A big shout out to all of the authors on this work, that made it possible: David Maridas, Hao Chen, Pushpanathan Muthuirulan, Zun Liu, Evelyn Jagoda, Siddharth Yarlagadda, Mohammadreza Movahhedi, Benedikt Proffen, Babak Dashtdar, Mahdi Aghaalikhani, Daniel Richard, Vicki Rosen, Ata M. Kiapour.

Not only was this published but she got the cover for the issue and a special news and views on her work:
acrjournals.onlinelibrary.wiley.com/doi/epdf/10....

Thanks Michael! This was lots of fun to work on! My post-doc Gayani is terrific (and now on the job market if there are group leader positions in Germany)

Thanks Venki!!

We want to thank the NIH for providing federal funding for this work. And we note here that this grant was illegally terminated by the federal administration causing future studies on the manner in which these changes influence human disease risk and birth process to be ended.

We want to thank the individuals who consented to provide human samples as they appreciate that knowledge is critical to understanding the human condition including our derived disease risks.

We want to thank the Birth Defects Research Laboratory at the University of Washington for their assistance in ethically collecting human samples.

We want to thank the following scientists/staff/curators for their help: N Shubin, J Hanken (MCZ), M Gage (MCZ), S Turney (MCZ), B Zimkus (MCZ), J Woodward (MCZ), J Austiff (MCZ), J Chaumel (MCZ), T Stewart, E Hoeger (AMNH), M Surovy (AMNH), L Caspers (AMNH)

Overall, we argue that the ilium is part of highly important adaptive musculoskeletal pelvic complex that is
shaped during evolution under the constraints of complex polygenic underpinnings.

Third, the reorientation of the growth plate, and subsequent changes in ossification, now cause a hip joint to face more anterior/ventral, and this might lead to greater loading issues on the femoral head/neck and increased rise of hip disease.

Likewise, obstetrical-dilemma models that attempt to model the human pelvis as resulting from a chimp-like pattern of growth may be off. And this critical shift will have different relationships to permitting or constraining later human brain growth and in relationship to bipedalism.

Second, that this growth plate shift, preceded human brain expansion and thus a widened canal configuration due to iliac bones growing in a different plane may have been a prerequisite and may have permitted later brain expansion in humans.

This growth plate shift occurred likely at the base of many hominins indicating that the adaptive radiation of hominins from 4.5-2.5 MYA might have resulted from the benefits this structural innovation had to bipedalism.