Tatiana Labouré
@tatilab.bsky.social
Structural biology, Membrane proteins, Ion channel
Currently doing my PhD thesis at the Institut de Biologie Structurale, Grenoble, France
Currently doing my PhD thesis at the Institut de Biologie Structurale, Grenoble, France
Reposted by Tatiana Labouré
A fungal-derived compound, ChroB, has an unanticipated mode-of-action (only two were known for GABAA targeting insecticides, since the 1950s) through a site that resembles the neurosteroid mammalian site. And nearby, a new PIP2 site.
March 27, 2025 at 7:51 AM
A fungal-derived compound, ChroB, has an unanticipated mode-of-action (only two were known for GABAA targeting insecticides, since the 1950s) through a site that resembles the neurosteroid mammalian site. And nearby, a new PIP2 site.
Reposted by Tatiana Labouré
Our long term aim is to help develop environmentally benign insecticidal proteins. This mechanistic work is a first big milestone!
March 27, 2025 at 7:51 AM
Our long term aim is to help develop environmentally benign insecticidal proteins. This mechanistic work is a first big milestone!
Reposted by Tatiana Labouré
New preprint! @tatilab.bsky.social imaged the honeybee GABAA RDL receptor. ~10% of insecticides target insect GABAA receptors. She found a new allosteric modulation pocket, a PIP2 site, a closed avermectin-bound conformation, and maybe an unusual desensitized state.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 27, 2025 at 7:51 AM
New preprint! @tatilab.bsky.social imaged the honeybee GABAA RDL receptor. ~10% of insecticides target insect GABAA receptors. She found a new allosteric modulation pocket, a PIP2 site, a closed avermectin-bound conformation, and maybe an unusual desensitized state.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...