Takaki Komiyama
@takakikomiyama.bsky.social
UCSD professor of neurobiology and neurosciences
Reposted by Takaki Komiyama
Will you be at #SfN25? Don’t miss these lectures:
📍Sun 11/16 3pm: The Neural Code of Speech (Edward Chang, KIFN)
📍Mon 11/17 10:30am: Motor Cortex Circuits for Learned Movements (Takaki Komiyama, KIBM)
📍Tue 11/18 5:30pm: Neuronal Aging & Cognitive Decline (Rusty Gage, KIBM)
#KavliNeuro
📍Sun 11/16 3pm: The Neural Code of Speech (Edward Chang, KIFN)
📍Mon 11/17 10:30am: Motor Cortex Circuits for Learned Movements (Takaki Komiyama, KIBM)
📍Tue 11/18 5:30pm: Neuronal Aging & Cognitive Decline (Rusty Gage, KIBM)
#KavliNeuro
November 14, 2025 at 2:56 AM
Will you be at #SfN25? Don’t miss these lectures:
📍Sun 11/16 3pm: The Neural Code of Speech (Edward Chang, KIFN)
📍Mon 11/17 10:30am: Motor Cortex Circuits for Learned Movements (Takaki Komiyama, KIBM)
📍Tue 11/18 5:30pm: Neuronal Aging & Cognitive Decline (Rusty Gage, KIBM)
#KavliNeuro
📍Sun 11/16 3pm: The Neural Code of Speech (Edward Chang, KIFN)
📍Mon 11/17 10:30am: Motor Cortex Circuits for Learned Movements (Takaki Komiyama, KIBM)
📍Tue 11/18 5:30pm: Neuronal Aging & Cognitive Decline (Rusty Gage, KIBM)
#KavliNeuro
A mythical unicorn god on the baseball field
October 18, 2025 at 6:37 AM
A mythical unicorn god on the baseball field
Reposted by Takaki Komiyama
A new @nature.com study from Simons Collaboration on the Global Brain investigator @takakikomiyama.bsky.social finds that as mice learn a complex movement, the pathway from the motor thalamus to the motor cortex rewires itself to drive the movement: www.simonsfoundation.org/2025/08/11/h... #science
How a Tiny Brain Region Helps You Learn Complex Movements, One Neuron at a Time
How a Tiny Brain Region Helps You Learn Complex Movements, One Neuron at a Time on Simons Foundation
www.simonsfoundation.org
August 12, 2025 at 4:25 PM
A new @nature.com study from Simons Collaboration on the Global Brain investigator @takakikomiyama.bsky.social finds that as mice learn a complex movement, the pathway from the motor thalamus to the motor cortex rewires itself to drive the movement: www.simonsfoundation.org/2025/08/11/h... #science
Our new paper is out in Science.
We identified a subgroup of cholinergic neurons that mediate sensory modality-specific attention. They change their funcitonal properties within secs of behavioral context change.
Congrats to Bin for the great thesis, and the team!
www.science.org/doi/10.1126/...
We identified a subgroup of cholinergic neurons that mediate sensory modality-specific attention. They change their funcitonal properties within secs of behavioral context change.
Congrats to Bin for the great thesis, and the team!
www.science.org/doi/10.1126/...
Cholinergic feedback for modality- and context-specific modulation of sensory representations
The brain’s ability to prioritize sensory information is crucial for adaptive behavior, yet its mechanisms remain unclear. We investigated basal forebrain cholinergic neurons modulating olfactory bulb...
www.science.org
June 20, 2025 at 3:32 PM
Our new paper is out in Science.
We identified a subgroup of cholinergic neurons that mediate sensory modality-specific attention. They change their funcitonal properties within secs of behavioral context change.
Congrats to Bin for the great thesis, and the team!
www.science.org/doi/10.1126/...
We identified a subgroup of cholinergic neurons that mediate sensory modality-specific attention. They change their funcitonal properties within secs of behavioral context change.
Congrats to Bin for the great thesis, and the team!
www.science.org/doi/10.1126/...
In June 2001, I arrived in SFO with a suitcase, a student visa, and disproportionate dreams.
My life since has been nothing but a dream.
My heart is with the international students in the US today.
My life since has been nothing but a dream.
My heart is with the international students in the US today.
May 23, 2025 at 2:47 PM
In June 2001, I arrived in SFO with a suitcase, a student visa, and disproportionate dreams.
My life since has been nothing but a dream.
My heart is with the international students in the US today.
My life since has been nothing but a dream.
My heart is with the international students in the US today.
Our paper is out in Nature.
By examining various inputs to the motor cortex during learning, we found that thalamic inputs learn to activate the cortical neurons encoding the movement being learned.
Tour de force by Assaf in collab with Felix and Marcus. Congrats!
www.nature.com/articles/s41...
By examining various inputs to the motor cortex during learning, we found that thalamic inputs learn to activate the cortical neurons encoding the movement being learned.
Tour de force by Assaf in collab with Felix and Marcus. Congrats!
www.nature.com/articles/s41...
Motor learning refines thalamic influence on motor cortex - Nature
Imaging and optogenetics in mice provide insight into the interplay between the primary motor cortex and the motor thalamus during learning, showing that thalamic inputs have a key role in the executi...
www.nature.com
May 8, 2025 at 12:12 AM
Our paper is out in Nature.
By examining various inputs to the motor cortex during learning, we found that thalamic inputs learn to activate the cortical neurons encoding the movement being learned.
Tour de force by Assaf in collab with Felix and Marcus. Congrats!
www.nature.com/articles/s41...
By examining various inputs to the motor cortex during learning, we found that thalamic inputs learn to activate the cortical neurons encoding the movement being learned.
Tour de force by Assaf in collab with Felix and Marcus. Congrats!
www.nature.com/articles/s41...
A very thoughtful Perspective on our recent paper by Ayelén Groisman and Johannes Letzkus. Thank you!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Dendritic arbors structure memories
Synapses on different dendritic domains store distinct types of information
www.science.org
April 21, 2025 at 9:53 PM
A very thoughtful Perspective on our recent paper by Ayelén Groisman and Johannes Letzkus. Thank you!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Our new paper is out in Science.
What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.
Congrats Jake!
www.science.org/doi/10.1126/...
What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.
Congrats Jake!
www.science.org/doi/10.1126/...
Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning
Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of plasti...
www.science.org
April 17, 2025 at 11:46 PM
Our new paper is out in Science.
What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.
Congrats Jake!
www.science.org/doi/10.1126/...
What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.
Congrats Jake!
www.science.org/doi/10.1126/...
Reposted by Takaki Komiyama
How do different cortical neuron types contribute to circuit dysfunction in #Huntington’s disease?
Check out our new collaborative study with @takakikomiyama.bsky.social, spearheaded by Sonja Blumenstock, now out as a preprint.
www.biorxiv.org/content/10.1...
Check out our new collaborative study with @takakikomiyama.bsky.social, spearheaded by Sonja Blumenstock, now out as a preprint.
www.biorxiv.org/content/10.1...
Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington′s Disease mice
Huntington′s disease (HD) is a devastating movement disorder without a current cure. Although the monogenic basis of HD is well-defined, the complex downstream effects that underlie behavioral symptom...
www.biorxiv.org
February 9, 2025 at 1:04 PM
How do different cortical neuron types contribute to circuit dysfunction in #Huntington’s disease?
Check out our new collaborative study with @takakikomiyama.bsky.social, spearheaded by Sonja Blumenstock, now out as a preprint.
www.biorxiv.org/content/10.1...
Check out our new collaborative study with @takakikomiyama.bsky.social, spearheaded by Sonja Blumenstock, now out as a preprint.
www.biorxiv.org/content/10.1...
Our new paper shows that targeted stimulation of a subtype of cortical inhibitory neurons can ameliorate motor deficits in Huntington’s disease mice. A great collab with @irinadudanova.bsky.social www.biorxiv.org/content/10.1...
Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington′s Disease mice
Huntington′s disease (HD) is a devastating movement disorder without a current cure. Although the monogenic basis of HD is well-defined, the complex downstream effects that underlie behavioral symptom...
www.biorxiv.org
February 10, 2025 at 5:41 AM
Our new paper shows that targeted stimulation of a subtype of cortical inhibitory neurons can ameliorate motor deficits in Huntington’s disease mice. A great collab with @irinadudanova.bsky.social www.biorxiv.org/content/10.1...
663 days since the senseless tragedy that took An, we present a manuscript that reports some of the discoveries that she left us.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Targeted stimulation of motor cortex neural ensembles drives learned movements
During the execution of learned motor skills, the neural population in the layer 2/3 (L2/3) of the primary motor cortex (M1) expresses a reproducible spatiotemporal activity pattern. It is debated whe...
www.biorxiv.org
January 7, 2025 at 5:53 AM
663 days since the senseless tragedy that took An, we present a manuscript that reports some of the discoveries that she left us.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
IMO one of the most exciting studies I’ve seen recently. Trial-level unmasking of memory-specific functional connectivity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Intermittent rate coding and cue-specific ensembles support working memory - Nature
By recording large populations of neurons in behaving monkeys using newly developed silicon probes, we show that intermittent periods of memorandum-specific spiking coexist with synaptic mechanis...
www.nature.com
December 20, 2024 at 12:33 AM
IMO one of the most exciting studies I’ve seen recently. Trial-level unmasking of memory-specific functional connectivity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our new paper out in Science Advances. A population code in the retrosplenial cortex explains the discrepancy between animal behavior and standard RL models. www.science.org/doi/10.1126/...
November 29, 2023 at 8:17 PM
Our new paper out in Science Advances. A population code in the retrosplenial cortex explains the discrepancy between animal behavior and standard RL models. www.science.org/doi/10.1126/...
Our new paper out in @NatureNeuro. We uncovered the roles of orbitofrontal cortex in distinct aspects of meta-reinforcement learning. www.nature.com/articles/s41...
Meta-reinforcement learning via orbitofrontal cortex - Nature Neuroscience
The authors show that neural activity and synaptic plasticity in the orbitofrontal cortex mediate multiple timescales of reinforcement learning (RL) for meta-RL, which parallels a form of meta-RL in a...
www.nature.com
November 14, 2023 at 9:15 PM
Our new paper out in @NatureNeuro. We uncovered the roles of orbitofrontal cortex in distinct aspects of meta-reinforcement learning. www.nature.com/articles/s41...
PSA to SfN attendees— the metro now goes between Dulles and downtown DC
November 11, 2023 at 2:32 PM
PSA to SfN attendees— the metro now goes between Dulles and downtown DC
Our recent collab paper. Reanalysis of our previous data from a functional connectome perspective identified hub neurons that remain the center of functional reorganization during learning. Congrats Saber, Rudi et al.!
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Rewiring Dynamics of Functional Connectomes during Motor-Skill Learning
The brain’s functional connectome continually rewires throughout an organism’s life. In this study, we sought to elucidate the operational principles of such rewiring in mouse primary motor cortex...
www.tandfonline.com
November 8, 2023 at 11:10 PM
Our recent collab paper. Reanalysis of our previous data from a functional connectome perspective identified hub neurons that remain the center of functional reorganization during learning. Congrats Saber, Rudi et al.!
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Excited to be speaking at this SfN satellite meeting on Saturday evening
mbns.bruker.com/acton/fs/blo...
mbns.bruker.com/acton/fs/blo...
mbns.bruker.com
November 8, 2023 at 11:05 PM
Excited to be speaking at this SfN satellite meeting on Saturday evening
mbns.bruker.com/acton/fs/blo...
mbns.bruker.com/acton/fs/blo...
Wrote a little intro to the BICCN package that just dropped: www.science.org/doi/full/10....
Science | AAAS
www.science.org
October 13, 2023 at 7:01 AM
Wrote a little intro to the BICCN package that just dropped: www.science.org/doi/full/10....
Our recent collab paper-- an attempt at spike estimation from calcium imaging data with temporal superresolution (i.e. faster than the frame rate), congrats to Pulak and Piya: ieeexplore.ieee.org/abstract/doc...
October 12, 2023 at 6:59 AM
Our recent collab paper-- an attempt at spike estimation from calcium imaging data with temporal superresolution (i.e. faster than the frame rate), congrats to Pulak and Piya: ieeexplore.ieee.org/abstract/doc...
Please smack me if I become a billionaire and start acting like Elon Musk.
October 6, 2023 at 5:49 PM
Please smack me if I become a billionaire and start acting like Elon Musk.