@tantoongseng.bsky.social
Research fellow at Ragon Institute of MGB, MIT and Harvard
For free access copy please visit our lab website: ragoninstitute.org/lab/yu/
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Sex differences in HIV-1 reservoir cell selection are linked to altered innate immune profiles
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Sex differences in HIV-1 reservoir cell selection are linked to altered innate immune profiles
December 9, 2025 at 8:09 PM
For free access copy please visit our lab website: ragoninstitute.org/lab/yu/
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Sex differences in HIV-1 reservoir cell selection are linked to altered innate immune profiles
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Sex differences in HIV-1 reservoir cell selection are linked to altered innate immune profiles
Reposted
Pomalidomide enhances CD8+ T and NK cell mediated killing of HIV-infected cells www.thelancet.com/journals/ebi... (open access)
Clinical trial ongoing in people with #HIV: clinicaltrials.gov/study/NCT066...
Clinical trial ongoing in people with #HIV: clinicaltrials.gov/study/NCT066...
Pomalidomide enhances CD8+ T and NK cell mediated killing of HIV-infected cells
Given the immune-enhancing effects and excellent safety profile, pomalidomide should
be further investigated as an immune-enhancing strategy for an HIV cure.
www.thelancet.com
November 14, 2025 at 4:24 PM
Pomalidomide enhances CD8+ T and NK cell mediated killing of HIV-infected cells www.thelancet.com/journals/ebi... (open access)
Clinical trial ongoing in people with #HIV: clinicaltrials.gov/study/NCT066...
Clinical trial ongoing in people with #HIV: clinicaltrials.gov/study/NCT066...
Reposted
Fully-automated spectral unmixing pipeline that reduces error up to 9000-fold @biorxiv-immuno.bsky.social
doi.org/10.1101/2025...
doi.org/10.1101/2025...
October 28, 2025 at 2:52 PM
Fully-automated spectral unmixing pipeline that reduces error up to 9000-fold @biorxiv-immuno.bsky.social
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted
γδ T cells are a unique population of immune cells that can recognize and kill tumors.
A 2024 #ScienceReview explores current research efforts focused on how γδ cells naturally discriminate cancers from healthy tissues. https://scim.ag/3L4i3oU #ScienceMagArchives
A 2024 #ScienceReview explores current research efforts focused on how γδ cells naturally discriminate cancers from healthy tissues. https://scim.ag/3L4i3oU #ScienceMagArchives
Cancer immunotherapy by γδ T cells
The premise of cancer immunotherapy is that cancers are specifically visible to an immune system tolerized to healthy self. The promise of cancer immunotherapy is that immune effector mechanisms and i...
scim.ag
October 24, 2025 at 7:56 PM
γδ T cells are a unique population of immune cells that can recognize and kill tumors.
A 2024 #ScienceReview explores current research efforts focused on how γδ cells naturally discriminate cancers from healthy tissues. https://scim.ag/3L4i3oU #ScienceMagArchives
A 2024 #ScienceReview explores current research efforts focused on how γδ cells naturally discriminate cancers from healthy tissues. https://scim.ag/3L4i3oU #ScienceMagArchives
Reposted
Review @frontiersin.bsky.social Recent advances in feeder-free NK cell expansion as a future direction of adoptive cell therapy
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
October 17, 2025 at 7:43 PM
Review @frontiersin.bsky.social Recent advances in feeder-free NK cell expansion as a future direction of adoptive cell therapy
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
Reposted
Superinfection promotes replication and diversification of defective HIV-1 proviruses in people with non-suppressible viraemia www.nature.com/articles/s41... (open access) #HIV
Superinfection promotes replication and diversification of defective HIV-1 proviruses in people with non-suppressible viraemia - Nature Microbiology
The authors identify defective viral particles, in people with non-suppressible HIV-1, that can replicate through superinfection and interfere with the wild-type virus. However, they show no evidence of these preventing disease progression in the individuals studied.
www.nature.com
October 6, 2025 at 5:56 PM
Superinfection promotes replication and diversification of defective HIV-1 proviruses in people with non-suppressible viraemia www.nature.com/articles/s41... (open access) #HIV
Reposted
Phenotypic and epigenetic profiles of circulating NK cells in spontaneous #HIV controllers www.thelancet.com/journals/ebi... (open access) @ebiomedicine.bsky.social
Phenotypic and epigenetic profiles of circulating NK cells in spontaneous HIV-1 controllers
These results suggest that spontaneous HIV control is associated with an NK cell memory
phenotype, shaped by HIV infection, epigenetic modifications, and genetic factors.
www.thelancet.com
October 1, 2025 at 1:41 PM
Phenotypic and epigenetic profiles of circulating NK cells in spontaneous #HIV controllers www.thelancet.com/journals/ebi... (open access) @ebiomedicine.bsky.social
Reposted
Selective agonists of KIR and NKG2A to evade missing self response of NK cells @daiichisankyo.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 29, 2025 at 8:17 PM
Selective agonists of KIR and NKG2A to evade missing self response of NK cells @daiichisankyo.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
Neuron-reactive KIR+CD8+ T cells display an encephalitogenic transcriptional program in autoimmune encephalitis @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 29, 2025 at 8:21 PM
Neuron-reactive KIR+CD8+ T cells display an encephalitogenic transcriptional program in autoimmune encephalitis @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
CD2 and its ligands, CD48 in mice and CD58 in humans, regulate MAIT cell development and antigen responses by enhancing TCR signaling @jem.org @ircm.bsky.social rupress.org/jem/article-...
October 1, 2025 at 2:47 AM
CD2 and its ligands, CD48 in mice and CD58 in humans, regulate MAIT cell development and antigen responses by enhancing TCR signaling @jem.org @ircm.bsky.social rupress.org/jem/article-...
Reposted
A role for Fas/FasL-Dependent NK-mediated Cytotoxicity in Infants with Perinatal #HIV www.cell.com/iscience/ful... (open access) @cp-iscience.bsky.social
A role for Fas/FasL-Dependent NK-mediated Cytotoxicity in Infants with Perinatal HIV
Perinatal HIV infection occurs during a critical window of immune system development,
yet its impact on innate immune responses in early life remains incompletely understood.
This study examined natur...
www.cell.com
September 26, 2025 at 7:44 PM
A role for Fas/FasL-Dependent NK-mediated Cytotoxicity in Infants with Perinatal #HIV www.cell.com/iscience/ful... (open access) @cp-iscience.bsky.social
Reposted
#HIV infection reprogrammes CD4+ T cells for quiescence and entry into proviral latency www.nature.com/articles/s41... (open access) @natmicrobiol.nature.com
HIV infection reprogrammes CD4+ T cells for quiescence and entry into proviral latency - Nature Microbiology
HIV infection triggers transcriptomic remodelling and a quiescence programme via KLF2 and the p53 pathway leading to proviral silencing.
www.nature.com
September 29, 2025 at 12:38 PM
#HIV infection reprogrammes CD4+ T cells for quiescence and entry into proviral latency www.nature.com/articles/s41... (open access) @natmicrobiol.nature.com
Introducing the Dish Soap Protocol: A Unified Approach for Multi‐Modal Intracellular Staining - Burton - 2025 - Current Protocols - Wiley Online Library currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Introducing the Dish Soap Protocol: A Unified Approach for Multi‐Modal Intracellular Staining
Recent advances in dyes and cytometers have seen an exponential increase in the ability to perform multidimensional flow cytometry. As we increase our capacity to extract information from cells, the ...
currentprotocols.onlinelibrary.wiley.com
September 20, 2025 at 11:28 AM
Introducing the Dish Soap Protocol: A Unified Approach for Multi‐Modal Intracellular Staining - Burton - 2025 - Current Protocols - Wiley Online Library currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Reposted
The role of analytical treatment interruptions in shaping HIV-specific immunity and #HIV cure journals.lww.com/co-hivandaid... (subscription req for full text)
The role of analytical treatment interruptions in shaping... : Current Opinion in HIV and AIDS
act with HIV-specific immune responses is critical for their safe and effective implementation.
Recent findings
Time to rebound ATIs evaluate how quickly HIV returns after stopping treatment and ar...
journals.lww.com
August 21, 2025 at 11:50 AM
The role of analytical treatment interruptions in shaping HIV-specific immunity and #HIV cure journals.lww.com/co-hivandaid... (subscription req for full text)
Reposted
Paper is open access. Previously available in preprint form www.biorxiv.org/content/10.1...
Online now: Transcription factor BACH2 shapes tissue-resident memory T cell programs to promote HIV-1 persistence
Transcription factor BACH2 shapes tissue-resident memory T cell programs to promote HIV-1 persistence
Tissue-resident memory T cells (Trms) are key to mucosal immunity. Wei et al. show that BACH2 restrains Trm effector function to reduce excessive inflammation and promote long-term tissue residence. HIV persists in gut Trm Th17 cells through a BACH2-shaped long-lived memory program, a mechanism of persistence in tissue reservoirs that is distinct from that in the blood.
dlvr.it
August 21, 2025 at 2:54 PM
Paper is open access. Previously available in preprint form www.biorxiv.org/content/10.1...
Reposted
Multi-omics single-cell analysis reveals key regulators of #HIV persistence and aberrant host immune responses in early infection elifesciences.org/articles/104... (open access) @elife.bsky.social
Multi-omics single-cell analysis reveals key regulators of HIV-1 persistence and aberrant host immune responses in early infection
KLF2 activity and impaired interferon signaling contribute to HIV-1 persistence by restricting antiviral immunity in infected CD4 T cells during early infection.
elifesciences.org
August 22, 2025 at 11:06 AM
Multi-omics single-cell analysis reveals key regulators of #HIV persistence and aberrant host immune responses in early infection elifesciences.org/articles/104... (open access) @elife.bsky.social
Reposted
Spatial regulation of CD8+ T cells at the HLA-E-NKG2A axis drives #HIV persistence in lymph node B cell follicles www.cell.com/cell-reports... (open access) @cp-cellreports.bsky.social
Spatial regulation of CD8+ T cells at the HLA-E-NKG2A axis drives HIV persistence in lymph node B cell follicles
Papadopoulos et al. explored spatial compartmentalization of the immune response to
HIV in human lymph nodes, where the virus is known to evade treatment. Novel imaging
and spatial omics uncovered mec...
www.cell.com
August 26, 2025 at 9:51 AM
Spatial regulation of CD8+ T cells at the HLA-E-NKG2A axis drives #HIV persistence in lymph node B cell follicles www.cell.com/cell-reports... (open access) @cp-cellreports.bsky.social
Reposted
High peak viraemia followed by spontaneous #HIV control in women living with HIV-1 subtype A1 in East Africa onlinelibrary.wiley.com/doi/10.1002/... (open access)
<em>Journal of the International AIDS Society</em> | IAS HIV Research Journal | Wiley Online Library
Introduction Cases of spontaneous control of HIV-1 can help define strategies to induce remission. Since the identification of viral control in the absence of treatment typically occurs after a prol...
onlinelibrary.wiley.com
September 3, 2025 at 1:55 PM
High peak viraemia followed by spontaneous #HIV control in women living with HIV-1 subtype A1 in East Africa onlinelibrary.wiley.com/doi/10.1002/... (open access)
Reposted
Estrogen Modulation of B Cell Immunity: Implications for #HIV Control and Therapeutic Strategies onlinelibrary.wiley.com/doi/10.1002/... (open access review)
Estrogen Modulation of B Cell Immunity: Implications for HIV Control and Therapeutic Strategies
Estrogen significantly modulates B-cell immunity. We provide evidence for estrogen–B-cell crosstalk (the estrogen–B-cell axis) in regulating B-cell function and shaping HIV acquisition, progression, ...
onlinelibrary.wiley.com
September 12, 2025 at 8:24 PM
Estrogen Modulation of B Cell Immunity: Implications for #HIV Control and Therapeutic Strategies onlinelibrary.wiley.com/doi/10.1002/... (open access review)
Excited to share our new publication in STM! Our study reveals sex-based differences in how the HIV-1 reservoir is shaped under long-term suppressive ART, with immune responses playing a key role. Put simply: women seem to do better.
#HIVResearch #Immunology #HIVcure
www.science.org/doi/10.1126/...
#HIVResearch #Immunology #HIVcure
www.science.org/doi/10.1126/...
Sex differences in HIV-1 reservoir cell selection are linked to altered innate immune profiles
Sex-specific differences in immune selection of HIV-1 reservoir cells during long-term antiretroviral therapy are driven by innate immunity.
www.science.org
September 19, 2025 at 10:49 AM
Excited to share our new publication in STM! Our study reveals sex-based differences in how the HIV-1 reservoir is shaped under long-term suppressive ART, with immune responses playing a key role. Put simply: women seem to do better.
#HIVResearch #Immunology #HIVcure
www.science.org/doi/10.1126/...
#HIVResearch #Immunology #HIVcure
www.science.org/doi/10.1126/...