Ted Satterthwaite
@ted-satterthwaite.bsky.social
McLure II Professor
PennLINC | University of Pennsylvania
www.pennlinc.io
neurodevelopment, neuroimaging, neuroinformatics, & mental health
PennLINC | University of Pennsylvania
www.pennlinc.io
neurodevelopment, neuroimaging, neuroinformatics, & mental health
Delighted to see the paper describing the Reproducible Brain Charts open data resource now out in @cp-neuron.bsky.social. Paper + link to data below; huge congrats to @goliashf.bsky.social @milhammichael.bsky.social and the whole RBC team. Lots of people (>2,500 downloads) are already using RBC!
September 24, 2025 at 1:23 PM
Delighted to see the paper describing the Reproducible Brain Charts open data resource now out in @cp-neuron.bsky.social. Paper + link to data below; huge congrats to @goliashf.bsky.social @milhammichael.bsky.social and the whole RBC team. Lots of people (>2,500 downloads) are already using RBC!
Finally, when predicting cognitive performance from different sets of bundle features, GQI and SS3T outperformed CSD. Overall, we observed prediction accuracies comparable to those predicting cognition from WM features extracted from more advanced scans. 8/n
September 7, 2025 at 3:36 PM
Finally, when predicting cognitive performance from different sets of bundle features, GQI and SS3T outperformed CSD. Overall, we observed prediction accuracies comparable to those predicting cognition from WM features extracted from more advanced scans. 8/n
We also found that SS3T had the highest ICC for both volumetric and microstructure (FA, MD) features 7/n
September 7, 2025 at 3:35 PM
We also found that SS3T had the highest ICC for both volumetric and microstructure (FA, MD) features 7/n
But are reconstructions also biologically plausible? Amelie found that GQI had the highest specificity -- but often yielded incomplete bundles. CSD showed the opposite-- over inclusive bundles with lower specificity. SS3T showed the best balance between sensitivity and specificity. 6/n
September 7, 2025 at 3:32 PM
But are reconstructions also biologically plausible? Amelie found that GQI had the highest specificity -- but often yielded incomplete bundles. CSD showed the opposite-- over inclusive bundles with lower specificity. SS3T showed the best balance between sensitivity and specificity. 6/n
But are reconstructions also biologically plausible? Amelie found that GQI had the highest specificity -- but often yielded incomplete bundles. CSD showed the opposite-- over inclusive bundles with lower specificity. SS3T showed the best balance between sensitivity and specificity. 6/n
September 7, 2025 at 3:32 PM
But are reconstructions also biologically plausible? Amelie found that GQI had the highest specificity -- but often yielded incomplete bundles. CSD showed the opposite-- over inclusive bundles with lower specificity. SS3T showed the best balance between sensitivity and specificity. 6/n
Amelie found that all major WM bundles can be reliably reconstructed for all three reconstruction methods. Furthermore, methods showed high discriminability (>0.94), but SS3T yielded the highest. 5/n
September 7, 2025 at 3:28 PM
Amelie found that all major WM bundles can be reliably reconstructed for all three reconstruction methods. Furthermore, methods showed high discriminability (>0.94), but SS3T yielded the highest. 5/n
In our study, Amelie reconstructed 60 WM tracts in test-retest data from 1221 subjects of the PNC dataset with single-shell, 32-direction dMRI acquisitions. Three methods for ODF reconstruction applicable to this type of data were compared: GQI, CSD, and SS3T. 4/n
September 7, 2025 at 3:01 PM
In our study, Amelie reconstructed 60 WM tracts in test-retest data from 1221 subjects of the PNC dataset with single-shell, 32-direction dMRI acquisitions. Three methods for ODF reconstruction applicable to this type of data were compared: GQI, CSD, and SS3T. 4/n
New preprint from stellar IRTG PhD student Amelie Rauland + team on white matter bundle reconstruction! Shows that WM bundles can be reliably extracted from simple 32-direction dMRI & features predict cognition - huge potential for legacy and clinical data. Thread 👇
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
September 7, 2025 at 2:59 PM
New preprint from stellar IRTG PhD student Amelie Rauland + team on white matter bundle reconstruction! Shows that WM bundles can be reliably extracted from simple 32-direction dMRI & features predict cognition - huge potential for legacy and clinical data. Thread 👇
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
CONGRATS TO DOCTOR @audreycluo.bsky.social !!! Last week, Dr. Luo knocked our collective socks off with a thesis defense for the ages. Her presentation on "Axes of Hierarchical Brain Development" was magnificent -- beautiful science, presented in an incredibly accessible and engaging way. WOO!!!!
August 14, 2025 at 9:06 PM
CONGRATS TO DOCTOR @audreycluo.bsky.social !!! Last week, Dr. Luo knocked our collective socks off with a thesis defense for the ages. Her presentation on "Axes of Hierarchical Brain Development" was magnificent -- beautiful science, presented in an incredibly accessible and engaging way. WOO!!!!
@valeriejsydnor.bsky.social giving a killer talk on prefrontal myelin development at #OHBM2025
June 26, 2025 at 11:39 PM
@valeriejsydnor.bsky.social giving a killer talk on prefrontal myelin development at #OHBM2025
The incredible @laurapritschet.bsky.social giving a truly stellar talk on Dynamic endocrine modulation of the nervous system at #OHBM2025
June 26, 2025 at 6:20 AM
The incredible @laurapritschet.bsky.social giving a truly stellar talk on Dynamic endocrine modulation of the nervous system at #OHBM2025
Amelie Rauland (all star via IRTG student w/ @sbe.bsky.social ) will be presenting "Benchmarking Reconstruction Methods for Bundle Segmentation in Single-Shell dMRI" on Friday and Saturday, Poster #1283
June 25, 2025 at 7:24 AM
Amelie Rauland (all star via IRTG student w/ @sbe.bsky.social ) will be presenting "Benchmarking Reconstruction Methods for Bundle Segmentation in Single-Shell dMRI" on Friday and Saturday, Poster #1283
@bencephalon.bsky.social from @aarona-b.bsky.social 's lab will be presenting "Integrating clinical and research imaging to uncover neuroanatomic deviations in 22q11.2 deletions" Wed, June 25, 13:15 -15:15 & Thurs, June 26, 13:45 -15:45; Poster #697
June 25, 2025 at 5:26 AM
@bencephalon.bsky.social from @aarona-b.bsky.social 's lab will be presenting "Integrating clinical and research imaging to uncover neuroanatomic deviations in 22q11.2 deletions" Wed, June 25, 13:15 -15:15 & Thurs, June 26, 13:45 -15:45; Poster #697
@kevin-y-sun.bsky.social will be presenting his work on "Copy Number Variant Risk Scores Are Associated with Personalized Functional Brain Network Topography" Wed, June 25, 13:15 - 15:15 & Thus, June 26, 13:45 - 15:45
June 25, 2025 at 12:50 AM
@kevin-y-sun.bsky.social will be presenting his work on "Copy Number Variant Risk Scores Are Associated with Personalized Functional Brain Network Topography" Wed, June 25, 13:15 - 15:15 & Thus, June 26, 13:45 - 15:45
@audreycluo.bsky.social will be presenting her fab work on "Two Axes of White Matter Development" on Wed, June 25, 13:15 -15:15 & Thurs, June 26, 13:45 -15:45; Poster #1010.
June 25, 2025 at 12:49 AM
@audreycluo.bsky.social will be presenting her fab work on "Two Axes of White Matter Development" on Wed, June 25, 13:15 -15:15 & Thurs, June 26, 13:45 -15:45; Poster #1010.
Want more RBC? Come chat with me at the RBC poster Friday, Jun 27 & Saturday June 28: 13:45 – 15:45 PM; Poster #1816.
June 25, 2025 at 12:48 AM
Want more RBC? Come chat with me at the RBC poster Friday, Jun 27 & Saturday June 28: 13:45 – 15:45 PM; Poster #1816.
I will provide a (poor) substitute for @goliashf.bsky.social and discuss Reproducible Brain Charts as part of the "OSR Table Talk on Recommended Practices in Open Science" Friday, June 27, from 8–9 AM in Exhibition Hall 1
June 25, 2025 at 12:46 AM
I will provide a (poor) substitute for @goliashf.bsky.social and discuss Reproducible Brain Charts as part of the "OSR Table Talk on Recommended Practices in Open Science" Friday, June 27, from 8–9 AM in Exhibition Hall 1
@goliashf.bsky.social is ALSO presenting "Systematic dynamical profiling to discover and manipulate the dynamical regime of the primate brain" Thursday, Jun 26: 9:00 AM – 10:15 AM during the computational dynamics symposium in Room M2.
June 25, 2025 at 12:44 AM
@goliashf.bsky.social is ALSO presenting "Systematic dynamical profiling to discover and manipulate the dynamical regime of the primate brain" Thursday, Jun 26: 9:00 AM – 10:15 AM during the computational dynamics symposium in Room M2.
@goliashf.bsky.social is presenting (via video, 🥲) "Reproducible Brain Charts: An Open Data Resource for Mapping the Developing Brain and Mental Health" on Friday, Jun 27: 11:30 AM – 12:45 PM. This talk is part the Neuroinformatics and Data Sharing session in Room M3 (Mezzanine Level).
June 25, 2025 at 12:41 AM
@goliashf.bsky.social is presenting (via video, 🥲) "Reproducible Brain Charts: An Open Data Resource for Mapping the Developing Brain and Mental Health" on Friday, Jun 27: 11:30 AM – 12:45 PM. This talk is part the Neuroinformatics and Data Sharing session in Room M3 (Mezzanine Level).
@stevenmeisler.com is presenting "A quality-rated, analysis-ready release of 26,174 dMRI sessions from the ABCD Study" Friday / Saturday 1810. Wooo!!!!
June 25, 2025 at 12:39 AM
@stevenmeisler.com is presenting "A quality-rated, analysis-ready release of 26,174 dMRI sessions from the ABCD Study" Friday / Saturday 1810. Wooo!!!!
@audreycluo.bsky.social giving a great talk on two major axes of white matter development at Gradients Workshop #OHBM
June 23, 2025 at 7:53 AM
@audreycluo.bsky.social giving a great talk on two major axes of white matter development at Gradients Workshop #OHBM