Suzanne Pfeffer
Suzanne Pfeffer
@suzannepfeffer.bsky.social
Professor at Stanford University School of Medicine Department of Biochemistry studying the molecular basis of Parkisnon's as part of the Aligning Science Across Parkinsons research program
Excited to share our preprint showing loss of Hedgehog signaling in GBA1 mutant cells, converging with LRRK2 mutant phenotypes biorxiv.org/content/earl...
@asapresearch.bsky.social
Lysosomal Glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway to Parkinsons disease
Mutations in LRRK2 and GBA1 are the most common genetic causes of familial Parkinsons disease. Previously, we showed that pathogenic LRRK2 mutations inhibit primary cilia formation in rare interneuron...
biorxiv.org
January 21, 2025 at 7:22 PM
Excited to share our recent paper: [Parkinson's linked] Pathogenic LRRK2 mutations cause loss of primary cilia and Neurturin in striatal parvalbumin (PV) interneurons" in mouse and human. DOI 10.26508/lsa.202402922 #Parkinsons @asapresearch.bsky.social @scienceofpd.bsky.social
November 13, 2024 at 7:27 PM