Tauras Vilgalys
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taurvil.bsky.social
Tauras Vilgalys
@taurvil.bsky.social
Postdoc at UChicago. Evolutionary functional genomics, focusing on how humans and other primates respond to infectious disease. Former grad student @EvAnthDuke. 🧪
Many thanks to @jennytung.bsky.social, @afogel29.bsky.social, Jordan Anderson, and all the other members of the @amboselibaboonrp.bsky.social who made this work possible!
August 15, 2025 at 4:23 PM
Together, our results suggest that the genetic architecture of DNA methylation is conserved between closely related species. Cis-genetic effects on gene regulation may remain stable for over a million years, which has implications for how we understand modern and archaic human variants.
August 15, 2025 at 4:23 PM
We also show that ancestry effects within Amboseli recapitulates differences between the parent species. These results support a genetic basis for many interspecific methylation differences, despite environmental variation when individuals are sampled from distinct populations.
August 15, 2025 at 4:23 PM
By changing the allele frequency, admixture introduces new regulatory variation - including at sites that would be otherwise fixed in the population!
August 15, 2025 at 4:23 PM
Local genetic ancestry frequently predicts DNA methylation levels, and these differences can be predicted using the allele frequency at cis-acting genetic variants (meQTL).
August 15, 2025 at 4:23 PM
Thank you!
May 21, 2025 at 5:59 PM
There's some nice work on how the power of selection scans differs based on the time of selection. I can't remember where that figure was published though
May 8, 2025 at 7:22 PM
Wahoo!!
May 7, 2025 at 12:43 AM
Thanks Jun, I couldn't agree more!
May 5, 2025 at 7:55 PM
Thank you!
May 5, 2025 at 7:55 PM
Finally, I am immensely grateful to my mentors over the years (particularly @jennytung.bsky.social and Luis Barreiro), as well as all of the collaborators, lab members, and friends who have helped along this journey!
May 5, 2025 at 4:31 PM
I will be recruiting students, postdocs, and technicians -- if you're interested in this work, please reach out to me!
May 5, 2025 at 4:31 PM
My lab will study how genetic varation among primates shapes the response to environmental stimuli, focusing on the immune system. Ultimately, I hope to connect genetic variation to immune phenotypes and identify the ecological and evolutionary drivers of immune variation.
May 5, 2025 at 4:31 PM