Therapeutic Advances in Neurological Disorders
@taneuroldisord.bsky.social
A leading gold #OpenAccess journal in clinical neurology | IF 4.1 CiteScore 8.5 | 🧠 Follow us for neurological research and news.
Ofatumumab is approved for adults with #MultipleSclerosis - but what is its utility in pediatric patients?
Wenlin Wu and colleagues present Case Series data from four pediatric patients:
journals.sagepub.com/doi/full/10....
Wenlin Wu and colleagues present Case Series data from four pediatric patients:
journals.sagepub.com/doi/full/10....
November 27, 2025 at 11:43 AM
Ofatumumab is approved for adults with #MultipleSclerosis - but what is its utility in pediatric patients?
Wenlin Wu and colleagues present Case Series data from four pediatric patients:
journals.sagepub.com/doi/full/10....
Wenlin Wu and colleagues present Case Series data from four pediatric patients:
journals.sagepub.com/doi/full/10....
Can a mobile app facilitate digital documentation and communication in acute #stroke, and improve documentation rates and treatment times?
Stevens and colleagues designed a pilot study to find out:
journals.sagepub.com/doi/full/10....
Stevens and colleagues designed a pilot study to find out:
journals.sagepub.com/doi/full/10....
November 26, 2025 at 3:55 PM
Can a mobile app facilitate digital documentation and communication in acute #stroke, and improve documentation rates and treatment times?
Stevens and colleagues designed a pilot study to find out:
journals.sagepub.com/doi/full/10....
Stevens and colleagues designed a pilot study to find out:
journals.sagepub.com/doi/full/10....
Could brain natriuretic peptide and echocardiographic parameters serve as biomarkers for predicting new atrial fibrillation after acute ischemic stroke?
Stefano Forlivesi and colleagues investigate:
journals.sagepub.com/doi/full/10....
#Stroke #AFib
Stefano Forlivesi and colleagues investigate:
journals.sagepub.com/doi/full/10....
#Stroke #AFib
November 25, 2025 at 3:25 PM
Could brain natriuretic peptide and echocardiographic parameters serve as biomarkers for predicting new atrial fibrillation after acute ischemic stroke?
Stefano Forlivesi and colleagues investigate:
journals.sagepub.com/doi/full/10....
#Stroke #AFib
Stefano Forlivesi and colleagues investigate:
journals.sagepub.com/doi/full/10....
#Stroke #AFib
New from our Special Collection on
Innovative treatments for migraine: a new era
Here, Katsuki and colleagues present trends in real-world use of #lasmiditan for migraine in Japan, using nationwide health insurance claims data.
journals.sagepub.com/doi/full/10....
Innovative treatments for migraine: a new era
Here, Katsuki and colleagues present trends in real-world use of #lasmiditan for migraine in Japan, using nationwide health insurance claims data.
journals.sagepub.com/doi/full/10....
November 24, 2025 at 10:35 AM
New from our Special Collection on
Innovative treatments for migraine: a new era
Here, Katsuki and colleagues present trends in real-world use of #lasmiditan for migraine in Japan, using nationwide health insurance claims data.
journals.sagepub.com/doi/full/10....
Innovative treatments for migraine: a new era
Here, Katsuki and colleagues present trends in real-world use of #lasmiditan for migraine in Japan, using nationwide health insurance claims data.
journals.sagepub.com/doi/full/10....
New #SystematicReview from our Special Collection on Neuromyelitis Optica Spectrum Disorders:
Which environmental risk factors influence the onset of the disease?
Find out more here: journals.sagepub.com/doi/full/10....
Which environmental risk factors influence the onset of the disease?
Find out more here: journals.sagepub.com/doi/full/10....
Environmental risk factors of neuromyelitis optica spectrum disorder: a systematic review - Mahsa Mohammadi Lapevandani, Elham Bazmi, Shima Jahani, Nasrin Asgari, Mohammad Ali Sahraian, 2025
Background: Neuromyelitis optica spectrum disorder (NMOSD) may be triggered by environmental risk factors. Objectives: We aimed to explore and integrate the re...
journals.sagepub.com
November 21, 2025 at 9:49 AM
New #SystematicReview from our Special Collection on Neuromyelitis Optica Spectrum Disorders:
Which environmental risk factors influence the onset of the disease?
Find out more here: journals.sagepub.com/doi/full/10....
Which environmental risk factors influence the onset of the disease?
Find out more here: journals.sagepub.com/doi/full/10....
Posterior circulation stroke: What predicts recovery after thrombectomy?
Post hoc analysis of 353 patients shows 24-h NIHSS ≤9 is the strongest predictor of favorable 90-day mRS.
ΔNIHSS and % change less reliable. #Stroke journals.sagepub.com/doi/full/10....
Post hoc analysis of 353 patients shows 24-h NIHSS ≤9 is the strongest predictor of favorable 90-day mRS.
ΔNIHSS and % change less reliable. #Stroke journals.sagepub.com/doi/full/10....
November 20, 2025 at 10:23 AM
Posterior circulation stroke: What predicts recovery after thrombectomy?
Post hoc analysis of 353 patients shows 24-h NIHSS ≤9 is the strongest predictor of favorable 90-day mRS.
ΔNIHSS and % change less reliable. #Stroke journals.sagepub.com/doi/full/10....
Post hoc analysis of 353 patients shows 24-h NIHSS ≤9 is the strongest predictor of favorable 90-day mRS.
ΔNIHSS and % change less reliable. #Stroke journals.sagepub.com/doi/full/10....
New Case Series online:
#Migraine with brainstem aura with abnormal EEG discharges easily misdiagnosed as epilepsy
journals.sagepub.com/doi/full/10....
#Migraine with brainstem aura with abnormal EEG discharges easily misdiagnosed as epilepsy
journals.sagepub.com/doi/full/10....
November 19, 2025 at 9:30 AM
New Case Series online:
#Migraine with brainstem aura with abnormal EEG discharges easily misdiagnosed as epilepsy
journals.sagepub.com/doi/full/10....
#Migraine with brainstem aura with abnormal EEG discharges easily misdiagnosed as epilepsy
journals.sagepub.com/doi/full/10....
New article in our Special Collection: New Frontiers in Acute Reperfusion Therapies for Acute Ischemic Stroke
This Review synthesizes evidence for the effectiveness of "Drip & Ship" model in acute #stroke care: 🚑
journals.sagepub.com/doi/full/10....
This Review synthesizes evidence for the effectiveness of "Drip & Ship" model in acute #stroke care: 🚑
journals.sagepub.com/doi/full/10....
November 18, 2025 at 9:53 AM
New article in our Special Collection: New Frontiers in Acute Reperfusion Therapies for Acute Ischemic Stroke
This Review synthesizes evidence for the effectiveness of "Drip & Ship" model in acute #stroke care: 🚑
journals.sagepub.com/doi/full/10....
This Review synthesizes evidence for the effectiveness of "Drip & Ship" model in acute #stroke care: 🚑
journals.sagepub.com/doi/full/10....
Could #MultipleSclerosis phenotypic profiles be distinguishable at diagnosis?
Aurora Zanghi and colleagues use a multimodal #biomarker approach to investigate:
journals.sagepub.com/doi/full/10....
Aurora Zanghi and colleagues use a multimodal #biomarker approach to investigate:
journals.sagepub.com/doi/full/10....
November 14, 2025 at 12:14 PM
Could #MultipleSclerosis phenotypic profiles be distinguishable at diagnosis?
Aurora Zanghi and colleagues use a multimodal #biomarker approach to investigate:
journals.sagepub.com/doi/full/10....
Aurora Zanghi and colleagues use a multimodal #biomarker approach to investigate:
journals.sagepub.com/doi/full/10....
Is increased middle cerebral artery peak systolic velocity associated with the development of malignant media infarction after endovascular thrombectomy?
Find out more in this study, recently published in Therapeutic Advances in Neurological Disorders: #stroke
journals.sagepub.com/doi/full/10....
Find out more in this study, recently published in Therapeutic Advances in Neurological Disorders: #stroke
journals.sagepub.com/doi/full/10....
November 13, 2025 at 9:29 AM
Is increased middle cerebral artery peak systolic velocity associated with the development of malignant media infarction after endovascular thrombectomy?
Find out more in this study, recently published in Therapeutic Advances in Neurological Disorders: #stroke
journals.sagepub.com/doi/full/10....
Find out more in this study, recently published in Therapeutic Advances in Neurological Disorders: #stroke
journals.sagepub.com/doi/full/10....
A new RCT online!
Lisa Schäfer and colleagues show how multidisciplinary online care can improve mental health, vitality, and quality of life in women with X-linked adrenoleukodystrophy - a model that could be scaled for other rare disorders.
#RareDisease
journals.sagepub.com/doi/pdf/10.1...
Lisa Schäfer and colleagues show how multidisciplinary online care can improve mental health, vitality, and quality of life in women with X-linked adrenoleukodystrophy - a model that could be scaled for other rare disorders.
#RareDisease
journals.sagepub.com/doi/pdf/10.1...
November 12, 2025 at 10:29 AM
A new RCT online!
Lisa Schäfer and colleagues show how multidisciplinary online care can improve mental health, vitality, and quality of life in women with X-linked adrenoleukodystrophy - a model that could be scaled for other rare disorders.
#RareDisease
journals.sagepub.com/doi/pdf/10.1...
Lisa Schäfer and colleagues show how multidisciplinary online care can improve mental health, vitality, and quality of life in women with X-linked adrenoleukodystrophy - a model that could be scaled for other rare disorders.
#RareDisease
journals.sagepub.com/doi/pdf/10.1...
New study by Matteo Foschi et al reveals sex-specific patterns in #MultipleSclerosis progression:
Women—especially postmenopausal—face higher risk of disability worsening independent of relapses, while men experience greater impact per event:
journals.sagepub.com/doi/full/10....
Women—especially postmenopausal—face higher risk of disability worsening independent of relapses, while men experience greater impact per event:
journals.sagepub.com/doi/full/10....
November 11, 2025 at 10:09 AM
New study by Matteo Foschi et al reveals sex-specific patterns in #MultipleSclerosis progression:
Women—especially postmenopausal—face higher risk of disability worsening independent of relapses, while men experience greater impact per event:
journals.sagepub.com/doi/full/10....
Women—especially postmenopausal—face higher risk of disability worsening independent of relapses, while men experience greater impact per event:
journals.sagepub.com/doi/full/10....
New Review online!
Here, Joost Smolders and colleagues argue that aggressive treatment of early acute focal inflammatory activity in #MultipleSclerosis can extend the window for BTK inhibition and slow down progression
journals.sagepub.com/doi/full/10....
Here, Joost Smolders and colleagues argue that aggressive treatment of early acute focal inflammatory activity in #MultipleSclerosis can extend the window for BTK inhibition and slow down progression
journals.sagepub.com/doi/full/10....
November 10, 2025 at 4:03 PM
New Review online!
Here, Joost Smolders and colleagues argue that aggressive treatment of early acute focal inflammatory activity in #MultipleSclerosis can extend the window for BTK inhibition and slow down progression
journals.sagepub.com/doi/full/10....
Here, Joost Smolders and colleagues argue that aggressive treatment of early acute focal inflammatory activity in #MultipleSclerosis can extend the window for BTK inhibition and slow down progression
journals.sagepub.com/doi/full/10....
New Review online!
Here, Wolfgang Jost and Jiri Koschel discuss approaches for diagnosing and treating cardiovascular symptoms in #Parkinson’s disease:
journals.sagepub.com/doi/full/10....
Here, Wolfgang Jost and Jiri Koschel discuss approaches for diagnosing and treating cardiovascular symptoms in #Parkinson’s disease:
journals.sagepub.com/doi/full/10....
November 6, 2025 at 10:42 AM
New Review online!
Here, Wolfgang Jost and Jiri Koschel discuss approaches for diagnosing and treating cardiovascular symptoms in #Parkinson’s disease:
journals.sagepub.com/doi/full/10....
Here, Wolfgang Jost and Jiri Koschel discuss approaches for diagnosing and treating cardiovascular symptoms in #Parkinson’s disease:
journals.sagepub.com/doi/full/10....
🧠 20 years of #natalizumab in #MultipleSclerosis care:
A new Review reflects on two decades of clinical experience with natalizumab—its efficacy, safety, and evolving role in treatment strategies.
📖 Read this Open Access article here: doi.org/10.1177/1756...
A new Review reflects on two decades of clinical experience with natalizumab—its efficacy, safety, and evolving role in treatment strategies.
📖 Read this Open Access article here: doi.org/10.1177/1756...
November 5, 2025 at 11:18 AM
🧠 20 years of #natalizumab in #MultipleSclerosis care:
A new Review reflects on two decades of clinical experience with natalizumab—its efficacy, safety, and evolving role in treatment strategies.
📖 Read this Open Access article here: doi.org/10.1177/1756...
A new Review reflects on two decades of clinical experience with natalizumab—its efficacy, safety, and evolving role in treatment strategies.
📖 Read this Open Access article here: doi.org/10.1177/1756...
Elevated liver enzymes (AST, ALT, GGT) may correlate with lower #migraine prevalence—especially migraines without aura.
Could glutamate regulation be a metabolic clue in migraine pathology?
New study by Angela Ruban and colleagues:
journals.sagepub.com/doi/full/10....
Could glutamate regulation be a metabolic clue in migraine pathology?
New study by Angela Ruban and colleagues:
journals.sagepub.com/doi/full/10....
November 4, 2025 at 11:33 AM
Elevated liver enzymes (AST, ALT, GGT) may correlate with lower #migraine prevalence—especially migraines without aura.
Could glutamate regulation be a metabolic clue in migraine pathology?
New study by Angela Ruban and colleagues:
journals.sagepub.com/doi/full/10....
Could glutamate regulation be a metabolic clue in migraine pathology?
New study by Angela Ruban and colleagues:
journals.sagepub.com/doi/full/10....
Could GLP-1 receptor agonists affect Parkinson’s disease progression?
Check out this recent meta-analysis by Tsai et al:
journals.sagepub.com/doi/full/10....
Check out this recent meta-analysis by Tsai et al:
journals.sagepub.com/doi/full/10....
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October 24, 2025 at 11:57 AM
Could GLP-1 receptor agonists affect Parkinson’s disease progression?
Check out this recent meta-analysis by Tsai et al:
journals.sagepub.com/doi/full/10....
Check out this recent meta-analysis by Tsai et al:
journals.sagepub.com/doi/full/10....
Which imaging and soluble #biomarkers best predict progression from relapsing-remitting #MultipleSclerosis to secondary progressive MS?
Sini Laaksonen & colleagues investigate: journals.sagepub.com/doi/full/10....
Sini Laaksonen & colleagues investigate: journals.sagepub.com/doi/full/10....
October 22, 2025 at 3:13 PM
Which imaging and soluble #biomarkers best predict progression from relapsing-remitting #MultipleSclerosis to secondary progressive MS?
Sini Laaksonen & colleagues investigate: journals.sagepub.com/doi/full/10....
Sini Laaksonen & colleagues investigate: journals.sagepub.com/doi/full/10....
In #ALS, analysis of 636 patients (2013–2023) found racial and ethnic disparities in care: Non-Hispanic Black patients had higher tracheostomy rates, and Hispanic patients were less likely to receive riluzole. Survival was similar across groups.
🔗 journals.sagepub.com/doi/epdf/10....
🔗 journals.sagepub.com/doi/epdf/10....
October 10, 2025 at 4:11 PM
In #ALS, analysis of 636 patients (2013–2023) found racial and ethnic disparities in care: Non-Hispanic Black patients had higher tracheostomy rates, and Hispanic patients were less likely to receive riluzole. Survival was similar across groups.
🔗 journals.sagepub.com/doi/epdf/10....
🔗 journals.sagepub.com/doi/epdf/10....
In rescue stenting after failed thrombectomy, dual antiplatelet therapy post-procedure improved outcomes and reduced mortality and stent occlusion vs single therapy. Most occlusions occurred within 24 h, underscoring early management importance.
🔗 journals.sagepub.com/doi/epdf/10....
🔗 journals.sagepub.com/doi/epdf/10....
October 10, 2025 at 4:09 PM
In rescue stenting after failed thrombectomy, dual antiplatelet therapy post-procedure improved outcomes and reduced mortality and stent occlusion vs single therapy. Most occlusions occurred within 24 h, underscoring early management importance.
🔗 journals.sagepub.com/doi/epdf/10....
🔗 journals.sagepub.com/doi/epdf/10....
In #ParkinsonsDisease, orthostatic hypotension (OH) is a disabling feature linked to poor quality of life and fall risk. This review summarizes pharmacologic and nonpharmacologic strategies for managing OH in PD.
🔗 journals.sagepub.com/doi/epdf/10....
🔗 journals.sagepub.com/doi/epdf/10....
October 10, 2025 at 4:08 PM
In #ParkinsonsDisease, orthostatic hypotension (OH) is a disabling feature linked to poor quality of life and fall risk. This review summarizes pharmacologic and nonpharmacologic strategies for managing OH in PD.
🔗 journals.sagepub.com/doi/epdf/10....
🔗 journals.sagepub.com/doi/epdf/10....
Case series: #Levodopa–carbidopa intestinal gel (LCIG) reduced “off” time & dyskinesia in young-onset #MSA-P patients with preserved levodopa response. While ADLs declined with progression, LCIG may offer benefit for selected cases.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
October 3, 2025 at 3:10 PM
Case series: #Levodopa–carbidopa intestinal gel (LCIG) reduced “off” time & dyskinesia in young-onset #MSA-P patients with preserved levodopa response. While ADLs declined with progression, LCIG may offer benefit for selected cases.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
🧪 Long-term study of #Cladribine in #MultipleSclerosis shows no loss of humoral immunity after up to 7 years. Patients maintained protective IgG to common pathogens & mounted new responses (e.g. SARS-CoV-2). Supports strong long-term safety profile.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
October 3, 2025 at 3:09 PM
🧪 Long-term study of #Cladribine in #MultipleSclerosis shows no loss of humoral immunity after up to 7 years. Patients maintained protective IgG to common pathogens & mounted new responses (e.g. SARS-CoV-2). Supports strong long-term safety profile.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
New national guidelines for #MyastheniaGravis in Israel standardize diagnosis & treatment. They integrate antibody testing, imaging, thymectomy recommendations, & tailored immunotherapy to improve outcomes & reduce care disparities.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
October 3, 2025 at 3:08 PM
New national guidelines for #MyastheniaGravis in Israel standardize diagnosis & treatment. They integrate antibody testing, imaging, thymectomy recommendations, & tailored immunotherapy to improve outcomes & reduce care disparities.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
Review: immune tolerance in #NMOSD/#MOGAD as an alternative to long-term immunosuppression. Strategies include antigen-specific vaccines/nanoparticles, Treg/Breg cell therapy, and gene editing. Aim: durable remission with fewer systemic effects.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
September 26, 2025 at 3:29 PM
Review: immune tolerance in #NMOSD/#MOGAD as an alternative to long-term immunosuppression. Strategies include antigen-specific vaccines/nanoparticles, Treg/Breg cell therapy, and gene editing. Aim: durable remission with fewer systemic effects.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....