/.../world-wi...
May 12, 2025 at 3:56 PM
4️⃣ things #emerging #scientists should do as they prepare for a role in research. Ignazio S Piras, Ph.D., shares tips for preparing for a world in research, and how having a unique educational background has allowed him to participate in a wide variety of projects.
www.linkedin.com/.../world-wi...
www.linkedin.com/.../world-wi...
Congratulations to Daniel D. Von Hoff, M.D., F.A.C.P., distinguished professor at TGen and @cityofhope.bsky.social, on being recognized at the #AACR25 Partners in Progress Reception for his immeasurable contributions to AACR, cancer research and patient care!
April 28, 2025 at 5:19 PM
Congratulations to Daniel D. Von Hoff, M.D., F.A.C.P., distinguished professor at TGen and @cityofhope.bsky.social, on being recognized at the #AACR25 Partners in Progress Reception for his immeasurable contributions to AACR, cancer research and patient care!
🧬 Today is National DNA Day 🧬
We wouldn't be where we are today without the hard work of Friedrich Miescher (1869) and Rosalind Franklin, James Watson, and Francis Crick (1953). Thanks to their contributions, the foundation of genetics and genomic sciences is strong.
We wouldn't be where we are today without the hard work of Friedrich Miescher (1869) and Rosalind Franklin, James Watson, and Francis Crick (1953). Thanks to their contributions, the foundation of genetics and genomic sciences is strong.
April 25, 2025 at 3:59 PM
🧬 Today is National DNA Day 🧬
We wouldn't be where we are today without the hard work of Friedrich Miescher (1869) and Rosalind Franklin, James Watson, and Francis Crick (1953). Thanks to their contributions, the foundation of genetics and genomic sciences is strong.
We wouldn't be where we are today without the hard work of Friedrich Miescher (1869) and Rosalind Franklin, James Watson, and Francis Crick (1953). Thanks to their contributions, the foundation of genetics and genomic sciences is strong.
TGen is proud to present at the 2025 @theaacr.bsky.social Annual Meeting.
Be sure to stop by the @cityofhope.bsky.social and TGen booth at the Exhibit Hall from April 27 - 30.
#AACR25 #Cancer #Research
Be sure to stop by the @cityofhope.bsky.social and TGen booth at the Exhibit Hall from April 27 - 30.
#AACR25 #Cancer #Research
April 23, 2025 at 4:30 PM
TGen is proud to present at the 2025 @theaacr.bsky.social Annual Meeting.
Be sure to stop by the @cityofhope.bsky.social and TGen booth at the Exhibit Hall from April 27 - 30.
#AACR25 #Cancer #Research
Be sure to stop by the @cityofhope.bsky.social and TGen booth at the Exhibit Hall from April 27 - 30.
#AACR25 #Cancer #Research
💡Remarkable Research💡The #MindCrowd mobile lab is a unique research project bringing the lab to the community. Research can be scary & hard to find the time to participate, so the MindCrowd team goes to communities allowing individuals to be a part of brain research. More at tgen.org/mindcrowd 🧠
April 18, 2025 at 4:24 PM
💡Remarkable Research💡The #MindCrowd mobile lab is a unique research project bringing the lab to the community. Research can be scary & hard to find the time to participate, so the MindCrowd team goes to communities allowing individuals to be a part of brain research. More at tgen.org/mindcrowd 🧠
Reposted by TGen
Great work on whole genome assembly using @nanoporetech.com and @pacbio.bsky.social sequencing @tgenresearch.bsky.social part of @cityofhope.bsky.social
But mostly, massive credit to first authors @trhyker.bsky.social + @yuehao.bsky.social , and co-authors @pedalheadphx.bsky.social @mishakolmogorov.bsky.social @benedictpaten.bsky.social @mitchiela.bsky.social @msstephkayb.bsky.social + others not on here (yet) 🙏
🔗 www.biorxiv.org/content/10.1...
🔗 www.biorxiv.org/content/10.1...
Diploid genome assembly of human fibroblast cell lines enables clone specific variant calling, improved read mapping and accurate phasing
Human cell lines are fundamental tools in biomedical research and are widely used in disease modeling, drug development, and many other domains. Here, we present chromosome-level, phased diploid genom...
www.biorxiv.org
April 17, 2025 at 3:05 AM
Great work on whole genome assembly using @nanoporetech.com and @pacbio.bsky.social sequencing @tgenresearch.bsky.social part of @cityofhope.bsky.social
💡 "Good researchers and leaders figure out the right questions to ask." 💡Meet Dr. @heinimnatri.bsky.social, Research Assistant Professor. She shares insights on team science, mentorship, & her recent breakthrough in glioblastoma research—helping pave the way for new clinical trials in CAR T therapy.
April 14, 2025 at 7:46 PM
💡 "Good researchers and leaders figure out the right questions to ask." 💡Meet Dr. @heinimnatri.bsky.social, Research Assistant Professor. She shares insights on team science, mentorship, & her recent breakthrough in glioblastoma research—helping pave the way for new clinical trials in CAR T therapy.
🫁 Pulmonary fibrosis is a devastating disease with no cure—only a lung transplant. But new research from TGen, uncovers hidden disease markers in seemingly healthy lung tissue using advanced spatial transcriptomics.🎙️ TGen Talks w/@nebanovich.bsky.social breaks it down at www.tgen.org/tgen-talks/
April 11, 2025 at 9:32 PM
🫁 Pulmonary fibrosis is a devastating disease with no cure—only a lung transplant. But new research from TGen, uncovers hidden disease markers in seemingly healthy lung tissue using advanced spatial transcriptomics.🎙️ TGen Talks w/@nebanovich.bsky.social breaks it down at www.tgen.org/tgen-talks/
We’re uncovering clues about what makes us human!
In a recent Nature paper, TGen Drs. Nicholas Schork and Agnes Chan joined Germany’s Dr. Michael Hiller in a study that compared ~20K human genes with six ape genomes using T2T assemblies.
www.nature.com/articles/s41...
In a recent Nature paper, TGen Drs. Nicholas Schork and Agnes Chan joined Germany’s Dr. Michael Hiller in a study that compared ~20K human genes with six ape genomes using T2T assemblies.
www.nature.com/articles/s41...
Complete sequencing of ape genomes - Nature
Complete sequences of chromosomes telomere-to-telomere from chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang provide a comprehensive and valuable resource for future evol...
www.nature.com
April 10, 2025 at 4:46 PM
We’re uncovering clues about what makes us human!
In a recent Nature paper, TGen Drs. Nicholas Schork and Agnes Chan joined Germany’s Dr. Michael Hiller in a study that compared ~20K human genes with six ape genomes using T2T assemblies.
www.nature.com/articles/s41...
In a recent Nature paper, TGen Drs. Nicholas Schork and Agnes Chan joined Germany’s Dr. Michael Hiller in a study that compared ~20K human genes with six ape genomes using T2T assemblies.
www.nature.com/articles/s41...
New prepreint alert 🚨 Great work by all the collaborators and shoutout to TGen's @heinimnatri.bsky.social work on this!
Excited to share our new work exploring strategies to overcome resistance to CAR T cell therapy in solid tumors. Using scRNA-seq, mouse models, and functional studies, our work points to SPP1 signaling in the TME as a critical component of this resistance. www.biorxiv.org/content/10.1...
www.biorxiv.org
April 3, 2025 at 4:06 PM
New prepreint alert 🚨 Great work by all the collaborators and shoutout to TGen's @heinimnatri.bsky.social work on this!
Reposted by TGen
Excited to share our new work exploring strategies to overcome resistance to CAR T cell therapy in solid tumors. Using scRNA-seq, mouse models, and functional studies, our work points to SPP1 signaling in the TME as a critical component of this resistance. www.biorxiv.org/content/10.1...
www.biorxiv.org
April 3, 2025 at 2:16 PM
Excited to share our new work exploring strategies to overcome resistance to CAR T cell therapy in solid tumors. Using scRNA-seq, mouse models, and functional studies, our work points to SPP1 signaling in the TME as a critical component of this resistance. www.biorxiv.org/content/10.1...