T cell Vaccines Lab (Swadling UCL) 🧬👩🏽🔬
@tcellvaccineucl.bsky.social
Sometimes tweeting about T cells, Vaccines, Viruses, TCRs, Immunogen Design, AI, Viral Seq Evolution...
PI: Leo Swadling
@IIT_UCL 🍐
www.researchgate.net/profile/Leo-Swadling
profiles.ucl.ac.uk/61477-leo-swadling
PI: Leo Swadling
@IIT_UCL 🍐
www.researchgate.net/profile/Leo-Swadling
profiles.ucl.ac.uk/61477-leo-swadling
Reposted by T cell Vaccines Lab (Swadling UCL) 🧬👩🏽🔬
Very happy to share our latest manuscript about TCR-epitope recognition specificity: www.biorxiv.org/content/10.1...
www.biorxiv.org
November 18, 2025 at 7:21 AM
Very happy to share our latest manuscript about TCR-epitope recognition specificity: www.biorxiv.org/content/10.1...
🚨Preprint🚨: To better utilise the potential for cross-protective T cells in HPV vaccines we would like to take a rational approach to designing T-cell inducing HPV vaccines (prophylactic and therapeutic) ⚔️
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
November 17, 2025 at 3:18 PM
🚨Preprint🚨: To better utilise the potential for cross-protective T cells in HPV vaccines we would like to take a rational approach to designing T-cell inducing HPV vaccines (prophylactic and therapeutic) ⚔️
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by T cell Vaccines Lab (Swadling UCL) 🧬👩🏽🔬
@biorxivpreprint.bsky.social REFLEX, a Novel Immune Profiling Assay, Combining TCR Repertoire and Multiome at Massively Scalable Single-cell Resolution to Catapult Exploration of T-cell Derived Immunity
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 29, 2025 at 2:13 AM
@biorxivpreprint.bsky.social REFLEX, a Novel Immune Profiling Assay, Combining TCR Repertoire and Multiome at Massively Scalable Single-cell Resolution to Catapult Exploration of T-cell Derived Immunity
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by T cell Vaccines Lab (Swadling UCL) 🧬👩🏽🔬
Your morning commute isn't just routine – It's part of an invisible network that can help viruses spread. New research reveals how modelling disease transmission based on daily commuting patterns could transform pandemic response strategies.
Swipe to learn more. 👉
Swipe to learn more. 👉
October 29, 2025 at 8:00 AM
Your morning commute isn't just routine – It's part of an invisible network that can help viruses spread. New research reveals how modelling disease transmission based on daily commuting patterns could transform pandemic response strategies.
Swipe to learn more. 👉
Swipe to learn more. 👉
Reposted by T cell Vaccines Lab (Swadling UCL) 🧬👩🏽🔬
Review @natrevcancer.nature.com @stjuderesearch.bsky.social
Epigenetic regulation of T cell exhaustion in cancer
www.nature.com/articles/s41...
Epigenetic regulation of T cell exhaustion in cancer
www.nature.com/articles/s41...
Epigenetic regulation of T cell exhaustion in cancer - Nature Reviews Cancer
Transcriptional and epigenetic mechanisms governing T cell exhaustion substantially impact immunotherapy effectiveness. In this Review, Kang et al. outline epigenetic regulatory programmes that i...
www.nature.com
October 27, 2025 at 3:40 PM
Review @natrevcancer.nature.com @stjuderesearch.bsky.social
Epigenetic regulation of T cell exhaustion in cancer
www.nature.com/articles/s41...
Epigenetic regulation of T cell exhaustion in cancer
www.nature.com/articles/s41...
Ever heard of this #vaccination side effect? SARS-CoV-2 mRNA vaccination significantly increased anti tumour responses and survival in patients with metastatic melanoma and NSCLC undergoing treatment with ICIs.
www.nature.com/articles/s41...
#vaccineswork #tcells #immunology
www.nature.com/articles/s41...
#vaccineswork #tcells #immunology
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
www.nature.com
October 24, 2025 at 9:26 AM
Ever heard of this #vaccination side effect? SARS-CoV-2 mRNA vaccination significantly increased anti tumour responses and survival in patients with metastatic melanoma and NSCLC undergoing treatment with ICIs.
www.nature.com/articles/s41...
#vaccineswork #tcells #immunology
www.nature.com/articles/s41...
#vaccineswork #tcells #immunology
Reposted by T cell Vaccines Lab (Swadling UCL) 🧬👩🏽🔬
👶✈️ Balancing caregiving and academic travel?
Join Dr. Laura Pallett for "The Dual Demands of Academic Travel and Caregiving"
🗓️ Sept 25 | 🕒15:00 CEST
🔗https://tinyurl.com/yefis2025-ia2
Hosted by the Improving Academia group of yEFIS
Join Dr. Laura Pallett for "The Dual Demands of Academic Travel and Caregiving"
🗓️ Sept 25 | 🕒15:00 CEST
🔗https://tinyurl.com/yefis2025-ia2
Hosted by the Improving Academia group of yEFIS
August 25, 2025 at 3:11 PM
👶✈️ Balancing caregiving and academic travel?
Join Dr. Laura Pallett for "The Dual Demands of Academic Travel and Caregiving"
🗓️ Sept 25 | 🕒15:00 CEST
🔗https://tinyurl.com/yefis2025-ia2
Hosted by the Improving Academia group of yEFIS
Join Dr. Laura Pallett for "The Dual Demands of Academic Travel and Caregiving"
🗓️ Sept 25 | 🕒15:00 CEST
🔗https://tinyurl.com/yefis2025-ia2
Hosted by the Improving Academia group of yEFIS
An HA/NP/IL-1B adenovirus led to a different profile of lung-resident Trms than natural H1N1 infection with the adjuvanted vaccine leading to longer lived lung-resident Trms than infection.
pmc.ncbi.nlm.nih.gov/articles/PMC...
#immunology #vaccine #Tcell #memory
pmc.ncbi.nlm.nih.gov/articles/PMC...
#immunology #vaccine #Tcell #memory
Inflammatory conditions shape phenotypic and functional characteristics of lung-resident memory T cells in mice
Lung tissue-resident memory T cells (TRM) are critical for the local control of respiratory tract infections caused by influenza A viruses (IAV). Here we compare TRM populations induced by intranasal ...
pmc.ncbi.nlm.nih.gov
July 3, 2025 at 11:14 AM
An HA/NP/IL-1B adenovirus led to a different profile of lung-resident Trms than natural H1N1 infection with the adjuvanted vaccine leading to longer lived lung-resident Trms than infection.
pmc.ncbi.nlm.nih.gov/articles/PMC...
#immunology #vaccine #Tcell #memory
pmc.ncbi.nlm.nih.gov/articles/PMC...
#immunology #vaccine #Tcell #memory
Another nice study illustrating that targeting responses to the nasal mucosa could be superior to systemic administration. The CAF09b adjuvant plus recombinant protein in an i.n. vaccine induced better nasal IgA and CD8 responses than i.m. mRNA.
June 18, 2025 at 9:23 AM
Another nice study illustrating that targeting responses to the nasal mucosa could be superior to systemic administration. The CAF09b adjuvant plus recombinant protein in an i.n. vaccine induced better nasal IgA and CD8 responses than i.m. mRNA.
Cool to see this upcoming phase 2 clinical trial for aerosolised vaccine formulations, with planned measurements of lung T cell responses
publications.ersnet.org/content/erjo...
#clinicaltrial #tcell #vaccineswork #immunology #vaccine
publications.ersnet.org/content/erjo...
#clinicaltrial #tcell #vaccineswork #immunology #vaccine
publications.ersnet.org
June 17, 2025 at 9:04 AM
Cool to see this upcoming phase 2 clinical trial for aerosolised vaccine formulations, with planned measurements of lung T cell responses
publications.ersnet.org/content/erjo...
#clinicaltrial #tcell #vaccineswork #immunology #vaccine
publications.ersnet.org/content/erjo...
#clinicaltrial #tcell #vaccineswork #immunology #vaccine
New interesting data on the role of T cells in Ad26-COV2.S-mediated immunity to SARS-CoV-2! Back in 2021, a phase 3 study showed that single dose was able to confer protection from symptomatic COVID-19 and reduced severity of any breakthrough infections.
June 16, 2025 at 10:38 AM
New interesting data on the role of T cells in Ad26-COV2.S-mediated immunity to SARS-CoV-2! Back in 2021, a phase 3 study showed that single dose was able to confer protection from symptomatic COVID-19 and reduced severity of any breakthrough infections.
Jamie and Leo will be at #ExRdFest Saturday representing IMMPROVE
🧪🧬at the "would you get sick for science" stand 🧪🧬
talking about human challenge, vaccines and immunology!
www.greatexhibitionroadfestival.co.uk
www.imperial.ac.uk/institute-of...
immprove.ac.uk
🧪🧬at the "would you get sick for science" stand 🧪🧬
talking about human challenge, vaccines and immunology!
www.greatexhibitionroadfestival.co.uk
www.imperial.ac.uk/institute-of...
immprove.ac.uk
Home - The Great Exhibition Road Festival
The Great Exhibition Road Festival is an annual celebration of science and the arts in South Kensington, London.
www.greatexhibitionroadfestival.co.uk
June 3, 2025 at 7:54 PM
Jamie and Leo will be at #ExRdFest Saturday representing IMMPROVE
🧪🧬at the "would you get sick for science" stand 🧪🧬
talking about human challenge, vaccines and immunology!
www.greatexhibitionroadfestival.co.uk
www.imperial.ac.uk/institute-of...
immprove.ac.uk
🧪🧬at the "would you get sick for science" stand 🧪🧬
talking about human challenge, vaccines and immunology!
www.greatexhibitionroadfestival.co.uk
www.imperial.ac.uk/institute-of...
immprove.ac.uk
Reposted by T cell Vaccines Lab (Swadling UCL) 🧬👩🏽🔬
Extensive Intra-host evolution and T cell escape by SARS-CoV-2 in a 2.5-year persistent infection of an immunocompromised host https://www.medrxiv.org/content/10.1101/2025.05.28.25328480v1
May 29, 2025 at 4:55 AM
Extensive Intra-host evolution and T cell escape by SARS-CoV-2 in a 2.5-year persistent infection of an immunocompromised host https://www.medrxiv.org/content/10.1101/2025.05.28.25328480v1
We also have two new students, Priya and Nistha. Priya will be using wet and dry lab work to identify conserved T cell targets in HCoVs for vaccine design, and Nishtha will be studying how varied inhaled vaccines stimulate innate immunity and effects on T cell responses (3/3)
May 16, 2025 at 3:01 PM
We also have two new students, Priya and Nistha. Priya will be using wet and dry lab work to identify conserved T cell targets in HCoVs for vaccine design, and Nishtha will be studying how varied inhaled vaccines stimulate innate immunity and effects on T cell responses (3/3)
We're proud to host Dr Xiuyuan Lu from Osaka University as part of the IIT & IFReC exchange programme. She comes with great skills in analysing T cell vaccination responses. We're looking forward to her upcoming talk and of course future collaboration! (2/3)
#UCL #IFReC #vaccine
#UCL #IFReC #vaccine
May 16, 2025 at 3:00 PM
Standing room only our recent lab meeting! The group is growing fast, and lots of great science will surely come soon! (1/3)
May 16, 2025 at 2:59 PM
Standing room only our recent lab meeting! The group is growing fast, and lots of great science will surely come soon! (1/3)
(2/2)
My final thought for the day, is that from mechanistic insights or enhancing and developing medicines, it’s exciting to see quantitative research taking increasing space in immunology. Let’s keep the momentum going!
Postdoc Peter, signing off.
#qimmunoday
My final thought for the day, is that from mechanistic insights or enhancing and developing medicines, it’s exciting to see quantitative research taking increasing space in immunology. Let’s keep the momentum going!
Postdoc Peter, signing off.
#qimmunoday
April 10, 2025 at 5:06 PM
(2/2)
My final thought for the day, is that from mechanistic insights or enhancing and developing medicines, it’s exciting to see quantitative research taking increasing space in immunology. Let’s keep the momentum going!
Postdoc Peter, signing off.
#qimmunoday
My final thought for the day, is that from mechanistic insights or enhancing and developing medicines, it’s exciting to see quantitative research taking increasing space in immunology. Let’s keep the momentum going!
Postdoc Peter, signing off.
#qimmunoday
(1/2)
Another successful #qimmuno day has drawn to a close, but discussions continue in the pub around the corner! Congrats to the organising committee @qimmuno.bsky.social for an excellent day and to all the speakers for engaging talks.
Another successful #qimmuno day has drawn to a close, but discussions continue in the pub around the corner! Congrats to the organising committee @qimmuno.bsky.social for an excellent day and to all the speakers for engaging talks.
April 10, 2025 at 5:05 PM
(1/2)
Another successful #qimmuno day has drawn to a close, but discussions continue in the pub around the corner! Congrats to the organising committee @qimmuno.bsky.social for an excellent day and to all the speakers for engaging talks.
Another successful #qimmuno day has drawn to a close, but discussions continue in the pub around the corner! Congrats to the organising committee @qimmuno.bsky.social for an excellent day and to all the speakers for engaging talks.
(3/3)
Xiaowen Chen was the final presenter, and presented novel research into how we can infer resource competition from dynamic abundance data. A very interesting topic, which has some cool potential overlaps with T and B cell competition for antigens and/or cytokines.
Now for posters!
Xiaowen Chen was the final presenter, and presented novel research into how we can infer resource competition from dynamic abundance data. A very interesting topic, which has some cool potential overlaps with T and B cell competition for antigens and/or cytokines.
Now for posters!
April 10, 2025 at 2:46 PM
(3/3)
Xiaowen Chen was the final presenter, and presented novel research into how we can infer resource competition from dynamic abundance data. A very interesting topic, which has some cool potential overlaps with T and B cell competition for antigens and/or cytokines.
Now for posters!
Xiaowen Chen was the final presenter, and presented novel research into how we can infer resource competition from dynamic abundance data. A very interesting topic, which has some cool potential overlaps with T and B cell competition for antigens and/or cytokines.
Now for posters!
(2/3)
Pebs Edwards presented some interesting data on the TCR repertoire in patients with lynch syndrome. A personal highlight for me was the 2 year persistence of neo-antigen clonotypes with apparent subsequent reactivation in at least one patient.
Pebs Edwards presented some interesting data on the TCR repertoire in patients with lynch syndrome. A personal highlight for me was the 2 year persistence of neo-antigen clonotypes with apparent subsequent reactivation in at least one patient.
April 10, 2025 at 2:46 PM
(2/3)
Pebs Edwards presented some interesting data on the TCR repertoire in patients with lynch syndrome. A personal highlight for me was the 2 year persistence of neo-antigen clonotypes with apparent subsequent reactivation in at least one patient.
Pebs Edwards presented some interesting data on the TCR repertoire in patients with lynch syndrome. A personal highlight for me was the 2 year persistence of neo-antigen clonotypes with apparent subsequent reactivation in at least one patient.
(1/2)
Final set of talks now. Aubin Ramon started by describing his work to develop NanoMelt for nanobody thermostability assessment. The model uses ensemble learning on just 640 sequences, but accurately predicted Tm in a selection of nanobodies with at least 30% distance from the training set.
Final set of talks now. Aubin Ramon started by describing his work to develop NanoMelt for nanobody thermostability assessment. The model uses ensemble learning on just 640 sequences, but accurately predicted Tm in a selection of nanobodies with at least 30% distance from the training set.
April 10, 2025 at 2:45 PM
(1/2)
Final set of talks now. Aubin Ramon started by describing his work to develop NanoMelt for nanobody thermostability assessment. The model uses ensemble learning on just 640 sequences, but accurately predicted Tm in a selection of nanobodies with at least 30% distance from the training set.
Final set of talks now. Aubin Ramon started by describing his work to develop NanoMelt for nanobody thermostability assessment. The model uses ensemble learning on just 640 sequences, but accurately predicted Tm in a selection of nanobodies with at least 30% distance from the training set.
(2/2)
Alastar Phelan then spoke about his mathematical modelling approach to enhance signal detection in dual pulse nucleoside labelling experiments for improving cell cycle analysis.
Both speakers showcased their work really well, armed with only a pen and whiteboard!
#qimmunoday
Alastar Phelan then spoke about his mathematical modelling approach to enhance signal detection in dual pulse nucleoside labelling experiments for improving cell cycle analysis.
Both speakers showcased their work really well, armed with only a pen and whiteboard!
#qimmunoday
April 10, 2025 at 1:36 PM
(2/2)
Alastar Phelan then spoke about his mathematical modelling approach to enhance signal detection in dual pulse nucleoside labelling experiments for improving cell cycle analysis.
Both speakers showcased their work really well, armed with only a pen and whiteboard!
#qimmunoday
Alastar Phelan then spoke about his mathematical modelling approach to enhance signal detection in dual pulse nucleoside labelling experiments for improving cell cycle analysis.
Both speakers showcased their work really well, armed with only a pen and whiteboard!
#qimmunoday
(1/2)
A nice, unique feature of these days is the whiteboard talks.
Michael Schneider went first and gave a nice explanation of how he is augmenting structure enhanced language models by improving MLM with intelligent token masking and space filling curves.
A nice, unique feature of these days is the whiteboard talks.
Michael Schneider went first and gave a nice explanation of how he is augmenting structure enhanced language models by improving MLM with intelligent token masking and space filling curves.
April 10, 2025 at 1:35 PM
(1/2)
A nice, unique feature of these days is the whiteboard talks.
Michael Schneider went first and gave a nice explanation of how he is augmenting structure enhanced language models by improving MLM with intelligent token masking and space filling curves.
A nice, unique feature of these days is the whiteboard talks.
Michael Schneider went first and gave a nice explanation of how he is augmenting structure enhanced language models by improving MLM with intelligent token masking and space filling curves.
(3/3)
Alexis Farman discussed his mathematical models for CAR T cell migration conditions in a microfluidics device, focussing on chemoattractant availability. An interesting tidbit to finish on, where optimisation of receptor affinity was discussed, overlapping nicely with Pietro’s talk.
Alexis Farman discussed his mathematical models for CAR T cell migration conditions in a microfluidics device, focussing on chemoattractant availability. An interesting tidbit to finish on, where optimisation of receptor affinity was discussed, overlapping nicely with Pietro’s talk.
April 10, 2025 at 11:44 AM
(3/3)
Alexis Farman discussed his mathematical models for CAR T cell migration conditions in a microfluidics device, focussing on chemoattractant availability. An interesting tidbit to finish on, where optimisation of receptor affinity was discussed, overlapping nicely with Pietro’s talk.
Alexis Farman discussed his mathematical models for CAR T cell migration conditions in a microfluidics device, focussing on chemoattractant availability. An interesting tidbit to finish on, where optimisation of receptor affinity was discussed, overlapping nicely with Pietro’s talk.