Great reunion of COVID gangsters in my lab!! Welcome back, Ralph🇺🇸 and Angie🇨🇦😎

Also thanks for coming, Yvonne🇸🇬, Peter🇸🇬 and Daniel🇦🇺🍷🦇‼️

We demonstrated that SARS-CoV-2 JN.1 recombinant protein vaccine induces the neutralizing antibodies effective not only against JN.1 but also against a variety of variants including XEC. 2/2

Here is the Sato Lab, 2025😎!
🇨🇳🇯🇵🇨🇳🇯🇵🇯🇵🇯🇵🇯🇵🇰🇷🇯🇵🇯🇵🇯🇵🇨🇳🇬🇷🇯🇵🇯🇵🇯🇵🇯🇵🇹🇭🇨🇭🇹🇭🇯🇵🇯🇵🇹🇭🇯🇵🇯🇵🇵🇭🇯🇵🇯🇵🇯🇵🇮🇩🇯🇵🇨🇳🇨🇳

What a shame. I am just taking about the possibility for scientific collaboration with US scientists. Why the conspiracy theory people in X simplistically talk about “GOF” experiments? I have never talked about such topics before.

Second, the antiviral immunity induced by XBB.1.5 vaccine against B.1.1 was greater than that against XBB.1.5, and the difference between these two variants was ~4-fold. But the difference in JN.1 vaccine-induced immunity between B.1.1 and XBB.1.5 was <1.5-fold.
Again, why🤔? 5/

But there are two scientific interests.

First, compared to our recent study using JN.1 and KP.3.3 breakthrough (i.e. natural) infection sera, antiviral humoral immunity against KP.3 and XEC was weakly induced. However, JN.1 mNRA vaccine can. Why🤔?? 3/

In this study, we used 2 mRNA vaccines, one is from Pfizer/BioNTech🇺🇸🇩🇪, while another is from Daiichi-Sankyo🇯🇵. The good news is that there are no significant differences between them and both broadly neutralized a variety of SARS-CoV-2 including JN.1, KP.3.1.1 and XEC. 2/

In the coming days, our international #CSHApandemic meeting, organized by Cold Spring Harbor Asia, will finally kick off in Awaji, Japan🇯🇵 Super excited and honored to be the local organizer of this fantastic meeting. Looking forward to seeing great COVID scientists😆‼️