Tabea Elsener
@tabeaelsener.bsky.social
DPhil candidate at the Sir William Dunn School of Pathology, University of Oxford. I love chasing resistance plasmids through the gonococcal population, reading old research papers and making microbiology experiments edible with sourdough baking =)
I am already excited for my next scientific adventure 🌟 @pasteur.fr @epcrocha.bsky.social
September 21, 2025 at 7:01 AM
I am already excited for my next scientific adventure 🌟 @pasteur.fr @epcrocha.bsky.social
Many thanks also to my assessors @jpjhall.bsky.social and Prof Craig McLean for the thought-provoking discussions during my viva!
September 21, 2025 at 6:58 AM
Many thanks also to my assessors @jpjhall.bsky.social and Prof Craig McLean for the thought-provoking discussions during my viva!
February 27, 2025 at 12:23 PM
February 27, 2025 at 12:20 PM
pbla is mobilised by the conjugative plasmid pConj, which can harbour a tetracycline resistance marker that confers doxycycline resistance. Due to the close relationship between pbla and pConj, widespread use of Doxy-PEP is likely to promote the spread of both pConj and pbla.
January 8, 2025 at 10:02 AM
pbla is mobilised by the conjugative plasmid pConj, which can harbour a tetracycline resistance marker that confers doxycycline resistance. Due to the close relationship between pbla and pConj, widespread use of Doxy-PEP is likely to promote the spread of both pConj and pbla.
In particular, TEM-135, which has arisen in certain pbla variants, increases resistance to beta-lactams and only requires one amino acid change to become an extended spectrum beta-lactamase.
January 8, 2025 at 9:59 AM
In particular, TEM-135, which has arisen in certain pbla variants, increases resistance to beta-lactams and only requires one amino acid change to become an extended spectrum beta-lactamase.
Subsequently, different evolutionary pathways were taken by three major pbla variants. Changes that mitigate fitness costs of pbla and the emergence of TEM beta-lactamases which confer increased resistance have contributed to the success of pbla.
January 8, 2025 at 9:58 AM
Subsequently, different evolutionary pathways were taken by three major pbla variants. Changes that mitigate fitness costs of pbla and the emergence of TEM beta-lactamases which confer increased resistance have contributed to the success of pbla.
We investigated the origin and evolution of pbla and demonstrate that the plasmid was acquired on at least two occasions from Haemophilus ducreyi.
January 8, 2025 at 9:57 AM
We investigated the origin and evolution of pbla and demonstrate that the plasmid was acquired on at least two occasions from Haemophilus ducreyi.
Where does the gonococcal beta-lactamase plasmid pbla come from and how does its interaction with the conjugative plasmid pConj, fitness costs and resistance levels determine its spread in the population? And what are the implications for current treatment and prevention strategies such as Doxy-PEP?
January 8, 2025 at 9:55 AM
Where does the gonococcal beta-lactamase plasmid pbla come from and how does its interaction with the conjugative plasmid pConj, fitness costs and resistance levels determine its spread in the population? And what are the implications for current treatment and prevention strategies such as Doxy-PEP?
Absolutely! I finally made it to the bright side and will announce the preprint here as well.
Thanks! I'm looking forward to hearing your thoughts on it!
Thanks! I'm looking forward to hearing your thoughts on it!
January 8, 2025 at 9:16 AM
Absolutely! I finally made it to the bright side and will announce the preprint here as well.
Thanks! I'm looking forward to hearing your thoughts on it!
Thanks! I'm looking forward to hearing your thoughts on it!