Jotham Suez (SuezLab@JHU)
@suez.bsky.social
Microbiome enthusiast 🦠 || Assistant Professor for Molecular Microbiology and Immunology at Johns Hopkins University || He/Him 🏳️🌈🏳️⚧️
www.suezlab.org
www.suezlab.org
Really cool work, congrats!
Curious what this would say about our Cell 2018 data with humans taking antibiotics & probiotics 🙂
Curious what this would say about our Cell 2018 data with humans taking antibiotics & probiotics 🙂
July 31, 2025 at 5:45 PM
Really cool work, congrats!
Curious what this would say about our Cell 2018 data with humans taking antibiotics & probiotics 🙂
Curious what this would say about our Cell 2018 data with humans taking antibiotics & probiotics 🙂
We need more studies causally linking sucralose-altered human microbiomes to immunotherapy efficacy to guide clinical decision-making.
But there are already good reasons to consider reducing the intake of artificial sweeteners (and sugar!).
Congrats on an important and interesting work!
fin/🧵
But there are already good reasons to consider reducing the intake of artificial sweeteners (and sugar!).
Congrats on an important and interesting work!
fin/🧵
July 31, 2025 at 5:24 PM
We need more studies causally linking sucralose-altered human microbiomes to immunotherapy efficacy to guide clinical decision-making.
But there are already good reasons to consider reducing the intake of artificial sweeteners (and sugar!).
Congrats on an important and interesting work!
fin/🧵
But there are already good reasons to consider reducing the intake of artificial sweeteners (and sugar!).
Congrats on an important and interesting work!
fin/🧵
Their data in humans are observational and extend to other non-nutritive sweeteners as well. These observations are supported by extensive preclinical work, including microbiome transplants to establish a causal role for the sucralose-altered microbiome in disrupting cancer immunotherapy.
3/🧵
3/🧵
July 31, 2025 at 5:24 PM
Their data in humans are observational and extend to other non-nutritive sweeteners as well. These observations are supported by extensive preclinical work, including microbiome transplants to establish a causal role for the sucralose-altered microbiome in disrupting cancer immunotherapy.
3/🧵
3/🧵
We've shown before that sucralose alters the human microbiome (tinyurl.com/SuezCell22), and we know that the microbiome can impact responsiveness to cancer immunotherapy.
1+1=...? Yes!
The authors show that sucralose-elicited changes can disrupt immunotherapy efficacy.
2/🧵
1+1=...? Yes!
The authors show that sucralose-elicited changes can disrupt immunotherapy efficacy.
2/🧵
July 31, 2025 at 5:24 PM
We've shown before that sucralose alters the human microbiome (tinyurl.com/SuezCell22), and we know that the microbiome can impact responsiveness to cancer immunotherapy.
1+1=...? Yes!
The authors show that sucralose-elicited changes can disrupt immunotherapy efficacy.
2/🧵
1+1=...? Yes!
The authors show that sucralose-elicited changes can disrupt immunotherapy efficacy.
2/🧵